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| 1 | Expression of Interleukin-11 and Interleukin-11 receptor a in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors显示文摘AIM: There is strong evidence that interleukin-11 (IL-11) is involved in the regulation of tumor progression, cellular growth and differentiation. Recently, interleukin-11 receptor (IL-11R) has been detected on some cancer cells. In this study, we investigated the expression of IL-11 and IL-11R in colorectal adenocarcinoma. METHODS: To elucidate the involvement of IL-11 and IL-11Ra in human intestinal adenocarcinomas, we examined 115 cases of surgically resected human colonic adenocarcinoma and 11 cases of adenoma by immuno-histochemistry and Western blotting. RESULTS: Among 115 cases of adenocarcinoma, 100 cases (87.0%) showed positive staining in the cytoplasm of carcinoma cells for the IL-11, and 87 cases (75.6%) were positive for the IL-11Ra. Six cases (54.5%) and four cases (36.4%) of 11 adenomas were positive for IL-11 and IL-11Ra, respectively. The expression of IL-11Ra correlated with the histological differentiation (P=0.033503), the depth of tumor invasion (P=0.006395), Dukes' classification (P= 0.015648) and lymphatic invasion (P=0.003865). However, the expression of IL-11Ra was not correlated with the venous invasion and the presence of lymph node metastasis. The expression of IL-11 was not correlated with any clinicopathological factors. In Western blot analysis, two human colorectal carcinoma cell lines and four tissues of surgically resected human carcinoma expressed both IL-11 and IL-11Ra proteins. CONCLUSION: IL-11 and IL-11Ra are highly expressed in human colorectal adenocarcinoma and the IL-11Ra expression is correlated with clinicopathological factors. These findings suggest that the expression of IL-11Ra is an important factor for the invasion of human colorectal adenocarcinoma. | Kazuyuki Yamazumi Toshiyuki Nakayama Takafumi Kusaba Chun Yang Wen Ayumi Yoshizaki Yuichi Yakata Takeshi Nagayasu Ichiro Sekine | 2006 | World Journal of Gastroenterology2006，12，2： | 7 |
| 2 | Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma显示文摘AIM: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocellular carcinoma (HCC) patients who underwent hepatectomy based on our preliminary study. METHODS: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modifi ed Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. RESULTS: Median MVC was 178/mm^2, which was used as a cut-off value. MVC was not signif icantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox’s multivariateanalysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic fi nding and hepatic dysfunction. Signifi cant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. CONCLUSION: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2. | Atsushi Nanashima Toshiyuki Nakayama Yorihisa Sumida Takafumi Abo Hiroaki Takeshita Kenichirou Shibata Shigekazu Hidaka Terumitsu Sawai Toru Yasutake Takeshi Nagayasu | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 3 | Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score显示文摘AIM: To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score (mJIS).METHODS: We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy.RESULTS: Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group (P < 0.05). The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a mJIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower.CONCLUSION: According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC. | Atsushi Nanashima Junichi Masuda Satoshi Miuma Yorihisa Sumida Takashi Nonaka Kenji Tanaka Shigekazu Hidaka Terumitsu Sawai Takeshi Nagayasu | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 4 | A case of intrahepatic clear cell cholangiocarcinoma显示文摘Intrahepatic clear cell cholangiocarcinoma is very rareonly 8 cases have been reported.A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging,and hepatic segmentectomy was performed.Histopathologically,the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests.These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma.Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen,not mucin nor lipid.On immunohistochemical staining,cytokeratin(CK)7 and CK19 were positive,whereas CK20 was negative.Vimentin was detected on the cell membranes,and CD56 was focally positive.The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively.Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown. | Eo Toriyama Atsushi Nanashima Hideyuki Hayashi Kuniko Abe Naoe Kinoshita Shunsuke Yuge Takeshi Nagayasu Masataka Uetani Tomayoshi Hayashi | 2010 | World Journal of Gastroenterology2010，16，20： | 2 |
| 5 | High expression of trimethylated histone H3 at lysine 27 predicts betterprognosis in non-small cell lung cancer显示文摘 | Xiaohui Chen Ning Song Keitaro Matsumoto Atsushi Nanashima Takeshi Nagayasu Tomayoshi Hayashi Mingang Ying Daisuke Endo Zhiren Wu Takehiko Koji | 2013 | International Journal of Oncology2013，，5： | 2 |
| 6 | The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs显示文摘 | Nagayasu A Uchiyama K Kiwada H | 1999 | Advanced Drug Delivery Reviews1999，40，： | 2 |
| 7 | Effects of the size and fluidity of liposomes on their accumulation in tumors: a presumption of their interaction with tumors 显示文摘 | Uchiyama K Nagayasu A Yamagiwa Y | 1995 | Int J Pharm1995，121，： | 2 |
| 8 | The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposo- mal antitumor drugs 显示文摘 | NAGAYASU A UCHIYAMA K KIWADA H | 1999 | Adv Drug Delivery Rev1999，40，12： | 1 |
| 9 | An Inverse Problem for the Elastic Equation in Plane-Stratified Media 显示文摘 | Nagayasu S | 2005 | SUT Journalof Mathematics2005，41，2： | 1 |
| 10 | Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARY2 and C/EBP-α in 3T3-L1 cells显示文摘 | Furuyashiki T Nagayasu H Aoki Y | 2004 | Biosci Biotechnol Biochem2004，68，： | 1 |
| 11 | Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells 显示文摘 | Furuyashiki T Nagayasu H Aoki Y | 2004 | Biosci Biotechnol Biochem2004，68，： | 1 |
| 12 | Antiobesity actions of green tea: possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis-ralated trancription factors显示文摘 | Ashida H Furuyashiki T Nagayasu H | 2004 | Biofactors2004，221，： | 1 |
| 13 | Anti-obesityactions of green tea:possible involvements in modulation of the glucoseuptake system and suppression of the adipogenesis-related transcriptionfactors显示文摘 | ASHIDA H FURUYASHIKI T NAGAYASU H | 2004 | Biofactors2004，22，14： | 1 |
| 14 | The measurement of impact pressure and solid surface response in liquid-solid impact up to hypersonic range显示文摘 | Shi H H Takayama K Nagayasu N | 1995 | Wear1995，，： | 1 |
| 15 | Expression of keratinocyte growth factor (fibreblast growth factor-7 ) and its receptor in human lung cancer:correlation with tumor proliferation activity and patient prognosis 显示文摘 | Yamayoshi T Nagayasu T Matsumoto K | 2004 | J Pathol2004，204，： | 1 |
| 16 | Involvement ofcdc42/Rho kinase in ApoA- I -mediated cholesterol effluxthrough interaction between cytosolic lipid-protein particles andmicrotubules in rat astrocytes 显示文摘 | Kheirollah A Nagayasu Y Ueda H | 2014 | J Neurosci Res2014，92，45： | 1 |
| 17 | Diagnostic imaging Q&A Inflammatory myofibroblastic tumor显示文摘 | Miyazaki T Nagayasu T | 2013 | Kyobu Geka2013，66，2： | 1 |
| 18 | Flavonoid 5-glucosides from the cocoon shell of the silkworm, Bombyx mori显示文摘 | Yasumori Tamura Ken-ichi Nakajima Ken-ichi Nagayasu Chiyuki Takabayashi | 2002 | Phytochemistry2002，，3： | 1 |
| 19 | Adipocyte-macro- phage interaction may mediate LPS-induced low-grade inflam- mation : potential link with metabolic complications 显示文摘 | Nakarai H Yamashita A Nagayasu S | 2012 | Innate Immun2012，18，1： | 1 |
| 20 | Clinical features of intradural neurinomas in the cauda equine and around the conus medullaris 显示文摘 | Hanakita J Suwa H Nagayasu S | 1992 | Neurochirurgia (Stuttg)1992，35，5： | 1 |
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