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| 1 | Morphological and functional evaluation of chronic pancreatitis with magnetic resonance imaging显示文摘Magnetic resonance imaging(MRI)techniques for assessment of morphology and function of the pancreas have been improved dramatically the recent years and MRI is very often used in diagnosing and follow-up of chronic pancreatitis(CP)patients.Standard MRI including fat-suppressed T1-weighted and T2-weighted imaging techniques reveal decreased signal and glandular atrophy of the pancreas in CP.In contrast-enhanced MRI of the pancreas in CP the pancreatic signal is usually reduced and delayed due to decreased perfusion as a result of chronic inflammation and fibrosis.Thus,morphological changes of the ductal system can be assessed by magnetic resonance cholangiopancreatography(MRCP).Furthermore,secretin-stimulated MRCP is a valuable technique to evaluate side branch pathology and the exocrine function of the pancreas and diffusion weighted imaging can be used to quantify both parenchymal fibrotic changes and the exocrine function of the pancreas.These standard and advanced MRI techniques are supplementary techniques to reveal morphological and functional changes of the pancreas in CP.Recently,spectroscopy has been used for assessment of metabolite concentrations in-vivo in different tissues and may have the potential to offer better tissue characterization of the pancreas.Hence,the purpose of the present review is to provide an update on standard and advanced MRI techniques of the pancreas in CP. | Tine Maria Hansen Matias Nilsson Mikkel Gram Jens Brφndum Frφkjr | 2013 | World Journal of Gastroenterology2013，19，42： | 7 |
| 2 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 3 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 4 | Priori strain discrimination using luminescent conjugated polymers显示文摘 | Christina J Sigurdson K Peter R Nilsson Simone Hornemann | 2007 | Nature Metheds2007，1，12： | 1 |
| 5 | Lifetime quenching in Yb doped fibres显示文摘 | Paschotta R Nilsson J Barber P R | 1995 | Optics Communications1995，136，4： | 1 |
| 6 | Stress hormones regulate IL-6 expression by human ovarian carcinoma cells through a SRC-dependent mechanism 显示文摘 | Nilsson MB Armaiz-Pena G Takahashi R | 2007 | J Biol Chem2007，282，29： | 1 |
| 7 | Finite element simulation of the manufacturing process chain of a sheet metal assembly显示文摘 | Govik A Nilsson L Moshfregh R | 2012 | Journal of Materials Processing Technology2012，212，7： | 1 |
| 8 | Helicobacterpylori infec-tion and gastroesophageal reflux in a population-based study(TheHUNT study)显示文摘 | Nordenstede H Nilsson M Johnsen R | 2007 | Helicobacter2007，12，1： | 1 |
| 9 | Ytterbiumdoped fiber amplifiers 显示文摘 | PASCHOTTA R NILSSON J TROPPER A C | 1997 | IEEE Journal of Quantum Electronics1997，33，7： | 1 |
| 10 | Simulating DCB,ENF and MMB experiments using shell elements and a cohesive zone model显示文摘 | Borg R Nilsson L Simonsson K | | 0，，02： | 1 |
| 11 | Dissecting the plant transcriptome and the regulatory responses to phosphate deprivation显示文摘 | Nilsson L Muller R Nielsen T H | 2010 | Physiology Plant2010，，139： | 1 |
| 12 | Consequences of propagule dispersal and river fragmentation for riparian plant community diversity and turnover显示文摘 | Merritt D M Nilsson C Jansson R | 2010 | Ecological Mono- graphs2010，80，4： | 1 |
| 13 | Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study 显示文摘 | Schmidt R Launer LJ Nilsson LG | 2004 | Diabetes2004，53，3： | 1 |
| 14 | Basal glycometabolic status has an impact on long term prognosis following an acute myocardial infarction in non diabetic patients显示文摘 | Tenerz A Nilsson G Forberg R | 2003 | J Intern Med2003，254，： | 1 |
| 15 | Identification of volatile metabolltes from five fungal species cuItivatecl on two meclia显示文摘 | Sunesson A L Vaes W H J Nilsson C A Blomquist G Andersson B Carlson R | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 16 | An experimental and numerical analysis of residual strength of butt-joints panels with multiple site damage 显示文摘 | Galatolo R Nilsson K F | 2001 | Engineering Fracture Mechanics2001，，68： | 1 |
| 17 | Breaking the COPI monopoly on Golgi recycling显示文摘 | Storrie B Pepperkok R Nilsson T | 2000 | Trends Cell Biol2000，10，9： | 1 |
| 18 | A general extracorporeal immunoadsorpation method to increase tumor-normal tissue ratio in radioimmunoimaging and radioimmunotherapy显示文摘 | STRAND S-E NILSSON R | 1993 | J Nucl Med1993，34，： | 1 |
| 19 | Particle mixing and residence time when drying sawdust in a continuous spouted bed 显示文摘 | Berghel J Nilsson L Renstr~m R | 2008 | Chemical Engineering and Processing : Process Intensification2008，47，8： | 1 |
| 20 | Simultaneous extraction of di (2-ethylhexyl) phthalate and nonionic surfactants from house dust:Concentrations in floor dust from 15 Danish schools 显示文摘 | CLAUSEN P A BILLE R L L NILSSON T | 2003 | J Chromatogr A2003，986，2： | 1 |
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