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| 1 | Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats显示文摘AIM: To investigate the effect of Ginkgo biloba extract on the enteric neurons in the small intestine of diabetic rats. METHODS: Fifteen Wistar rats were divided into three groups: control group (C), diabetic group (D) and diabetic-treated (DT) daily with EGb 761 extract (50 mg/kg body weight) for 120 d. The enteric neurons were identified by the myosin-V immunohistochemical technique. The neuronal density and the cell body area were also analyzed. RESULTS: There was a significant decrease in the neuronal population (myenteric plexus P = 0.0351; submucous plexus P = 0.0217) in both plexuses of the jejunum in group D when compared to group C. With regard to the ileum, there was a significant decrease (P = 0.0117) only in the myenteric plexus. The DT group showed preservation of the neuronal population in the jejunum submucous plexus and in the myenteric plexus in the ileum. The cell body area in group D increased significantly (P = 0.0001) in the myenteric plexus of both segments studied as well as in the ileum submucosal plexus, when compared to C. The treatment reduced (P = 0.0001) the cell body area of the submucosal neurons of both segments and the jejunum myenteric neurons. CONCLUSION: The purified Ginkgo biloba extract has a neuroprotective effect on the jejunum submucous plexus and the myenteric plexus of the ileum of diabetic rats. | Glasiella Gonzalez Perez da Silva Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2011 | World Journal of Gastroenterology2011，17，7： | 8 |
| 2 | Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats显示文摘AIM:To investigate the effect of quercetin supplementation on the myenteric neurons and glia in the cecum of diabetic rats.METHODS:Total preparations of the muscular tunic were prepared from the ceca of twenty-four rats divided into the following groups:control(C),control supplemented with quercetin(200 mg/kg quercetin body weight)(CQ),diabetic(D)and diabetic supplemented with quercetin(DQ).Immunohistochemical double staining technique was performed with HuC/D(general population)/nitric oxide synthase(nNOS),HuC-D/S-100and VIP.Density analysis of the general neuronal population HuC/D-IR,the nNOS-IR(nitrergic subpopulation)and the enteric glial cells(S-100)was performed,and the morphometry and the reduction in varicosity population(VIP-IR)in these populations were analyzed.RESULTS:Diabetes promoted a significant reduction(25%)in the neuronal density of the HuC/D-IR(general population)and the nNOS-IR(nitrergic subpopulation)compared with the C group.Diabetes also significantly increased the areas of neurons,glial cells and VIP-IR varicosities.Supplementation with quercetin in the DQ group prevented neuronal loss in the general population and increased its area(P<0.001)and the area of nitrergic subpopulation(P<0.001),when compared to C group.Quercetin induced a VIP-IR and glial cells areas(P<0.001)in DQ group when compared to C,CQ and D groups.CONCLUSION:In diabetes,quercetin exhibited a neuroprotective effect by maintaining the density of the general neuronal population but did not affect the density of the nNOS subpopulation. | Paulo Emilio Botura Ferreira Cláudia Regina Pinheiro Lopes Angela Maria Pereira Alves der Paulo Belato Alves David Robert Linden Jacqueline Nelisis Zanoni Nilza Cristina Buttow | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 3 | In vivo evaluation of hydro- gels of polyvinyl alcohol with and without carbon nanoparticles for osteochondral repair 显示文摘 | Ana A Nilza A Vanessa P | 2012 | Carbon2012，50，6： | 1 |
| 4 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 5 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 6 | Technology Enhanced Learning in Higher Education: results from the design of a quality evaluation framework显示文摘 | Diogo Casanova António Moreira Nilza Costa | 2011 | Procedia - Social and Behavioral Sciences2011，，： | 1 |
| 7 | Potential of Jamaican banana, coconut eoir and bagasse fibres as composite materials显示文摘 | Nilza G Justiz-Smith G Junior Virgo | 2008 | Material Chatacterization2008，，： | 1 |
| 8 | The potential application of red mud in the production of castings显示文摘 | NILZA J S VERNON E B Gossett O | 2006 | Materials Selene and Engineering2006，420，3： | 1 |
| 9 | NATURAL AND ANTHROPOGENIC FACTORS CONTROLLING GULLY EROSION IN THEBASALTIC UPLAND OF SOUTHERN BRAZIL显示文摘This paper describes an analysis of natural and anthropogenic factors controlling the evolution of gullies in a rural basin in the basaltic upland in the State of Rio Grande do Sul, Southern Brazil. In this region of deep ferrallitic soils with more than 60% clay, runoff and erosion are of increasing concern. In the Tabo?o drainage basin (100 km2), gully erosion was studied in a field survey that measured rills and gullies. Eighty-four gullies were identified. They had an average length of 136 m, were 10 m wide, and 3 m deep and had a volume of 15.458 m3. Each gully was characterised in terms of factors that included slope, geological structure, presence of piping, drainage, soil use, and the presence of surface and subsurface flow. On average, the main channels had knickpoints varying from 2 m to 7 m, and their evolution in the vertical plane increased until bed-rock basalt material was reached, after which gullies increase in width and length. Gully development was also monitored from 1991 to 2003. Subsurface flow appears to be the principal agent controlling their development. Results show that both natural (slope, surface curvature, geological structure and rainfall) and anthropogenic (soil use, road construction) factors are important in gully development. The change in cultural practices throughout the drainage basin from conventional to direct seeding has led to increased subsurface flow, which was more important than surface runoff in causing erosion. However, the higher rainfall during El Ni?o Southern Oscillation (ENSO) events and the consequently higher subsurface flow were the dominant factors. From 1991 to 2003 a total land loss of 1,013 m3 was observed in one gully, with 236 m3 lost during the 1992 ENSO and 702 m3 during the 1997 ENSO; 95% of the total volume lost occurred during ENSO periods. | Ana C. VIERO Nilza M. dos Reis CASTRO Joel A. GOLDENFUM Alfonso RISSO | 2005 | International Journal of Sediment Research2005，20，3： | 0 |
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