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| 1 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 2 | Ge- netic and physical maps and a clone bank of mitochondri- al DNA from rice 显示文摘 | IWAHASHI M NAKAZONO M KANNO K | 1992 | Theoretical and Applied Genet- ics1992，84，34： | 1 |
| 3 | Predictive Factors for Survival in Surgically Resected Clinical IA Peripheral Adenocarcinoma of the Lung显示文摘 | Sakao Y Nakazono T Sakuragi T | 2004 | Ann Thorac Surg2004，77，4： | 1 |
| 4 | Solitary fibrous tumor of the adrenal gland with renal cell carcinoma and angiomyolipoma at the same time; a case report] 显示文摘 | Hashizume K Matsumoto S Nakazono S | 2012 | Nihon Hinyokika Gakkai Zasshi2012，103，3： | 1 |
| 5 | ATP synthesis steady-state level inhibitorsas well as respiratory inhibitiors increase of alternative oxidase mRNA in Arabidosis thaliana 显示文摘 | Saisho D Nakazono M Tsutsumi N Hirai A | 2001 | J Plant Physiol2001，35，： | 1 |
| 6 | Serum leptin concentration in patients on dialysis显示文摘 | Nakazono H Nagake Y Ichikawa H | 1998 | Nephrol1998，80，1： | 1 |
| 7 | Immunity to rice black streaked dwarf virus, a plant reovirus, can be a- chieved in rice plants by RNA silencing against the gene for the viroplasm component protein 显示文摘 | Shimizu T Nakazono - Nagaoka E Akita F | 2011 | Virus Research2011，160，12： | 1 |
| 8 | Relationship between incubation days and rearing temperature of Octopus vulgaris eggs 显示文摘 | Sakaguchi H Hamano T Nakazono A | 1999 | Bull J Soc Fish Oceanogr1999，63，4： | 1 |
| 9 | Predictive factors for survival in surgically resected clinical IA peripheral adenocarcinoma of the lung显示文摘 | Sakao Y Nakazono T Sakuragi T | 2004 | Ann Thorac Surg2004，77，4： | 1 |
| 10 | Separated transcriptomes of male gametophyte and tapetum in rice : Validity of a laser microdissection (LM) microarray 显示文摘 | Suwabe K Suzuki G Takahashi H Shiono K Endo M Yano K Fujita M Masuko H Saito H Fujioka T Kaneko F Kazama T Mizuta Y Kawagishi-Kobayashi M Tsutsumi N Kurata N Nakazono M Watanabe M | 2008 | Plant and Cell Physiology2008，49，10： | 1 |
| 11 | Does superoxide underlie the pathogenesis of hypertension?显示文摘 | Nakazono K Watanabe N Matsuno K | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
| 12 | Molecular and cellular characterizations of a cDNA clone encoding a novel isozyme of aldehyde dehydrogenase from rice显示文摘 | Li Y Nakazono M Tsutsumi N Hirai A | | 0，，： | 1 |
| 13 | Enhanced resistance to blast (Magnaporthe grisea) in transgenic japonica rice by constitutive expression office chitinase 显示文摘 | NisMzawa Y Nishio Z Nakazono K | 1999 | Theor Appl Genet1999，99，： | 1 |
| 14 | Vibration control of load for rotary crane system using neural network with GA- based training显示文摘 | Nakazono K Ohnishi K Kinjo H | 2008 | Artificial Life and Robotics2008，13，： | 1 |
| 15 | Synthesis of photosensitive Luminol releasing compound Luminol-O-2-nitrobenzylate显示文摘 | Nakazono M Asechi M Zaitsu K | 2004 | Photochem Photobiol Chem2004，，163： | 1 |
| 16 | Persistent Mtillerian duct syndrome suggested by magnetic resonance imaging 显示文摘 | Otsuka T Nakazono T Matsuo Y | 2003 | Radiat Med2003，21，： | 1 |
| 17 | Enhanced resistance to blast (Magnaporthe grisea)in transgenic Japonica Rice by constitutive expression of rice chitinase显示文摘 | Nishizawa Y Nishio Z Nakazono K | 1999 | Theor Appl Genet1999，99，： | 1 |
| 18 | Serum leptin concentratlons in patients on hemodialysis 显示文摘 | Nakazono H Nagake Y Ichikawa H | 1998 | Naphron1998，80，1： | 1 |
| 19 | Mechanical properties of WC/Co cemented carbide with larger WC grain size显示文摘 | Okamoto S Nakazono Y Otsuka K | 2005 | Materials Char- acterization2005，55，45： | 1 |
| 20 | Expression of a gene encoding mitochondrial aldehyde dehydrogenase in rice increases under submerged conditions显示文摘 | Nakazono M Tsuji H Li Y H Saisho D Arimura S Tsutsumi N Hirai A | | 0，，2： | 1 |
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