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| 1 | New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases显示文摘Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia. | Naoki Adachi Tadahiro Numakawa Misty Richards Shingo Nakajima Hiroshi Kunugi | 2014 | World Journal of Biological Chemistry2014，5，4： | 30 |
| 2 | Functional interactions between steroid hormones and neurotrophin BDNF显示文摘Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase pathways.Notably,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson's disease,Alzheimer's disease,and mental disorders.On the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of depression.Interestingly,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic plasticity.Furthermore,it is well known that estrogen plays a role in the pathophysiology of Parkinson's disease,Alzheimer's disease,and mental illness,while serving to regulate BDNF expression and/or function.Here,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen). | Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 3 | Impact of glucocorticoid on neurogenesis显示文摘Neurogenesis is currently an area of great interest in neuroscience.It is closely linked to brain diseases,including mental disorders and neurodevelopmental disease.Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors.Moreover,proliferation/differentiation of the neural stem/progenitor cells(NSPCs)is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase(PI3K)/Akt,hedgehog,and Wnt.Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms;this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases. | Haruki Odaka Naoki Adachi Tadahiro Numakawa | 2017 | Neural Regeneration Research2017，12，7： | 4 |
| 4 | Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis显示文摘AIM: To evaluate the effect of oral intake of branchedchain amino acids (BCAA) on brain perfusion in patients with liver cirrhosis.METHODS: Single photon emission computed tomography scans were performed in 43 patients with cirrhosis and in 15 age-matched healthy subjects.Twenty-nine out of forty-three patients were randomly treated with either BCAA granules or placebo, and single photon emission computed tomography was performed before and after the treatment. We measured the regional cerebral blood flow values using a threedimensional stereotaxic region of interest template.RESULTS: Cirrhotic patients had regions of significant hypoperfusion in the bilateral central (right P=0.039,P<0.05; left P = 0.006 P<0.01), parietal (right P=0.018, P<0.05;left P=0.009, P<0.01), angular (right P=0.039, P<0.05;left P = 0.008, P<0.01), and left pericallosal segments (P= 0.038 P<0.05) as compared with healthy subjects. A significant increase in cerebral perfusion was observed 70 min after the oral intake of BCAA in the angular (right P=0.012,P<0.05;left P=0.049, P<0.05), temporal (right P=0.012, P<0.05; left P=0.038, P<0.05), pericallosal segments (right P = 0.025,P<0.05; left P = 0.049, P<0.05) and left precentral (P=0.044, P<0.05), parietal (P=0.040, P<0.05) and thalamus (P=0.033, P<0.05). No significant change in perfusion was observed in the placebo group.CONCLUSION: Administration of BCAA rapidly improves cerebral perfusion. | Mika Yamamoto Motoh Iwasa Kaname Matsumura Yuri Nakagawa Naoki Fujita Yoshinao Kobayashi Masahiko Kaito Kan Takeda Yukihiko Adachi | 2005 | World Journal of Gastroenterology2005，11，43： | 1 |
| 5 | Variability in Measuring the Ki-67 Labeling Index in Patients With Breast Cancer显示文摘 | Shinya Yamamoto Takashi Chishima Yuka Mastubara Shouko Adachi Fumi Harada Youko Toda Hitoshi Arioka Naoki Hasegawa Yukio Kakuta Kentaro Sakamaki | 2014 | Clinical Breast Cancer2014，，： | 1 |
| 6 | Hepatitis C virus core particle detected by immunoelectron microscopy and optical rotation technique显示文摘 | Satoshi Ishida Masahiko Kaito Michinori Kohara Kyoko Tsukiyama-Kohora Naoki Fujita Jiro Ikoma Yukihiko Adachi Shozo Watanabe | 2001 | Hepatology Research2001，，3： | 1 |
| 7 | Small Cell Carcinoma of the Esophagus with Reference to Alternating Multiagent Chemotherapy: Report of Two Cases显示文摘 | Naohiko Koide Manabu Hiraguri Kyou Kishimoto Toshiyuki Nakamura Wataru Adachi Hideharu Miyabayashi Naoki Terai Jun Amano | 2003 | Surgery Today2003，，4： | 1 |
| 8 | Successful Treatment of a Patient With Severe Calcific Uremic Arteriolopathy (Calciphylaxis) by Etidronate Disodium显示文摘 | Naoki Shiraishi Kenichiro Kitamura Taku Miyoshi Masataka Adachi Yukimasa Kohda Hiroshi Nonoguchi Shuuko Misumi Yoshihiro Maekawa Toshihiko Murayama Masao Tomita Kimio Tomita | 2006 | American Journal of Kidney Diseases2006，，1： | 1 |
| 9 | Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile显示文摘 | Tetsuya Adachi Yasushi Okuno Shigeo Takenaka Kazuyuki Matsuda Naoki Ohta Kyoka Takashima Koji Yamazaki Daisuke Nishimura Kazutaka Miyatake Chisato Mori Gozoh Tsujimoto | 2004 | Food and Chemical Toxicology2004，，4： | 1 |
| 10 | INHIBITION OF NITRIC OXIDE SYNTHESIS AGGRAVATES MYOCARDIAL ISCHEMIA IN HEMORRHAGIC SHOCK IN CONSTANT PRESSURE MODEL显示文摘 | Takeshi Adachi Shingo Hori Koji Miyazaki Masahiro Nakagawa Soshin Inoue Yozo Ohnishi Hiroe Nakazawa Naoki Aikawa Satoshi Ogawa | 1998 | Shock1998，，3： | 1 |
| 11 | Transcriptional Control and Protein Specialization Have Roles in the Functional Diversification of Two Dicer-Like Proteins in Magnaporthe oryzae显示文摘 | Naoki Kadotani Toshiki Murata Nguyen Bao Quoc Yusuke Adachi and Hitoshi Nakayashiki | | 0，，： | 1 |
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