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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 3 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine显示文摘 | O'NEIL M M KENNEDY C A BARTON R W | 2001 | Gene Therapy2001，，8： | 1 |
| 4 | Experimental p-y model for submerged,stiff clay显示文摘 | Dunnavant T W O'Neil M W | 1989 | Journal of the Geotechnical and Engineering1989，115，1： | 1 |
| 5 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 6 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotroph Appl显示文摘 | ROBERTSON L A VAN NEIL E W J TORREMANS R A M | 1988 | Environ Mcrobiol1988，54，11： | 1 |
| 7 | Retardation of photo-yellowing of lignin-rich pulp显示文摘 | NEIL A W BRAD M | | Polymer Degradation and Stability0，69，1： | 1 |
| 8 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 9 | Association of glycaemia with macrovasular and microvasular complications of type 2 diabetes prospective observational study 显示文摘 | IRENE M Stratton Amanda I Adler H Andrew W Neil | 2000 | BMJ2000，321，8： | 1 |
| 10 | Chicken interferona types I and II enhance synergistically the antiviral state and nitric oxide secretion显示文摘 | Sekellick M J Lowenthal J W 0 Neil T E | 1998 | Interferon Cytokine Res1998，18，： | 1 |
| 11 | Simultaneous Nitrification and Denitrification in Aerobic Chemostat Cultures Cultures of Thiosphaera Pantotroph显示文摘 | ROBERTSON L A VAN NEIL E W J TORREMANS R A M | 1988 | Appl Environ Mcrobiol1988，54，11： | 1 |
| 12 | Virus-Like Particles Associated with Lyngbya majuscula (Cyanophyta;Oscillatoriacea) Bloom Decline in Moreton Bay,Australia显示文摘 | Hewson I O'Neil J M Dennison W C | 2001 | Aquatic Microbial Ecology2001，25，： | 1 |
| 13 | Transferable dis charge permits and economic efficiency: The Fox River显示文摘 | O'NEIL W DAVID M MOORE C | 1983 | Journal of Environmental Economics and Management1983，10，4： | 1 |
| 14 | Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial显示文摘 | Hagop M Kantarjian Andreas Hochhaus Giuseppe Saglio Carmino De Souza Ian W Flinn Leif Stenke Yeow-Tee Goh Gianantonio Rosti Hirohisa Nakamae Neil J Gallagher Albert Hoenekopp Rick E Blakesley Richard A Larson Timothy P Hughes | 2011 | Lancet Oncology2011，，9： | 1 |
| 15 | Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class a β-1actamase, KPC-3, in a New York medical center 显示文摘 | Neil W Philip M Tierno JR | 2004 | Antimicrob Agent Chemother2004，48，12： | 1 |
| 16 | The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change显示文摘 | O'Neil J M Davis T W Burford M A | 2012 | Harmful Algae2012，14，： | 1 |
| 17 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 18 | Dopamine and serotonin receptor binding and antipsychotic efficacy显示文摘 | Neil M R Jeffrey A W Aaron D L | 2007 | Neuropsy chopharmacology2007，32，： | 1 |
| 19 | Coadministration of IFN-γenhances antibody re- sponses in chickens 显示文摘 | LWENTHAL J W O NEIL T E BROADWAY M | 1998 | Journal Interferon and Cyto- kine Research1998，18，8： | 1 |
| 20 | The rise of harmful cyanobacteria blooms : the potential roles of eutrophica- tion and climate change显示文摘 | O'NEIL J M DAVIS T W BURFORD M A | 2012 | Harmful algae2012，，14： | 1 |
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