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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Field and laboratory studies of Desmodora cazca Gerlach,1956 (Desmodoridae:Nematoda) from mangrove mud-flats显示文摘 | Nicholas W L Stewart A C Marples T G | 1988 | Nematologica1988，34，3： | 1 |
| 3 | Tourism dynamics: Cyprus' hotel value chain and profitability显示文摘 | Nicholas C G | 2003 | System Dynamics Review2003，19，3： | 1 |
| 4 | Plant antitumor agents(29): Synthesis and biological activity of ring D and ring E modified analogues of camptothecin显示文摘 | Nicholas A W Wani M C Manikumar G | 1990 | J Med Chem1990，33，3： | 1 |
| 5 | Ytterbium trifluoromethanesulfonate as a novel catalyst for the allylation of aldehydes 显示文摘 | HELEN C A ANDREW F B NICHOLAS G | 1994 | Tetrahedron Letters1994，35，26： | 1 |
| 6 | A comparison of the stable and student distributions as statistical models for stock prices 显示文摘 | Blattberg R C Nicholas J G | 1974 | Journal of Business1974，47，2： | 1 |
| 7 | A rapid capillary gel electrophoresis method for the quantitative determination of Rubisco in spinach显示文摘 | NICHOLAS K U G FORMEY C F PAULSON A T | 2002 | Phytochemanal2002，13，： | 1 |
| 8 | G protein selectivity determinant specified by a viral chemokine receptor-conserved region in the C tail of the human herpesvirus 8 G protein-coupled receptor 显示文摘 | Liu C Sandford G Guo F and Nicholas J | 2004 | J Virology2004，78，5： | 1 |
| 9 | A policy case study of blood in Australia显示文摘 | Nicholas G Gina C Mary H | 2010 | Social Science & Medicine2010，71，9： | 1 |
| 10 | Methylbenzenes are the organic reaction centers for methanol-to-olefin catalysis on HSAPO-34显示文摘 | SONG W G HAW J F NICHOLAS J B HENEGHAN C S | 2000 | J Am Chem Soc2000，122，10： | 1 |
| 11 | Service quality, relationship satisfaction, trust, commitment and business,to-business loyalty显示文摘 | Ruben C C Nicholas G P | 2007 | European Journal of Marketing2007，41，78： | 1 |
| 12 | Phase I / II trial of custirsen (OGX-Oll) , an inhibitor of clusterin, in eombination with a gemcit- abine and platinum regimen in patients with previously untreated ad- vanced non-small een lung cancer 显示文摘 | Laskin JJ Nicholas G Lee C | 2012 | J Thorac Oncol2012，7，3： | 1 |
| 13 | Roles for cyclopentenyl cations in the synthesis of hydrocarbons from methanol on zeolite catalyst HZSM-5 显示文摘 | HAW J F NICHOLAS J B SONG W G DENG F WANG Z K XU T HENEGHAN C S | 2000 | J Am Chem Soc2000，122，19： | 1 |
| 14 | A clinical nutrition course to improve pharmacy students' skills and confidence in counseling patients显示文摘 | Linda C Nicholas G Popovich C | 2008 | Am J Pharm Educ2008，72，3： | 1 |
| 15 | Seq-Gen: An application for the Monte Carlo simulation of DNA sequence evolution along phylogenetic trees 显示文摘 | Rambaut A Nicholas C G | 1997 | Computer Applications Bioscience1997，13，3： | 1 |
| 16 | IT doesn' t matter显示文摘 | | 2003 | Harvard Business Review2003，，： | 1 |
| 17 | The nature of the chromium species formed during the thermal activa-tion of chromium-promoted tin(IV)oxide catalysts:an EPR and XPS study显示文摘 | Philip G Nicholas C Wayne D | 1998 | J Phys Chem B1998，102，10： | 1 |
| 18 | Effects of stage of lactation and time of year on plasmin-derived activity in bovine milk in New Zealand显示文摘 | NICHOLAS G D AULDIST M J MOLAN P C | 2002 | Journal of Dairy Research2002，69，： | 1 |
| 19 | Phase I/II trial of custirsen (OGX-011 ), an inhibitor of clusterin, in combination with a gemc- itabine and platinum regimen in patients with previously untreated advanced non-small cell lung cancer 显示文摘 | Laskin J J Nicholas G Lee C | 2011 | J Thorac Oncol2011，7，3： | 1 |
| 20 | Methylbenzenes are the organic reaction centers for methanol-to-olefin catalysis on HSAPO-34显示文摘 | SONG W G HAW J F NICHOLAS J B HENEGHAN C S | 2000 | J Am Chem Soc2000，122，10： | 1 |
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