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| 1 | Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review显示文摘Acute respiratory distress syndrome(ARDS) is a syndrome with heterogeneous underlying pathological processes. It represents a common clinical problem in intensive care unit patients and it is characterized by high mortality. The mainstay of treatment for ARDS is lung protective ventilation with low tidal volumes and positive end-expiratory pressure sufficient for alveolar recruitment. Prone positioning is a supplementary strategy available in managing patients with ARDS. It was first described 40 years ago and it proves to be in alignment with two major ARDS pathophysiological lung models; the 'sponge lung'- and the 'shape matching'-model. Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics as it redistributes transpulmonary pressure, stress and strain throughout the lung and unloads the right ventricle. The factors that individually influence the time course of alveolar recruitment and the improvement in oxygenation during prone positioning have not been well characterized. Although patients' response to prone positioning is quite variable and hard to predict, large randomized trials and recent meta-analyses show that prone position in conjunction with a lung-protective strategy, when performed early and in sufficient duration, may improve survival in patients with ARDS. This pathophysiology-based review and recent clinical evidence strongly support the use of prone positioning in the early management of severe ARDS systematically and not as a rescue maneuver or a last-ditch effort. | Vasilios Koulouras Georgios Papathanakos Athanasios Papathanasiou Georgios Nakos | 2016 | World Journal of Critical Care Medicine2016，5，2： | 39 |
| 2 | Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells显示文摘AIM:To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha(TNF-α)-induced gene expression in human gastric adenocarcinoma cells.METHODS:Knockdown experiments were conducted with claudin 1 small interfering RNA(si RNA),and theeffects on the cell cycle,apoptosis,migration and invasion were analyzed in human gastric adenocarcinoma MKN28 cells.The gene expression profiles of cells were analyzed by microarray and bioinformatics.RESULTS:The knockdown of claudin 1 significantly inhibited cell proliferation,migration and invasion,and increased apoptosis.Microarray analysis identified 245genes whose expression levels were altered by the knockdown of claudin 1.Pathway analysis showed that the top-ranked molecular and cellular function was the cellular movement related pathway,which involved MMP7,TNF-SF10,TGFBR1,and CCL2.Furthermore,TNFand nuclear frctor-κB were the top-ranked upstream regulators related to claudin 1.TNF-αtreatment increased claudin 1 expression and cell migration in MKN28 cells.Microarray analysis indicated that the depletion of claudin1 inhibited 80%of the TNF-α-induced m RNA expression changes.Further,TNF-αdid not enhance cell migration in the claudin 1 si RNA transfected cells.CONCLUSION:These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene expression and migration in gastric cancer cells.A deeper understanding of these cellular processes may be helpful in establishing new therapeutic strategies for gastric cancer. | Atsushi Shiozaki Hiroki Shimizu Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Daisuke Iitaka Shingo Nakashima Yoshito Nako Mingyao Liu Eigo Otsuji | 2014 | World Journal of Gastroenterology2014，20，47： | 6 |
