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| 1 | 钢筋与钢纤维混凝土的黏结-滑移性能及其关系模型显示文摘基于内贴应变片的钢筋与钢纤维混凝土局部黏结试件的拉拔试验,研究钢筋与不同强度钢纤维混凝土的黏结性能。通过对实测钢筋应变的分析,建立了以三次多项式表达的黏结应力分布函数,得到了各级荷载作用下钢筋与钢纤维混凝土黏结应力和相对滑移沿黏结区段的分布,进一步分析了钢纤维和混凝土强度对黏结性能的影响。结果表明,随钢纤维的体积率和混凝土强度的增大,黏结试件加载端附近的黏结应力提高,黏结应力极值总体向加载端靠拢;同时,加载端与自由端的滑移减小。最后,提出了能够较好反映钢筋与钢纤维混凝土受力过程的黏结-滑移关系模型。 | 高丹盈 陈刚 Hadi Muhammad Najib Sadraddin 赵亮平 王伟强 李琛 | 2015 | 建筑结构学报2015，36，7： | 25 |
| 2 | Strongly Gorenstein Flat Modules and Dimensions显示文摘There is a variety of nice results about strongly Gorenstein flat modules over coherent rings. These results are done by Ding, Lie and Mao. The aim of this paper is to generalize some of these results, and to give homological descriptions of the strongly Gorenstein flat dimension (of modules and rings) over arbitrary associative rings. | Najib MAHDOU Mohammed TAMEKKANTE | 2011 | Chinese Annals of Mathematics,Series B2011，32，4： | 14 |
| 3 | 在结肠和直肠的癌症的淋巴节点收获: 当前的考虑显示文摘 The prognostic significance of identifying lymph node(LN) metastases following surgical resection for colon and rectal cancer is well recognized and is reflected in accurate staging of the disease.An established body of evidence exists,demonstrating an association between a higher total LN count and improved survival,particularly for node negative colon cancer.In node positive disease,however,the lymph node ratios may represent a better prognostic indicator,although the impact of this on clinical treatment has yet to be universally established.By extension,strategies to increase surgical node harvest and/or laboratory methods to increase LN yield seem logical and might improve cancer staging.However,debate prevails as to whether or not these extrapolations are clinically relevant,particularly when very high LN counts are sought.Current guidelines recommend a minimum of 12 nodes harvested as the standard of care,yet the evidence for such is questionable as it is unclear whether an increasing the LN count results in improved survival.Findings from modern treatments,including down-staging in rectal cancer using pre-operative chemoradiotherapy,paradoxically suggest that lower LN count,or indeed complete absence of LNs,are associated with improved survival;implying that using a specific number of LNs harvested as a measure of surgical quality is not always appropriate.The pursuit of a sufficient LN harvest represents good clinical practice;however,recent evidence shows that the exhaustive searching for very high LN yields may be unnecessary and has little in? uence on modern approaches to treatment. | James R McDonald Andrew G Renehan Sarah T O’Dwyer Najib Y Haboubi | 2012 | World Journal of Gastrointestinal Surgery2012，4，1： | 8 |
| 4 | 钢筋与钢纤维混凝土黏结强度计算方法研究显示文摘根据钢纤维混凝土具有较大变形和裂缝扩展能力的特点,建立了钢纤维混凝土环向伸长的表达式。在此基础上,将弹性力学理论、虚拟裂缝理论与钢纤维混凝土软化模型相结合,提出了钢筋与钢纤维混凝土黏结强度的计算方法,并进行了试验验证,同时分析了相对保护层厚度(混凝土保护层厚度与钢筋直径之比)、裂缝数量和钢筋直径对相对黏结强度(黏结强度与钢纤维混凝土抗拉强度之比)的影响。结果表明,钢筋与钢纤维混凝土相对黏结强度处于塑性状态解和部分开裂弹性状态解之间;钢纤维体积率在0.5%~1.5%时,随着黏结试件相对保护层厚度的增大和裂缝数量的增多,相对黏结强度增大;随着钢筋直径的增大,相对黏结强度减小。但当裂缝数量大于5或钢筋直径大于32 mm,裂缝数量和钢筋直径的变化对相对黏结强度的影响较小。 | 高丹盈 陈刚 汤寄予 HADI Muhammad Najib Sadraddin 赵亮平 | 2018 | 建筑结构学报2018，39，9： | 8 |
