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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | A highly modular adaptive lattice algorithm for multi-channel least squares filtering显示文摘 | George O G Nicholas K | 1995 | IEEE Trans Signal Processing1995，46，1： | 1 |
| 4 | A generalized Petri net modeling approach for the control of re-entrant flow semiconductor wafer fabrication显示文摘 | Nicholas G O Jonathan D G Adrienne A | 2001 | Robotics and Computer Integrated Manufacturing2001，17，： | 1 |
| 5 | A generalized Petri net modeling approach for the control of re-entrant flow semiconductor wafer fabrication显示文摘 | Nicholas G O Jonathan D G Adrienne A | 2001 | Robotics and Computer Integrated Manufacturing2001，17，1： | 1 |
| 6 | Effect of temperature of liquid nitrogen on radiation resistance of spores of Clostridium botulinum显示文摘 | NICHOLAS G SNYDER O P WALKER A A | 1965 | Microbiol1965，13，： | 1 |
| 7 | Regional and temporal variation in American Red Cross blood donations, 1995 to 2005 显示文摘 | Stephen O Nicholas G Ming - wen AN et 81 | 2008 | transfusion2008，48，8： | 1 |
| 8 | Type 2 Diabetes Mellitus: The impact on coloreclal adenoma risk in women显示文摘 | Jill EE Feng G Nicholas O | 2006 | Am J Gastroenterol2006，10，1： | 1 |
| 9 | Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells:A novel system for antigen production and phage antibody isolation显示文摘 | Jennings N S Smethurst P A Knight C G O'Connor M N Korhonen L J Stafford P Stephens J Stephen F G Ian J H Richard W F Nicholas A W Willem H O | | 0，，： | 1 |
| 10 | Esomeprazole 40 mg and 20 mg is efficacious in the long-term management of patients with endoscopy-negative gastro-oesophageal reflux disease: a placebo-controlled trial of on-demand therapy for 6 months显示文摘 | Nicholas J. Talley Thomas L. Venables Jonathan R. B. Green David Armstrong Kevin P. J. O’Kane Mustafa Giaffer Karna D. Bardhan Rolf G. S. Carlsson Samuel Chen G?ran S. Hasselgren | 2002 | European Journal of Gastroenterology & Hepatology2002，，8： | 1 |
| 11 | Quantitative imaging biomarkers: A review of statistical methods for technical performance assessment显示文摘 | Raunig David L McShane Lisa M Pennello Gene Gatsonis Constantine Carson Paul L Voyvodic James T Wahl Richard L Kurland Brenda F Schwarz Adam J G?nen Mithat Zahlmann Gudrun Kondratovich Marina V O’Donnell Kevin Petrick Nicholas Cole Patricia | 2015 | Statistical Methods in Medical Research2015，，： | 1 |
| 12 | f- - AR polymor- phisms and glycemic and lipidparameters in hypertensive individuals receiving carvedilol or metoprolol 显示文摘 | Vardeny O Nicholas G Andrei A | 2012 | Am J Hy - pertens2012，25，8： | 1 |
| 13 | Concerted effects of aldosterone and radicals on the expression of plasra in activat or inhibior 1 in the cultured rats' mesangial cells显示文摘 | STEFEN G NICHOLAS O INGEBORG A | 2001 | Intem Med2001，40，7： | 1 |
| 14 | Japanese Purchases,Exchange Rates,and Speculation in Residential Real Estate Markets显示文摘 | Miller N G Michael A S Nicholas O | 1988 | Journal of Real Estate Research1988，，3： | 1 |
| 15 | 13 -AR polymorphisms and glycemic and lipid parameters in hypertensive individuals receiv- ing carvedilol or metoprolol 显示文摘 | Vardeny O Nicholas G Andrei A | 2012 | Am J Hy- pertens2012，25，8： | 1 |
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