|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 2 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Laparoscopic partial nephrectomy for central tumors:analysis of perioperative outcomes and complications显示文摘 | Nadu A Kleinmann N Laufer M | 2009 | J Urol2009，181，1： | 1 |
| 4 | A pilot study 显示文摘 | Sandhya B Thomas S Isabel W et aL Ethnomedicinal plants used by the Valaiyan community of Piranmalai Hills (Reserved Forest) Tamil Nadu India | 2006 | Afr J Tradit Com- plementAltern Med2006，3，1： | 1 |
| 5 | Testicular fixation fol- lowing torsion of the spermatic cord - does it guarantee preven- tion of recurrent torsion events 显示文摘 | Mor Y Pinthus JH Nadu A | 2006 | J Urol2006，175，1： | 1 |
| 6 | Angiotensin-Converting Enzyme 2 Activation Improves Endothelial Function显示文摘 | Rodrigo A. Fraga-Silva Fabiana P. Costa-Fraga Tatiane M. Mur?a Patrícia L. Moraes Augusto Martins Lima Roberto Q. Lautner Carlos H. Castro Célia Maria A. Soares Clayton L. Borges Ana Paula Nadu Marilene L. Oliveira Vinayak Shenoy Michael J. Katovich Robso | 2013 | Hypertension2013，，6： | 1 |
| 7 | Ventilatory and hemodynamic changes during retroperitoneal and transperitoneal laparoscopic nephrectomy: a prospective real-time comparison 显示文摘 | Nadu A Ekstein P Szold A | 2005 | Urol2005，174，3： | 1 |
| 8 | Expression of an angiotensin-(1-7) -producing fusion protein produces cardioprotective effects in rats显示文摘 | Santos RA Ferreira AJ Nadu AP | 2004 | Physiol Genomics2004，17，： | 1 |
| 9 | Expression of an angiotensin - ( 1 - 7) - producing fusion protein produces cardioprotective effects in rats显示文摘 | SANTOS RA FERREIRA A J NADU AP | 2004 | Physiol Genomics2004，17，： | 1 |
| 10 | Prospective patient-repor- ted continence after laparoscopic radical prostatectomy 显示文摘 | Olsson LE Salomon L Nadu A | 2001 | Urolo- gy2001，58，4： | 1 |
| 11 | Testicular fixation following torsion of the spermatie cord--does it guarantee prevention of recurrent torsion events?显示文摘 | Mor Y Pinthus JH Nadu A | 2006 | J Urol2006，175，1： | 1 |
| 12 | Early removal of the catheter after laparoscopic radical prostatectomy显示文摘 | Nadu A Salomon L Hoznek A | 2001 | J Urol2001，166，5： | 1 |
| 13 | Laparoscopic nephrectomy: initial experience in Israel with 110 cases显示文摘 | Nadu A Mor Y Chen J | 2005 | Isr Med Assoc J2005，7，： | 1 |
| 14 | Laparoscopic partial nephrectomy for central tumors:analysis of perioperative outcomes and complications显示文摘 | Nadu A Kleinmann N Laufer M | 2009 | J Urol2009，181，： | 1 |
| 15 | Laparoscopic partial nephrectomy for central tumors:analysis of perioperative outcomes and complications显示文摘 | Nadu A Kleinmann N Laufer M | 2009 | J Urol2009，181，1： | 1 |
| 16 | Testicular fixation following torsion of the spermatic cord-does it guarantee prevention of recurrent torsion events显示文摘 | Mor Y Pinthus JH Nadu A | | 0，，01： | 1 |
| 17 | Laparoscopic partial nephrectomy for central tumors:analysis of perioperative outcomes and complications显示文摘 | Nadu A Kleinmann N Laufer M | 2009 | J Urol2009，181，1： | 1 |
| 18 | Laparoscopic partial nephreetomy for central tumors: analysis of perio- perative outcomes and complications 显示文摘 | Nadu A Kleinmann N Laufer M | 2009 | J Urol2009，181，1： | 1 |
| 19 | Early removal of the catheter after laparoscopic radical prostatectomy显示文摘 | Nadu A Salomon L Hoznek A | 2001 | J Urol2001，166，： | 1 |
| 20 | Laparoscopic partial nephrectomy for central tumors: Analysis of perioperative outcomes and complications显示文摘 | NADU A KLEINMANN N LAUFER M | 2009 | J Urol2009，181，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员