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32篇 您的检索式：作者名="Nazli A"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Enterocyte cytoskeleton changes are crucial for enhanced translocation of nonpathogenic escherichia coli across metabolically stressed gut epithelia显示文摘	Nazli A Wang A Steen O	2006	Infect Immune2006，74，1：	1
3	Epithelia under metabolic stress perceive commensal bacteria as a threat显示文摘	NAZLI A YANG Pingchang JURY J	2004	The American Journal of Pathology2004，164，3：	1
4	A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis显示文摘	Kim CJ Nazli A Rojas OL	2012	Mucosal Immunol2012，5，6：	1
5	A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis显示文摘	Kim CJ Nazli A Rojas OL	2012	Mucosal Immunol2012，5，6：	1
6	A role for mucosal IL-22 pro- duction and Th22 cells in HIV-associated mucosal immunopatho- genesis显示文摘	Kim CJ Nazli A Rojas OL etal	2012	Mucosal Immunol2012，5，6：	1
7	Outbreak caused by NDM-1and RmtB-producing Escherichia coli in Bulgaria显示文摘	Poirel L Savov E Nazli A	2014	Antimicrob Agents Chemother2014，58，4：	1
8	Detection of presence of cow's milk in sheep's cheeses by immunochromatography显示文摘	COLAK H AYDIN A NAZLI B	2006	Food Control2006，17，：	1
9	Effect of flagella on initial attachment of Listeria monocytogenes to stainless steel 显示文摘	Vatanyoopaisarn S Nazli A Dodd C E	2000	Applied and Environmental Microbiology2000，66，2：	1
10	HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium 显示文摘	Nazli A Kafka J K Ferreira V H	2013	J Immnnol2013，191，8：	1
11	Epithelia under metabolic stress perceive commensal bacteria as a threat显示文摘	Nazli A Yang PC Jury J	2004	Am J Pathol2004，164，3：	1
12	A role for mucosal IL22 production and Th22 cells in HIV-associated mucosal immunopathogenesis显示文摘	Kim CJ Nazli A Rojas OL	2012	Mucosal Immunol2012，5，6：	1
13	HIV-1 gpl20 induces TLR2- and TLR4- mediated innate immune activation in human female genital epithelium显示文摘	Nazli A Kafka J K Ferreira V H Anipindi V Muel- ler K Osborne B J Dizzell S Chauvin S Mian M F Ouellet M Tremblay M J Mossman K L Ashkar A A Kovacs C Bowdish D M Snider D P Kaul R Kaushic C	2013	J Immunol2013，191，8：	1
14	Ownership structure and corporate social responsibility disclosure:Some Malaysian evidence显示文摘	Nazli A Mohd Ghazali	2007	Corporate Governance2007，，3：	1
15	Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects显示文摘	Yavuz B B Yavuz B Sener Dede D Cankurtaran M Halil M Ulger Z Nazli N Kabakci G Aytemir K Tokgozoglu L Oto A Ariogul S	2008	Gerontology2008，，3：	1
16	Predictors of exercise induced myocardial ischemia in patients with isolated coronary artery ectasia显示文摘	Altinbas A Nazli C Kinay O	2004	Int J Cardiovasc Imaging2004，20，1：	1
17	Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function andblocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability显示文摘	Howe K L Reardon C Wang A Nazli A McKay D M		0，，：	1
18	A rare cause of acute abdominal pain in adolescence : Hydrosalpinx leading to isolated torsion of fallo- pian tube显示文摘	Pampal A Atac GK Nazli ZS	2012	Journal of Pediatric Surgery2012，47，：	1
19	The diagnostic importance of CEA and CA19-9 for the early diagnosis of pancreatic carcinoma显示文摘	Nazli O Bozdag A D Tansug T	2000	Hepatogastro-enterology2000，47，36：	1
20	Comparison of Gleason scores from sextant prostate biopsies and pastatectomy Specimens显示文摘	Altay B Kefi A Nazli O	2001	Urol Int2001，67，1：	1

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