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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine显示文摘 | O'NEIL M M KENNEDY C A BARTON R W | 2001 | Gene Therapy2001，，8： | 1 |
| 3 | Reinforcement and accessories overview 显示文摘 | NICK C NEIL W | 2001 | Concrete2001，35，3： | 1 |
| 4 | Plastic-film mulch in Chinese agriculture:Importance and problems显示文摘 | Yan C R He W Q Neil C | 2014 | World Agriculture2014，4，2： | 1 |
| 5 | Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS:23)显示文摘 | Turner R C Millns H Neil H A W | 1998 | BMJ1998，318，： | 1 |
| 6 | Nitric oxide prevents leukocxyte adherence role of superoxide显示文摘 | Gaboury J Richard C W Neil G | 1993 | Am J Physiol1993，265，： | 1 |
| 7 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 8 | Virus-Like Particles Associated with Lyngbya majuscula (Cyanophyta;Oscillatoriacea) Bloom Decline in Moreton Bay,Australia显示文摘 | Hewson I O'Neil J M Dennison W C | 2001 | Aquatic Microbial Ecology2001，25，： | 1 |
| 9 | Transferable dis charge permits and economic efficiency: The Fox River显示文摘 | O'NEIL W DAVID M MOORE C | 1983 | Journal of Environmental Economics and Management1983，10，4： | 1 |
| 10 | Metal distribution and spectro- scopic analysis after soil washing with chelating agents and hu- mic substances显示文摘 | Daniel C W Tsang Neil R | 2014 | Environ Sci Pollut Res2014，，21： | 1 |
| 11 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 12 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine 显示文摘 | O'NEIL MM KENNEDY C A BARTON R W | 2001 | Gene Ther2001，8，： | 1 |
| 13 | Transgenic embryos and mice produced from low titre lentiviral vectors显示文摘 | Rirchie W A Neil C King T | 2007 | Transgenic Res2007，16，5： | 1 |
| 14 | On the application of the microgenetic algorithm to the design of broad - band microwave absorbers comprising frequency - selective surfaces embedded in multilayered dielectric media 显示文摘 | Sourav C Raj M Neil R W | 2001 | IEEE Transactions on Microwave Theory and Techniques2001，49，6： | 1 |
| 15 | Environmental biotechnology towards sustainability 显示文摘 | Lawrence P W Neil C B | 2000 | Curr Opin Biotechnol2000，11，3： | 1 |
| 16 | The science of timekeeping 显示文摘 | Allan D W Neil Ashby and Clifford C Hodge | 2001 | Agilent Technologies2001，37，64： | 1 |
| 17 | Employees that think and act like owners : effects of ownership beliefs and behaviors on organizational effectiveness 显示文摘 | STEPHEN H W CHRISTOPHER P P NEIL D C | 2003 | Personnel Psy- chology2003，，56： | 1 |
| 18 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 19 | Corrosion of magnesium alloy ZE41 - The role of mierostructural features 显示文摘 | Neil W C Forsyth M Howlett P C | 2009 | Corrosion Science2009，51，2： | 1 |
| 20 | Corrosion of heat treated magnesium alloy ZE41 显示文摘 | Neil W C Forsyth M Howlett P C | 2011 | Corrosion Science2011，53，10： | 1 |
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