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| 1 | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system显示文摘In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The formulation of the TMP and BN microemulsion(TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher( P < 0.05) C max and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group( P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. | Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 2 | High‐performance ZnO varistor ceramics prepared by arc‐induced flash sintering with low energy consumption at room temperature显示文摘The development of ultra‐high voltage transmission lines requires a ZnO arrester with excellent electrical response and high voltage gradient.Compared with conventional preparation methods,flash sintering allows fast production of novel high‐performance ZnO varistor ceramics with low energy consumption and controlled grain growth.Herein,ZnO varistor ceramics were prepared using the flash sintering method at an air pressure of 21 kPa for 60 s at 25℃.The results showed that the flash‐sintered samples had fine grains and reduced loss of volatile elements.Moreover,the voltage gradient,leakage current density,and non‐linear coefficient of the flash‐sintered varistor ceramics were significantly improved compared with those of conventionally sintered samples.Owing to the short preparation time and absence of a heating process,the energy consumption of the proposed flash sintering method was significantly reduced to 10%of that by conventional sintering.The proposed method is a promising approach for the preparation of ZnO arresters with excellent electrical properties and serves as an effective method that realises energy saving and emission reduction. | Angxuan Wu Zhixiang Zhu Xilin Wang Nianping Yan Hongyang Zhou Rongxia Huang Guoming Ma Zhidong Jia Liming Wang | 2022 | High Voltage2022，7，2： | 2 |
| 3 | Novel polymeric Nanoparticles containing Tanshione I1 s for the treatment of Hepatoma显示文摘 | Qi Li Yan Wang ( co-author) Nianping Feng | 2008 | J Drug Target2008，16，10： | 1 |
| 4 | Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma 显示文摘 | Li Qi Wang Yan Feng Nianping | 2008 | J Drug Target2008，16，10： | 1 |
| 5 | Dielectric barrier discharge-based defect engineering method to assist flash sintering显示文摘Oxygen vacancy OV plays an important role in a flash sintering (FS) process. In defect engineering, the methods of creating oxygen vacancy defects include doping, heating, and etching, and all of them often have complex processes or equipment. In this study, we used dielectric barrier discharge (DBD) as a new defect engineering technology to increase oxygen vacancy concentrations of green billets with different ceramics (ZnO, TiO_(2), and 3 mol% yttria-stabilized zirconia (3YSZ)). With an alternating current (AC) power supply of 10 kHz, low-temperature plasma was generated, and a specimen could be treated in different atmospheres. The effect of the DBD treatment was influenced by atmosphere, treatment time, and voltage amplitude of the power supply. After the DBD treatment, the oxygen vacancy defect concentration in ZnO samples increased significantly, and a resistance test showed that conductivity of the samples increased by 2–3 orders of magnitude. Moreover, the onset electric field (E) of ZnO FS decreased from 5.17 to 0.86 kV/cm at room temperature (RT);while in the whole FS, the max power dissipation decreased from 563.17 to 27.94 W. The defect concentration and conductivity of the green billets for TiO_(2) and 3YSZ were also changed by the DBD, and then the FS process was modified. It is a new technology to treat the green billet of ceramics in very short time, applicable to other ceramics, and beneficial to regulate the FS process. | Xinhao Zhao Nianping Yan Yueji Li Zikui Shen Rongxia Huang Chen Xu Xuetong Zhao Xilin Wang Ruobing Zhang Zhidong Jia | 2023 | Journal of Advanced Ceramics2023，12，5： | 0 |
| 6 | Gas-discharge induced flash sintering of YSZ ceramics at room temperature显示文摘This is the first study to conduct the flash sintering of 3 mol%yttria-stabilized zirconia(3YSZ)ceramics at room temperature(25℃)under a strong electric field,larger than 1 kV/cm.At the standard atmospheric pressure(101 kPa),the probability of successful sintering is approximately half of that at low atmospheric pressure,lower than 80 kPa.The success of the proposed flash sintering process was determined based on the high electric arc performance at different atmospheric pressures ranging from 20 to 100 kPa.The 3YSZ samples achieved a maximum relative density of 99.5%with a grain size of~200 nm.The results showed that as the atmospheric pressure decreases,the onset electric field of flash sintering decreases,corresponding to the empirical formula of the flashover voltage.Moreover,flash sintering was found to be triggered by the surface flashover of ceramic samples,and the electric arc on the sample surfaces floated upward before complete flash sintering at overly high pressures,resulting in the failure of flash sintering.This study reveals a new method for the facile preparation of flash-sintered ceramics at room temperature,which will promote the application of flash sintering in the ceramic industry. | Yuchen ZHU Hongyang ZHOU Rongxia HUANG Nianping YAN Xilin WANG Guanghua LIU Zhidong JIA | 2022 | Journal of Advanced Ceramics2022，11，4： | 0 |
| 7 | A versatile defect engineering strategy for room-temperature flash sintering显示文摘In this study,we reported that flash sintering(FS)could be efficiently triggered at room temperature(25℃)by manipulating the oxygen concentration within ZnO powders via a versatile defect engineering strategy,fully demonstrating a promising method for the repaid prototyping of ceramics.With a low concentration of oxygen defects,FS was only activated at a high onset electric field of~2.7 kV/cm,while arcs appearing on the surfaces of samples.Strikingly,the onset electric field was decreased to<0.51 kV/cm for the activation of FS initiated,which was associated with increased oxygen concentrations coupled with increased electrical conductivity.Thereby,a general room-temperature FS strategy by introducing intrinsic structural defect is suggested for a broad range of ceramics that are prone to form high concentration of point defects. | Angxuan WU Ziyang YAN Xilin WANG Zhiyang YU Rongxia HUANG Nianping YAN Zhidong JIA | 2022 | Journal of Advanced Ceramics2022，11，7： | 0 |
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