| 3 | Rectal neuroendocrine tumor with uncommon metastatic spread:A case report and review of literature显示文摘Neuroendocrine tumors of the gastrointestinal tract are rare neoplasms. Rectal neuroendocrine tumors consist approximately the 5%-14% of all neuroendocrine neoplasms in Europe. These tumors are diagnosed in relatively young patients,with a mean age at diagnosis of 56 years. Distant metastases from rectal neuroendocrine tumors are not very common. Herein we describe a case of a rectal neuroendocrine tumor which metastasized to the lung,mediastinum and orbit. This case underscores the importance of early identification and optimal management to improve patient's prognosis. Therefore,the clinical significance of this case is the necessity of physicians' awareness and education regarding neuroendocrine tumors' diagnosis and management. | Nikolaos Tsoukalas Michail Galanopoulos Maria Tolia Maria Kiakou Georgios Nakos Aristoula Papakostidi Georgios Koumakis | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 3 |
| 4 | Focal fatty liver sparing lesion presenting as a 'pseudotumour':case report显示文摘 | Zezos P Tatsi P Nakos A | 2006 | Acta Gastroenterol Belg2006，69，3： | 1 |
| 5 | Possibility of classification in some species of Lilium by PCR-RFLP of ribulose-1,5-bisphosphate carboxylase large subunit (rbeL) gene and ribosomal RNA gene 显示文摘 | HARUKI K HOSOKI T NAKO Y | 1997 | J Japan Soc Hort Sci1997，66，： | 1 |
| 6 | The local component of the acute cardiovascular response to simulated apneas in brain-dead humans 显示文摘 | Lahana A Costantopoulos S Nakos G | 2005 | Chest2005，128，： | 1 |
| 7 | International alliance commitment and performance of small and medium - size enterprises : The media- ting role of process control 显示文摘 | NAKOS G BROUTHERS K D | 2008 | Journal of International Manage- ment2008，14，2： | 1 |
| 8 | CO2 -ECBM field tests in the Ishikari Coal Basin of Japan显示文摘 | Masaji Fujioka Shinji Yamaguchi Masao Nako | 2010 | International Journal of Coal Geology2010，82，34： | 1 |
| 9 | Relationship between concentration of serum leptin and fetal growth显示文摘 | Harigaya A Nagashima K Nako Y | 1997 | Clin Endocinol Metab1997，82，： | 1 |
| 10 | CO2-ECBM field tests in the Ishikari Coal Basin of Japan显示文摘 | Fujioka M Yamaguchi S Nako M | 2010 | International Journal of Coal Geology2010，82，34： | 1 |
| 11 | Identification of Smad7, a TGF β-inducible antagonist of TGF-β signalling显示文摘 | Nako A Afrakhte M Moren A | 1997 | Nature1997，389，： | 1 |
| 12 | The local component of the acute cardiovascular response to simulated apneas in brain-dead humans 显示文摘 | Lahana A Costantopoulos S Nakos G | 2005 | Chest2005，128，2： | 1 |
| 13 | Influence of non-solublecontaminants on the flashover voltages of artificially contami-nated insulators显示文摘 | Matsuoka R Kondo K Nako K | 1996 | IEEE Transactions on Power Delivery1996，11，1： | 1 |
| 14 | Tripolin A, a novel small-molecule inhibitor of aurora A kinase, reveals new regula- tion of HURP's distribution on microtubules 显示文摘 | Kesisova IA Nakos KC Tsolou A | 2013 | PLoS One2013，8，58： | 1 |
| 15 | Angiotensin ]I Typel receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy 显示文摘 | Ogawa S Moil T Nako T | 2006 | Hypertension2006，47，4： | 1 |
| 16 | Malignant esophageal dysphagia palliation using inser tion of a covered Ultraflex stent without fluoroscopy:a prospective observational study 显示文摘 | LAZARAKI G KATSINELOS P NAKOS A | 2011 | Surg Endosc2011，25，2： | 1 |
| 17 | Evalu- ation of endoscopic mucosal resection for laterally spreading rectal tumors 显示文摘 | TAMURA S NAKO K YOKOYAMA Y | 2004 | Endoscopy2004，36，： | 1 |
| 18 | Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes显示文摘 | Ogawa S Ishiki M Nako K | 2010 | Tobeku J Exp Med2010，223，： | 1 |
| 19 | Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice显示文摘 | Yi-Fei Dong Lei Liu Zhong-Fang Lai Eiichiro Yamamoto Keiichiro Kataoka Taishi Nakamura Masaya Fukuda Yoshiko Tokutomi Hisato Nako Hisao Ogawa Shokei Kim-Mitsuyama | 2010 | Journal of Hypertension2010，，7： | 1 |
| 20 | Effect of the prone position on patients with hydrostatic pulmonary edema compared with patients with acute respiratory dis- tress syndrome and puhnonary fibrosis显示文摘 | Nakos G Tsangaris I Kostanti E | 2000 | Am J Respir Crit Care Med2000，161，2： | 1 |
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