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| 1 | Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy 显示文摘 | Niehusmann P Dahnau J Rudlowski C | 2009 | Arch Neurol2009，66，4： | 1 |
| 2 | High-speed all optical switch in ion-implanted silicon-on-insulator or microring resonators显示文摘 | Foerst M Niehusmann J Plotzing T | 2007 | Opt Lett2007，32，14： | 1 |
| 3 | Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi显示文摘 | Pernhorst K Raabe A Niehusmann P | 2011 | J Neuropathol Exp Neurol2011，70，12： | 1 |
| 4 | Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy显示文摘 | Niehusmann P Dalmau J Rudlowski C | 2009 | Arch neurol2009，66，： | 1 |
| 5 | Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy显示文摘 | Niehusmann P Dalmau J Rudlowski C | 2009 | Arch Neurol2009，66，4： | 1 |
| 6 | Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy显示文摘 | Niehusmann P Dalmau J Rudlowski C | 2009 | Arch Neurol2009，66，4： | 1 |
| 7 | Ultrahigh-quality-factor silicon-on-insulator microring resonator显示文摘 | Niehusmann J Vorckel A Bolivar P H | 2004 | Opt Let2004，29，24： | 1 |
| 8 | High- speed all-optical switching in ion-implanted silicon-on-insulator microring resoantors显示文摘 | FORST M NIEHUSMANN J PLOTZING T etal | 2007 | Optic Letters2007，32，14： | 1 |
| 9 | Ultrahigh-qualit y factor silicon-on insulator mieroring resonator显示文摘 | NIEHUSMANN J VORCKEL A BOLIVAR P H | 2004 | Optic Letters2004，29，24： | 1 |
| 10 | Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas显示文摘 | K. Gousias A. Becker M. Simon P. Niehusmann | 2012 | Journal of Neuro-Oncology2012，，3： | 1 |
| 11 | Diagnostic value of Nmethyl-D-aspartate receptor antibodies in women with new-onset epilepsy显示文摘 | Niehusmann P Dalmau J Rudlowski C | 2009 | Arch Neurol2009，66，4： | 1 |
| 12 | Surgical management and long-term seizure outcome after epilepsy surgery for different types of epilepsy associated with cere- bral cavernous malformations 显示文摘 | Brelie CV Malter MP Niehusmann P | 2013 | Epilepsia2013，54，9： | 1 |
| 13 | Surgical management and long-term seizure outcome after epilepsy surgery for different types of epilepsy associated with cerebral cavernous malformations 显示文摘 | yon der Brelie C Malter MP Niehusmann P | 2013 | Epilepsia2013，54，1： | 1 |
| 14 | Coincidence de- tection and stress modulation of spike time-dependent long-term depression in the hippocampus显示文摘 | Niehusmann P Seifert G Clark K | 2010 | J Neurosci2010，30，18： | 1 |
| 15 | A potential role of karyopherin a2 in the impaired maturation of dendritic cells observed in glioblastoma patients显示文摘Aim:Patients with glioblastomas demonstrate well‑documented immunological impairments including decreased numbers of mature dendritic cells(DCs).Recent data identified karyopherin a2(KPNA2),a nucleocytoplasmic shuttling receptor,as diagnostic and prognostic biomarker for gliomas.The aim of this ongoing study is to correlate parameters of immunity and nucleocytoplasmic transport in glioblastoma patients.Methods:We preoperatively collected serum from 17 patients with glioblastomas and determined DC subsets(HLA DR+Lin-,CD34-,CD45+,CD123+,CD11+were analyzed)using a 6‑color flow cytometry panel.Expression levels of KPNA2 and nuclear accumulation of p53 were evaluated semi‑quantitatively by immunohistochemistry.O6‑methylguanine DNA methyltransferase(MGMT)and isocitrate dehydrogenase‑1(IDH‑1)status were assessed by pyrosequencing and immunohistochemistry,respectively.Results:Median expression levels for both KPNA2 and p53 were 5-10%.IDH‑1‑R132H mutation and MGMT promoter hypermethylation was detected in 3/16 and 1/9 patients,respectively.Mean counts of total mature DCs,myeloid DCs and plasmacytoid DCs were 9.6,2.1,3.4 cells/μL.A preliminary analysis suggests an association between low KPNA2 nuclear expression and increased numbers of mature DCs.However,this correlation did not reach statistical significance so far(P=0.077).Conclusion:Our preliminary data may indicate a role of KPNA2 in the impaired maturation of DCs observed in glioblastoma patients. | Konstantinos Gousias Alexander von Ruecker Gerrit H.Gielen Pitt Niehusmann Andreas Waha Hartmut Vatter Matthias Simon | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 0 |
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