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| 1 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 2 | Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection显示文摘 | Teng YT Nguyen H Gao X | 2000 | J Clin Invest2000，106，6： | 2 |
| 3 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 4 | Exact analytical solution for three-dimensional interception of a maneuvering target显示文摘 | Nguyen X | 1998 | The Journal of Astronautical Sciences1998，46，3： | 1 |
| 5 | Tyndallometry with the laser flare cell meter in intraocular in flammation 显示文摘 | Kuchle M Nguyen N X Naumann G O | 1994 | Ophthalmologe1994，91，2： | 1 |
| 6 | Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection显示文摘 | TENG YT NGUYEN H GAO X | 2000 | J Clin Invest2000，106，6： | 1 |
| 7 | Transcription factor PITX3 gene in Parkinson' s disease 显示文摘 | Le W Nguyen D Lin X W | 2011 | Neurobiol Aging2011，32，4： | 1 |
| 8 | VEP test ofthe blue sensitive pathway in glaucoma显示文摘 | Moskowitz A N Korth M Nguyen N X | 1994 | InvestOphthalmol Via Sci1994，35，5： | 1 |
| 9 | Nonlinear diffusive mixing in microchannels:theory and experiments显示文摘 | WU Z NGUYEN N T HUANG X | 2004 | Journal of Micromechanics and Microengineering2004，14，4： | 1 |
| 10 | Quantitative a- nalysis of cellular inflammation after traumatic spinal cord in- jury : evidence for a multiphasic inflammatory response in the acute to chronic environment显示文摘 | Beck K D Nguyen H X Galvan M D | 2010 | Brain2010，133，2： | 1 |
| 11 | Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line显示文摘 | Nguyen H X Nguyen M T T Nguyen T A | 2013 | Fitoterapia2013，91，： | 1 |
| 12 | Adaptive response surface method based on a double weighted regression technique 显示文摘 | Nguyen X S Sellier A Duprat F | 2009 | Probabilistic Engineering Mechanics2009，24，2： | 1 |
| 13 | Mediators of vascular remodelling co-opted for sequential steps in lung metastasis 显示文摘 | Gupta G P Nguyen D X Chiang A C | 2007 | Nature2007，446，7137： | 1 |
| 14 | Aqueous Ethlenedi- amine for CO2 Capture 显示文摘 | Zhou S Chen X Nguyen T | 2010 | ChemSusChem2010，3，： | 1 |
| 15 | Genetic diversity and bottleneck analysis of Yunnan mithun (Bos frontalis) using microsatellite loci显示文摘 | Qu K X Nguyen S N He Z X | 2012 | Afr J Biotechnol2012，11，12： | 1 |
| 16 | Neuraminidase inhibitor sus- ceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir显示文摘 | Wang D Sleeman K Huang W Nguyen H T LevineM Cheng Y Li X Tan M Xing X Xu X Klimov A I Gubareva L V Shu Y | 2013 | Antiviral Research2013，97，3： | 1 |
| 17 | On the strength of the hydrogen carbon Interaction as deduced from physisorption显示文摘 | NGUYEN T X BAE J S WANG Y | 2009 | Langmuir2009，25，8： | 1 |
| 18 | , Relation of Cd4+ CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease 显示文摘 | Ling E M Smith T Nguyen X D | 2004 | Lancet2004，363，9409： | 1 |
| 19 | The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter显示文摘 | Pan X Liu J Nguyen T | 2013 | Nat Cell Biol2013，15，12： | 1 |
| 20 | Polymer membranes for high temperature proton exchange membrane fuel cell: Recent ad- vances and challenges显示文摘 | Bose S Kuila T Nguyen T X H | 2011 | Prog Polym Sci2011，36，6： | 1 |
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