| 5 | Split-dose vs same-day reduced-volume polyethylene glycol electrolyte lavage solution for morning colonoscopy显示文摘AIM:To compare same-day whole-dose vs split-dose of 2-litre polyethylene glycol electrolyte lavage solution(PEG-ELS)plus bisacodyl for colon cleansing for morning colonoscopy.METHODS:Consecutive adult patients undergoing morning colonoscopy were allocated into two groups i.e.,same-day whole-dose or split-dose of 2-litre PEGELS.Investigators and endoscopists were blinded to the allocation.All patients completed a questionnaire that was designed by Aronchick and colleagues to assess the tolerability of the bowel preparation regime used.In addition,patients answered an ordinal fivevalue Likert scale question on comfort level during bowel preparation.Endoscopists graded the quality of bowel preparation using the Boston bowel preparation scale(BBPS).In addition,endoscopists gave an overall grading of the quality of bowel preparation.Cecal intu-bation time,withdrawal time,total colonoscopy time,adenoma detection rate and number of adenomas detected for each patient were recorded.Sample size was calculated using an online calculator for binary outcome non-inferiority trial.Analyses was based upon intent-to-treat.Significance was assumed at P-value<0.05.RESULTS:Data for 295 patients were analysed.Mean age was 62.0±14.4 years old and consisted of 50.2%male.There were 143 and 152 patients in the split-dose and whole-dose group,respectively.Splitdose was as good as whole-dose for quality of bowel preparation.The total BBPS score was as good in the split-dose group compared to the whole-dose group[6(6-8)vs 6(6-7),P=0.038].There was no difference in cecal intubation rate,cecal intubation time,withdrawal time,total colonoscopy time and adenoma detection rate.Median number of adenoma detected was marginally higher in the split-dose group[2(1-3)vs 1(1-2),P=0.010].Patients in the whole-dose group had more nausea(37.5%vs 25.2%,P=0.023)and vomiting(16.4%vs 8.4%,P=0.037),and were less likely to complete the bowel preparation(94.1%vs 99.3%,P=0.020).Patients in the split-dose group were less likely to refuse the same bowel preparation regime(6.3%vs 13.8%,P=0.033)and less likely to want to try another bowel preparation regime(53.8%vs 78.9%,P<0.001).CONCLUSION:Splitting reduced-volume PEG-ELS for morning colonoscopy is as effective as taking the whole dose on the same morning but is better tolerated and preferred by patients. | Wah-Kheong Chan Najib Azmi Sanjiv Mahadeva Khean-Lee Goh | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 6 | 美洲大蠊多肽PAE2逆转BEL-7402/5-FU细胞多药耐药性的作用及机制研究显示文摘本研究探讨了美洲大蠊多肽PAE2逆转人肝细胞肿瘤耐药细胞株BEL-7402/5-FU的多药耐药性作用及机制。以人肝细胞肿瘤敏感细胞株BEL-7402、人肝细胞肿瘤耐5-氟尿嘧啶(5-FU)细胞株BEL-7402/5-FU和Balb/c-nude小鼠为研究对象,采用噻唑蓝比色分析法检测BEL-7402/5-FU细胞的多药耐药性和交叉耐药性,通过激光共聚焦显微镜观察阿霉素在BEL-7402/5-FU细胞中的累积。使用实时荧光定量聚合酶链式反应和免疫细胞化学染色法检测BEL-7402/5-FU细胞中P-糖蛋白1(P-glycoprotein 1,P-gp1)、多药耐药相关蛋白1(multi-drug resistance protein 1,MRP1)、肺耐药相关蛋白1(lung resistance protein 1,LRP1)以及乳腺癌耐药蛋白1(breast cancer resistance protein 1,BCRP1)的mRNA和蛋白的相对表达量,确定美洲大蠊多肽PAE2逆转多药耐药性的机制。此外,在Balb/c-nude小鼠中,建立BEL-7402/5-FU细胞的腋下移植瘤模型,观察美洲大蠊多肽PAE2对腋下移植瘤小鼠的免疫器官、肝肾功能、肿瘤抑制与诱导肿瘤细胞调亡、调节肿瘤组织多药耐药相关蛋白等环节的影响。结果显示,美洲大蠊多肽PAE2能有效逆转BEL-7402/5-FU细胞的多药耐药性和交叉耐药性,作用机制可能与下调多药耐药相关蛋白的表达水平有关,降低了多药耐药细胞对抗肿瘤药物的外排能力、影响抗肿瘤药物分子代谢,从而达到逆转人肝细胞癌多药耐药的作用。 | 王彦权 李彩琳 NAJIB Mohammerd 彭芳 吴定宇 | 2021 | 中国医药工业杂志2021，52，1： | 5 |
