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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | The impact of electronic word-of-mouth显示文摘 | Cheung Christy M K Lee Matthew K O Rabjohn Neil | 2008 | Internet Research2008，，3： | 3 |
| 3 | Role of coronary physiology in the contemporary management of coronary artery disease显示文摘Coronary artery disease(CAD) remains the leading cause of death worldwide with approximately 1 in 30 patients with stable CAD experiencing death or acute myocardial infarction each year. The presence and extent of resultant myocardial ischaemia has been shown to confer an increased risk of adverse outcomes. Whilst, optimal medical therapy(OMT) forms the cornerstone of the management of patients with stable CAD, a significant number of patients present with ischaemia refractory to OMT. Historically coronary angiography alone has been used to determine coronary lesion severity in both stable and acute settings. It is increasingly clear that this approach fails to accurately identify the haemodynamic significance of lesions; especially those that are visually 'intermediate' in severity. Revascularisation based upon angiographic appearances alone may not reduce coronary events above OMT. Technological advances have enabled the measurement of physiological indices including the fractional flow reserve, the index of microcirculatory resistance and the coronary flow reserve. The integration of these parameters into the routine management of patients presenting to the cardiac catheterization laboratory with CAD represents a critical adjunctive tool in the optimal management of these patients by identifying patients that would most benefit from revascularisation and importantly also highlighting patients that would not gain benefit and therefore reducing the likelihood of adverse outcomes associated with coronary revascularisation. Furthermore, these techniques are applicable to a broad range of patients including those with left main stem disease, proximal coronary disease, diabetes mellitus, previous percutaneous coronary intervention and with previous coronary artery bypass grafting. This review will discuss current concepts relevant to coronary physiology assessment, its role in the management of both stable and acute patients and future applications. | Neil Ruparelia Rajesh K Kharbanda | 2015 | World Journal of Clinical Cases2015，3，2： | 2 |
| 4 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 5 | Effects of urbanization on plant flowering phenology: A review 显示文摘 | Neil K Wu J G | 2006 | Urban Ecosyst2006，9，3： | 1 |
| 6 | Oxygen isotope fractionation divalent metal carbonates显示文摘 | O'Neil J R Clayton R N Mayada T K | 1969 | Chemistry Geophysics1969，51，： | 1 |
| 7 | The value of the world’s ecosystemservices and natural capita1显示文摘 | Costanza R Arge R Groot R Farberk S Grasso M HannonB Limburg K Naeem S O’Neil R Paruelo J Raskin R Suttonkk P &Belt M | 1997 | Nature1997，387，： | 1 |
| 8 | Performance of Precast/Prestressed Concrete Building Structures during Northridge Earthquake 显示文摘 | lverson James k Neil M Hawkins | 1994 | PCI Jouranal1994，，2： | 1 |
| 9 | A cross- national comparison and taxonomy of DEA-based hospital efficiency studies显示文摘 | O'Neil L Rauner M Hedidenberger K | 2008 | Soc Econ Plan Sci2008，42，3： | 1 |
| 10 | Structural basis of a phololropinlight switch显示文摘 | Harper S M Neil L C Gardner K H | 2003 | Science2003，301，5639： | 1 |
| 11 | The RUNX genes:gain or loss of function in cancer 显示文摘 | Blyth K Cameron ER Neil JC | 2005 | Nat Rev Cancer2005，5，5： | 1 |
| 12 | How calmodulin binds its targets: sequence independent recognition of amphiphilic a-helices 显示文摘 | O' Neil K T DeGrado W F | 1990 | Trends Biochem Sci1990，15，2： | 1 |
| 13 | Quantitative ex-pression of osteopontin in nasal mucosa of patients with allergic rhi-nitis :effects of pollen exposure and nasal glucocorticoid treatment显示文摘 | O’NEIL S E MALMHALL C SAMITAS K | 2010 | Allergy Asthma and Clinical Immunology2010，6，1： | 1 |
| 14 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972，77，： | 1 |
| 15 | Effects of urbanization on plant flowering phenolo-gy:A review显示文摘 | Neil K Wu J | 2006 | Urban Ecosystems2006，9，： | 1 |
| 16 | How does modifying a DEM to reflect known Hydrology affect subsequent terrain analysis显示文摘 | Callow J N Van Neil K P Boggs G S | 2007 | Journal of Hydrology2007，，： | 1 |
| 17 | Oxygen isotope exchange between quartz and water 显示文摘 | Clayton R N O'Neil J R Mayeda T K | 1972 | Journal of Geophysical Research1972，77，： | 1 |
| 18 | Dissociation of oceanic methane hydrate as a cause of the carbon isotope ezcursion at the end of the Paleocene显示文摘 | Dickens G R O'Neil J R Rea D K | 1995 | Paleoceanography1995，10，： | 1 |
| 19 | Application of stable isotopes to identify problems in large-scale water transfer in Grand Canyon National Park显示文摘 | Neil L Ingraham Kim Zukosky David K Kreamer | 2001 | Environmental Science & Technology2001，35，4： | 1 |
| 20 | Understanding the Char- acteristics of Quality for Software Engineering Processes : A Grounded Theory Investigation 显示文摘 | TRENT A K NEIL J D STEPHEN C C | 2014 | Information and Software Technology2014，56，2： | 1 |
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