|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Association of Prothrombin (A20210G) and Factor V Leiden (AS06G)with Recurrent Pregnancy Loss显示文摘 | Mieria D Szmal C Neagos D | 2012 | Maedica2012，7，3： | 1 |
| 3 | Vascular endothelial growth factor(VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and-2 heterodimer 显示文摘 | Neagoe PF Lemieux C Sirois MG | 2005 | Biol Chem2005，280，11： | 1 |
| 4 | Titin isoform switch in ischemic human heart disease显示文摘 | Neagoe C Kulke M del Monte F | 2002 | Circulation2002，106，： | 1 |
| 5 | Alcohol affects the skeletal muscle proteins,titin and nebulin in male and female rats显示文摘 | Hunter RJ Neagoe C Jarvelainen HA | 2003 | J Nutr2003，133，4： | 1 |
| 6 | 显示文摘 | Neagoe C Kulke M del Monte F | 2002 | Circulation2002，106，： | 1 |
| 7 | Effects of zearalenone on oxidative stress and inflam-mation in weanling piglets 显示文摘 | MARIN D E PISTOL G C NEAGOE L V | 2013 | Food and ChemicalToxicology2013，58，： | 1 |
| 8 | Titin isoform switch in ischemic human heart disease显示文摘 | Kulke M del Monte F | 2002 | Circulation2002，106，： | 1 |
| 9 | The clinical implica- tions of platelet derived growth factor B,vascular endothelial growth factor and basic fibroblast growth factor in colorectal cancer 显示文摘 | Ionescu C Berindan - Neagoe I Burz C | 2011 | J BUON2011，16，2： | 1 |
| 10 | Apoptosis in cancer: key molecular signaling pathways and therapy targets显示文摘 | Burz C Befindan Neagoe I Balacescu O | 2009 | Acta Oncol2009，48，6： | 1 |
| 11 | Effects of zearalenone on oxidative stress and inflammation in weanling piglets显示文摘 | Marin D E Pistol G C Neagoe I V | 2013 | Food and Chemical Toxicology2013，58，： | 1 |
| 12 | Effects of zearalenone on oxidative stress and inflammation in weanling piglets显示文摘 | Marin D E Pistol G C Neagoe I V | 2013 | Food and Chemical Toxicology2013，58，： | 1 |
| 13 | Association of Prothrombin (A20210G) and Factor V Leiden(A506G) with Recurrent Pregnancy Loss显示文摘 | Mierla D Szmal C Neagos D | | 0，，： | 1 |
| 14 | Alcohol affects the skeletal muscle proteins,titin and nebulin in male and female rats显示文摘 | HUNTER R J NEAGOE C N JARVELAINEN H A | 2003 | The Journal of Nutrition2003，133，： | 1 |
| 15 | Alcohol affects the skeletal muscle proteins, titin and nebulin in male and female rats显示文摘 | HUNIER R J NEAGOE C N JARVELAINEN H A | 2003 | The Journal ofNutrition2003，133，： | 1 |
| 16 | Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer显示文摘 | Neagoe PF Lemieux C Sirois MG | 2005 | Biol Chem2005，280，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员