| 7 | Neural Network Based Adaptive Tracking Control for a Class of Pure Feedback Nonlinear Systems With Input Saturation显示文摘In this paper, an adaptive neural networks(NNs)tracking controller is proposed for a class of single-input/singleoutput(SISO) non-affine pure-feedback non-linear systems with input saturation. In the proposed approach, the original input saturated nonlinear system is augmented by a low pass filter.Then, new system states are introduced to implement states transformation of the augmented model. The resulting new model in affine Brunovsky form permits direct and simpler controller design by avoiding back-stepping technique and its complexity growing as done in existing methods in the literature.In controller design of the proposed approach, a state observer,based on the strictly positive real(SPR) theory, is introduced and designed to estimate the new system states, and only two neural networks are used to approximate the uncertain nonlinearities and compensate for the saturation nonlinearity of actuator. The proposed approach can not only provide a simple and effective way for construction of the controller in adaptive neural networks control of non-affine systems with input saturation, but also guarantee the tracking performance and the boundedness of all the signals in the closed-loop system. The stability of the control system is investigated by using the Lyapunov theory. Simulation examples are presented to show the effectiveness of the proposed controller. | Nassira Zerari Mohamed Chemachema Najib Essounbouli | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 5 |
| 8 | 美洲大蠊提取物逆转人肝癌细胞HepG2/ADM多药耐药的机制研究显示文摘目的:研究美洲大蠊提取物脱脂膏及CⅡ-3(分别简称'脱脂膏''CⅡ-3')逆转耐阿霉素(ADM)人肝癌细胞HepG2/ADM多药耐药的作用机制。方法:采用MTT法考察不同质量浓度索拉非尼(阳性对照)、脱脂膏和CⅡ-3对HepG2/ADM细胞的毒性作用,并计算20%抑制浓度(IC20)。试验设置敏感组、耐药组、索拉非尼组、脱脂膏组和CⅡ-3组,敏感组使用HepG2细胞,后4组均使用HepG2/ADM细胞。敏感组和耐药组细胞给予常规培养基,其余3组细胞给予相应药物(浓度均为IC20)。采用激光扫描共聚焦显微技术测定细胞中ADM含量;采用Western blotting法测定细胞中凋亡相关蛋白[B细胞淋巴瘤2(Bcl-2)、剪切型胱天蛋白酶9 p37(Cleaved-Caspase-9 p37)]的表达水平;分别采用实时荧光定量-聚合酶链式反应法和免疫细胞化学染色法检测细胞中多药耐药相关基因mRNA及蛋白[P-糖蛋白(P-gp)(MDR1基因表达产物)、肺耐药蛋白(LRP)、乳腺癌耐药相关蛋白(BCRP)]和酶介导多药耐药途径中相关基因mRNA及蛋白[谷胱甘肽转移酶(GST-π)、DNA拓扑异构酶Ⅱ(TopoⅡ)]的表达水平。结果:索拉非尼、脱脂膏、CⅡ-3对HepG2/ADM细胞的IC20分别为(2.40±0.16)、(200.44±27.52)、(18.00±1.82)μg/mL。与敏感组比较,耐药组细胞中Bcl-2、P-gp、LRP、BCRP、TopoⅡ蛋白表达水平以及MDR1、LRP、BCRP、GST-πm RNA表达水平均显著升高(P<0.05或P<0.01)。与耐药组比较,脱脂膏组和CⅡ-3组细胞中ADM含量显著增加(P<0.05或P<0.01),MDR1 m RNA表达水平和LRP、BCRP、GST-πm RNA及其蛋白表达水平均显著降低(P<0.05或P<0.01);CⅡ-3组细胞中Bcl-2蛋白表达水平、TopoⅡmRNA表达水平均显著降低(P<0.01),Cleaved-Caspase-9 p37蛋白表达水平显著升高(P<0.05)。结论:脱脂膏、CⅡ-3可通过减少药物外排、促进细胞凋亡、减少多药耐药相关基因和酶介导多药耐药途径中相关基因的mRNA及其蛋白的表达等方式,逆转HepG2/ADM细胞的多药耐药性,且CⅡ-3的效果优于脱脂膏。 | 李彩琳 吴定宇 吕鸿 张鸿翰 王彦权 Najib Mohammerd 彭芳 | 2020 | 中国药房2020，31，15： | 4 |
| 9 | 美洲大蠊多肽PAE_(2)逆转耐药细胞株多药耐药性的研究显示文摘目的:探讨美洲大蠊多肽PAE2逆转人肝细胞癌耐药细胞株BEL-7402/5-FU多药耐药性的作用及机制。方法:以人肝细胞癌敏感细胞株BEL-7402和人肝细胞癌耐药细胞株BEL-7402/5-FU为研究对象。采用噻唑蓝比色法(methyl thiazolyl tetrazolium,MTT)检测细胞活力;荧光定量聚合酶链式反应(real time-polymerase chain reaction,RT-PCR)和免疫细胞化学染色法检测细胞中谷胱甘肽-S-转移酶(glutathione S-transferase-π,GST-π)、DNA拓扑异构酶Ⅱ(topo-isomerase typeⅡ,TopoⅡ)和蛋白激酶C(protein kinase C,PKC)的mRNA和蛋白的相对表达量。结果:美洲大蠊多肽PAE2能有效逆转人肝细胞癌耐药细胞BEL-7402/5-FU的多药耐药性,能下调多药耐药相关酶PKC、GST-π、TopoⅡ的mRNA和蛋白表达水平。结论:PAE2在体外逆转多药耐药的作用机制可能与下调多药耐药相关酶有关。 | 王彦权 张鸿翰 吕鸿 李彩琳 Najib Mohammerd 彭芳 吴定宇 | 2021 | 大理大学学报2021，6，8： | 4 |
| 10 | 中美植筋锚固技术对比分析显示文摘为了对比中美植筋锚固技术规范中的异同,并为今后国际结构加固工程设计提供参考经验,结合摩洛哥某电厂改造项目,从植筋锚固构造要求和承载力设计值两个方面进行对比分析,并介绍了按美标规范进行的植筋锚固施工。研究结果发现:中美规范对植筋锚固技术的构造要求大体相同;但与美标相比,按中标计算的抗拉和抗剪承载力设计值偏保守。 | 刘树明 丁志全 Amziane Mohamed Najib | 2014 | 水运工程2014，，2： | 3 |
