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| 1 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 2 | Primary peritonitis in children with nephrotic syndrome 显示文摘 | Lasry F Badre A Naim A et ol | 2005 | Nephrol Ther2005，1，5： | 1 |
| 3 | Thin-layer chromatography of some ergot alkaloids显示文摘 | SALLAM L A R NAIM N EI-REFAI A H | 1977 | Fresenius J Anal Chem1977，284，： | 1 |
| 4 | On the Use of Planar Shear-lag Methods for Stress-transfer Analysis of Multilayered Composites 显示文摘 | Naim J A Mondels D A | 2001 | Mechanics of Materials (S0167-6636)2001，33，6： | 1 |
| 5 | Argonaute 2- null embryonic stem cells are retarded in self-renewal and differ- entiation显示文摘 | SHEKAR P C NAIM A SARATHI D P | 2011 | J Biosei2011，36，64： | 1 |
| 6 | Energy Management Strategies for Parallel Hybrid Vehicles Using Fuzzy Logic 显示文摘 | NIELS J Schouten MUTASIM A Salman NAIM A Kheir | 2003 | Control Engineering Practice2003，，1： | 1 |
| 7 | Shiga toxin activates complement and binds factor H:evidence for an active role of complement in hemolytic uremic syndrome 显示文摘 | Orth D Khan AB Naim A | 2009 | J Immunol2009，182，： | 1 |
| 8 | Cardiac matrix remodelling in congestive heart failure: the role of matrix metalloproteinases 显示文摘 | ABOU-RAYA S NAIM A MARZOUK S | 2004 | Clin Invest Med2004，27，： | 1 |
| 9 | Energy Management Strategies for Parallel Hybrid Vehicles Using Fuzzy Logic显示文摘 | NIELS J S MUTASIM A S NAIM A K | 2002 | Control Engineering Practice2002，10，8： | 1 |
| 10 | Antioxidative and antihemolytic activities of soybean isoflavones显示文摘 | Naim M Gestetner B Bondi A | 1976 | Agric Food Chem1976，24，6： | 1 |
| 11 | Assessing the impact of cost optimization based on infrastructure modeling on CO2 emissions显示文摘 | Harris I Naim M Palmerc A | 2011 | International Journal of Production Economics2011，131，1： | 1 |
| 12 | Fuzzy Logic Control for Parallel Hybrid Vehicles 显示文摘 | Schouten Niels T Salman Mutasim A Kheir Naim A | 2002 | IEEE Transactions on Control Systems Technology2002，10，3： | 1 |
| 13 | Cardiac matrix remodelling in congestive heart failure:the role of matrix metalloproteinase显示文摘 | Abou-Raya S Naim A Marzouk S | 2004 | Clin Invest Med2004，27，2： | 1 |
| 14 | Fuzzy logic control for parallel hybrid vehicles显示文摘 | NIELS J S MUTASIM A S NAIM A K | 2002 | IEEE Transactions on Control Systems Technology2002，10，3： | 1 |
| 15 | Production of phosphorylation state-specific antibodies 显示文摘 | Czemik A J Naim A C | 1991 | Methods Enzymol1991，201，： | 1 |
| 16 | Assessing the Impact of E-business on Supply Chain Dynamics 显示文摘 | Disney SM Naim MM Potter A | 2004 | International Journal of Production Economics2004，，1： | 1 |
| 17 | Dispersive micro-solid phase extraction method using newly prepared poly (methyl methacrylate) grafted agarose combined with ICP-MS for the simultaneous determination of Cd, Ni, Cu and Zn in vegetable and natural water samples显示文摘 | POURMAND N SANAGI M M NAIM A A | 2015 | Analytical Methods2015，7，7： | 1 |
| 18 | Antioxidative and antihemolyticactivitics of soybean isoflavones显示文摘 | NAIM M GESTENER B BONDI A | 1976 | J Agne Food Chem1976，24，： | 1 |
| 19 | On-line estimation of probabilities for distributed Bayesian detection显示文摘 | Naim A Kam M | 1994 | Automatica1994，30，4： | 1 |
| 20 | Antioxidantive and antiheolytic activites of soybean isoflavones显示文摘 | Naim M Gestetner B Bondi A | 1976 | Agric Food Chem1976，24，： | 1 |
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