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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three - dimensional power doppler ultra- sonoaphy显示文摘 | Mohsen I A Elkattan E Nabil H | 2013 | J Clin Ultrasound2013，41，5： | 1 |
| 4 | Effects of virgin ethylene-pro pylene-diene-monomer and its preheating time on the properties of natural rubber/recycled Ethylene-Propylene-Diene-Monomer blends显示文摘 | Nabil H Ismail H Azura A R | 2013 | Materials and Design2013，50，： | 1 |
| 5 | Mining frequent itemsets from online data streams: Comparative study 显示文摘 | Nabil H M Eldin A S Belal M A E | 2013 | International Journal of Advanced Computer Science and Applications2013，4，7： | 1 |
| 6 | Production of monoolein by immobilized Staphylococcus sirnulans lipase in a solventfree system: Optimization by response surface methodology 显示文摘 | GHAMGUI H HANEN G NABIL M | 2006 | Enzyme Microb Technol2006，39，4： | 1 |
| 7 | Reducing blood loss at abdominal myomectomy with preoperative use of dinopros- tone intravaginal suppository: a randomized placebo - con- trolled pilot study 显示文摘 | Shokeir T Shalaby H Nabil H | 2013 | Eur J Obstet Gynecol Reprod Biol2013，166，1： | 1 |
| 8 | Blending of natural rubber/recycled ethylene-propylene diene rubber: promoting the interracial adhesion between phases by natural rubber latex显示文摘 | NABIL H ISMAIL H | 2014 | Inter- national Journal of Polymer Analysis and Characterization2014，19，2： | 1 |
| 9 | An eco - friendly - nov approach for attaining wrinkle - free/soft - hand cotton fabric 显示文摘 | MOHAMED H NABIL A I AMIRA E | 2009 | Car bohydrate Polymers2009，78，： | 1 |
| 10 | Axial load tests on bored piles and pile groups in cemented sands显示文摘 | Nabil F Ismael Bengt H Fellenius | | 0，，09： | 1 |
| 11 | Compounding, me- chanical and morphological properties of carbon-black-filled natural rubber/recycled ethylene-propylene-diene-monomer (NR/R-EPDM) blends显示文摘 | NABIL H ISMAIL H AZURA A R | 2013 | Polymer Testing2013，32，2： | 1 |
| 12 | Rheological properties of high concentrations of carboxymethyl cellulose solutions显示文摘 | Mohamed Edal M Nabil Esmail Goergios H Vatistas | 2001 | Journal of Applied Polymer Science2001，79，： | 1 |
| 13 | Effects of virgin ethylene-propylene-diene-monomer and its preheating time on the properties of natural rubber/recycled ethylene-pro- pylene-diene-monomer blends 显示文摘 | NABIL H ISMAIL H AZURA A R | 2013 | Materials and Design2013，50，： | 1 |
| 14 | Optimisation of accelerators and vulcanising systems on thermal stability of natural rubber/recycled ethylene-propylene-dienemonomer blends显示文摘 | NABIL H ISMAIL H AZURA A R | 2014 | Materials and Desigl}2014，53，： | 1 |
| 15 | Optimization of accel erators on curing characteristics, tensile, and dynamic me- chanical properties of (natural rubber) / ( recycled ethylene-propylene-diene-monomer) blends显示文摘 | NABIL H ISMAIL H AZURA A R | 2015 | Journal of Vinyl and Additive Technology2015，21，2： | 1 |
| 16 | Thermo mechanical performance of natural rubber/recycled ethylene propylene-diene rubber blends in the presence of ZnO nanopartiele显示文摘 | NABIL H HANAFI I | 2015 | International Journal of Polymer Analysis and Characterization2015，20，6： | 1 |
| 17 | Enhancing the thermal stability of natural rubber/recycled ethylene-propylene-diene rubber blends by means of introducing pre-vulcanised ethylene-pro pylene-diene rubber and electron beam irradiation显示文摘 | NABIL H ISMAIL1 H | 2014 | Mate rials and Design2014，56，： | 1 |
| 18 | Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals显示文摘BACKGROUND In resource-limited countries,risk stratification can be used to optimize colorectal cancer screening.Few prospective risk prediction models exist for advanced neoplasia(AN)in true average-risk individuals.AIM To create and internally validate a risk prediction model for detection of AN in METHODS Prospective study of asymptomatic individuals undergoing first screening colonoscopy.Detailed characteristics including diet,exercise and medications were collected.Multivariate logistic regression was used to elucidate risk factors for AN(adenoma≥1 cm,villous histology,high-grade dysplasia or carcinoma).The model was validated through bootstrapping,and discrimination and calibration of the model were assessed.RESULTS 980 consecutive individuals(51%F;49%M)were enrolled.Adenoma and AN detection rates were 36.6%(F 29%:M 45%;P<0.001)and 5.1%(F 3.8%;M 6.5%)respectively.On multivariate analysis,predictors of AN[OR(95%CI)]were age[1.036(1.00-1.07);P=0.048],BMI[overweight 2.21(0.98-5.00);obese 3.54(1.48-8.50);P=0.018],smoking[<40 pack-years 2.01(1.01-4.01);≥40 pack-years 3.96(1.86-8.42);P=0.002],and daily red meat consumption[2.02(0.92-4.42)P=0.079].Nomograms of AN risk were developed in terms of risk factors and age separately for normal,overweight and obese individuals.The model had good discrimination and calibration.CONCLUSION The prevalence of adenoma and AN in average-risk Lebanese individuals is similar to the West.Age,smoking,and BMI are important predictors of AN,with obesity being particularly powerful.Though external validation is needed,this model provides an important platform for improved risk-stratification for screening programs in regions where universal screening is not currently employed. | Ala I Sharara Ali El Mokahal Ali H Harb Natalia Khalaf Fayez S Sarkis Mustapha M El-Halabi Nabil M Mansour Ahmad Malli Robert Habib | 2020 | World Journal of Gastroenterology2020，26，37： | 1 |
| 19 | Evaluation of Frequency Dependent Rubber Mount Stiffness and Damping by Impact Test显示文摘 | Lin Tianran Farag Nabil H Pan Jie | 2005 | Applied Acoustics2005，，66： | 1 |
| 20 | Resting energy expenditure in patients with alcoholic chronic pancreatitis显示文摘 | Dr. Xavier Hébuterne MD Patrick Hastier MD Jean-Luc Péroux MD Nabil Zeboudj MD Jean-Pierre Delmont MD Patrick Rampal MD | 1996 | Digestive Diseases and Sciences1996，，3： | 1 |
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