| 11 | Review: Progress and Trends in Ultrasonic Vibration Assisted Friction Stir Welding显示文摘This paper aims to reviewthe state-of-the-art of ultrasonic vibration assisted friction stir welding(UVAFSW) process. Particular attention has been paid on the modes of ultrasonic exertion,experimental results and effects of ultrasonic vibrations on process effectiveness and joint quality. The trends of various aspects with and without ultrasonic vibrations in FSW process are studied and presented. The influence of ultrasonic vibrations on welding loads, temperature history, weld morphology, material flow, weld microstructure and mechanical properties are revisited. Ultrasonic assisted FSW offers numerous advantages over the conventional FSW process. The superimposing of high-frequency vibrations improves various phenomena of the process and the physical,metallurgical,mechanical and tribological properties of the welded joint. The ultrasonic assisted FSW process has a potential to benefit the industry sector. A checklist listing the materials and process parameters used in the documented studies has been presented for quick reference. | Najib Ahmad Muhammad Chuansong Wu Girish Kumar Padhy | 2018 | Journal of Harbin Institute of Technology(New Series)2018，25，3： | 3 |
| 12 | 消失的马来西亚传统建筑智慧的再发现——但是否太迟?显示文摘前言本文概述了马来西亚建筑理论家在协助进行遗产研究时意识到:这个国家正在失去一个巨大的宝库——建筑遗产。当我们匆忙拥抱那些现代事物及其表现出的便捷性与先进性时,我们有时会忽视。 | Ahmad Najib Ariffin Mohd.Zulhemlee An 刘宗刚 | 2010 | 建筑与文化2010，，11： | 3 |
| 13 | Hepatitis C and kidney disease:An overview and approach to management显示文摘Hepatitis C infection and chronic kidney disease are major health burden worldwide. Hepatitis C infection is associated with a wide range of extra-hepatic manifestations in various organs including the kidneys. A strong association between hepatitis C and chronickidney disease has come to light. Hemodialysis in supporting the end stage renal disease patients unfortunately carries a risk for hepatitis C infection. Despite much improvement in the care of this group of patients,the prevalence of hepatitis C infection in hemodialysis patients is still higher than the general population. Hepatitis C infection has a negative effect on the survival of hemodialysis and renal transplant patients. Treatment of hepatitis C in end stage renal disease patients using conventional or pegylated interferon with or without ribavirin remains a clinical challenge with low response rate,high dropout rate due to poor tolerability and many unmet needs. The approval of new direct acting antiviral agents for hepatitis C may dramatically change the treatment approach in hepatitis C infected patients with mild to moderate renal impairment. However it remains to be confirmed if the newer Hepatitis C therapies are safe in individuals with severe renal impairment. This review article discusses the relationship between hepatitis C and chronic kidney disease,describe the various types of renal diseases associated with hepatitis C and the newer as well as the existing treatments for hepatitis C in the context of this subpopulation of hepatitis C patients. | Ahmad Najib Azmi Soek-Siam Tan Rosmawati Mohamed | 2015 | World Journal of Hepatology2015，7，1： | 3 |
