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32篇 您的检索式:作者名="Neerven"
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1Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook 2019Regenerative Biomaterials2019,6,2:4
2查看详情显示文摘Van Neerven RJJ 0,,:1
3Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression显示文摘Van Neerven RJ Van de Pol MM Van der Zee JS 1998Clin Exp Allergy1998,28,4:1
4The role of allergen-specific T cells in the allergic immune response: relevance to allergy vaccination 显示文摘 1999Allergy1999,54,6:1
5Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression 显示文摘Van Neerven RJ Van de Pol MM Van der Zee JS 1998Clin Exp Allergy1998,28,:1
6Requirement of CD28-CD86 costimulation for allergen specific T cell proliferation and cytokine expression显示文摘VAN NEERVEN R J VANDEPOL M M VAN DERZEE J S 1998Clin Exp Allergy1998,28,:1
7Preserved epitope-specitlc T cell activation by recombinant Bet v 1-MBP fusion proteins显示文摘Neerven R J Sparholt S H Schou C 1998Clin Exp Allergy1998,28,4:1
8Systemic but not local administration of retinoic acid reduces early transcript levels of pro- inflammatory eytokines after experimental spinal cord injury 显示文摘Van Neerven S Mey J Joosten EA 2010Neurosei Lett2010,485,:1
9Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression显示文摘Van Neerven RJ Van de Pol MM Van der Zee JS 1998Clin Exp Allergy1998,28,:1
10Exponential Stability of Operators and Semigroups 显示文摘Neerven J M A M 1995J Funct Anal1995,130,2:1
11Blocking antibodies induced by specific allergy vaccination prevent theactivation of CD41 T cells by inhibiting serum-IgE-facilitated allergen presentation显示文摘van Neerven RJ Wikborg T Lund G 1999J Immunol1999,163,:1
12IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy显示文摘van Neerven RJ Knol EF Ejrnaes A 2006Int Arch Allergy Immunol2006,141,:1
13Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression显示文摘 Van de Pol M M Van der Zee J S 1998Clin Exp Allergy1998,28,7:1
14Carotid artery stenting and cardiac surgery in symptomatic patients显示文摘Van Der Heyden J Van Neerven D Sonker U 0,,11:1
15The adjoint of a semigroup of linear operators显示文摘Neerven J V 1992Lecture Notes Math Berlin: Spinger- Verlag1992,1529,:1
16Preserved epitope-specitlc T cell activation by recombinant Bet v 1-MBP fusion proteins显示文摘Neerven R J Sparholt S H Schou C 1998Clin ExpAllergy1998,28,4:1
17Pre-differentiation of mesenchymal stmmal cells in combination with a microslruc- tured nerve guide supports peripheral nerve regeneration in the rat sciatic nerve model显示文摘Boecker AH van Neerven SG Scheffel J 2016Eur J Neurosci2016,43,3:1
18Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4^+ T cell by inhibiting serum-IgE-facilitated allergen presentation显示文摘Van Neerven RJ Wikborg T Lurid G 1999J Immunol1999,163,5:1
19A double-blind,placebocontrolled birch allergy vaccination study:inhibition of CD23-mediated serumimmunoglobulin E-facilitated allergen presentation显示文摘van Neerven RJJ Arvidsson M Ipsen H 2004Clin Exp Allergy2004,34,3:1
20Inflammatory chemokinerelease of astroeytes in vitro is reduced by all-trans retinoic acid显示文摘van Neerven S Regen T Wolf D 2010J Neureehem2010,114,5:1
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