| 14 | Practical approach in hepatitis b e antigen-negative individuals to identify treatment candidates显示文摘The natural history of chronic hepatitis B is characterized by different phases of infection,and patients may evolve from one phase to another or may revert to a previous phase.The hepatitis B e antigen(HBeAg)-negative form is the predominant infection worldwide,which consists of individuals with a range of viral replication and liver disease severity.Although alanine transaminase(ALT)remains the most accessible test available to clinicians for monitoring the liver disease status,further evaluations are required for some patients to assess if treatment is warranted.Guidance from practice guidelines together with thorough investigations and classifications of patients ensure recognition of who needs which level of care.This article aims to assist physicians in the assessment of HBeAgnegative individuals using liver biopsy or non-invasive tools such as hepatitis B s antigen quantification and transient elastography in addition to ALT and hepatitis B virus DNA,to identify who will remain stable,who will reactivate or at risk of disease progression hence will benefit from timely initiation of anti-viral therapy. | Ahmad Najib Azmi Soek-Siam Tan Rosmawati Mohamed | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 15 | Endoscopic treatment of iatrogenic gastrointestinal perforations: An overview显示文摘 | Najib Al Ghossaini Damien Lucidarme Philippe Bulois | 2013 | Digestive and Liver Disease2013，，： | 2 |
| 16 | Adaptive Fuzzy Sliding Mode Power System Stabilizer Using Nussbaum Gain显示文摘Power system stability is enhanced through a novel stabilizer developed around an adaptive fuzzy sliding mode approach which applies the Nussbaum gain to a nonlinear model of a single-machine infinite-bus (SMIB) and multi-machine power system stabilizer subjected to a three phase fault. The Nussbaum gain is used to avoid the positive sign constraint and the problem of controllability of the system. A comparative simulation study is presented to evaluate the achieved performance. | Emira Nechadi Mohamed Naguib Harmas Najib Essounbouli Abdelaziz Hamzaoui | 2013 | International Journal of Automation and computing2013，10，4： | 2 |
| 17 | Pelvic radiation therapy: Between delight and disaster显示文摘In the last few decades radiotherapy was established as one of the best and most widely used treatmentmodalities for certain tumours. Unfortunately that came with a price. As more people with cancer survive longer an ever increasing number of patients are living with the complications of radiotherapy and have become, in certain cases, difficult to manage. Pelvic radiation disease(PRD) can result from ionising radiationinduced damage to surrounding non-cancerous tissues resulting in disruption of normal physiological functions and symptoms such as diarrhoea, tenesmus, incontinence and rectal bleeding. The burden of PRDrelated symptoms, which impact on a patient's quality of life, has been under appreciated and sub-optimally managed. This article serves to promote awareness of PRD and the vast potential there is to improve current service provision and research activities. | Kirsten AL Morris Najib Y Haboubi | 2015 | World Journal of Gastrointestinal Surgery2015，7，11： | 2 |
| 18 | Interferon-lb therapy in idiopathic pulmonary fibrosis 显示文摘 | Edan K B Najib T A Michael S | 2005 | Chest2005，128，1： | 1 |
| 19 | Epicardial fat can mimic peri-cardial effusion on transoesophageal echocardiogram显示文摘 | Najib MQ Ganji JL Raizada A | 2011 | Eur J Echocar-diogr2011，12，10： | 1 |
| 20 | Dose-dependent attenuation of auditory phantom perception(tinnitus)by PET-guided repetitive transcranial magnetic stimulation显示文摘 | PLEWNIA C REIMOLD M NAJIB A | 2007 | Hum Brain Mapp2007，28，： | 1 |
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