|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | A regionalized IO-model to value seasonal recreational ecosystem services in a mountain National Park in Spain显示文摘Recreational Ecosystem Services(RES)are among the most frequently evaluated ecosystem services.RES are seen as a major opportunity for sustainable development in areas of high ecological value resulting from the presence of emblematic species,habitats or scenery,often integrated in conservation areas,in particular in mountain areas affected by depopulation,rising environmental risks and poverty.Economically,the assessment of RES has been based on Contingent Valuation and Choice Experiments,methods with limitations related to their subjectivity.Alternatively,Input-Output(IO)models provide a very accurate and effective way of valuation of RES with regional information regarding interindustry transactions.Whilst data on nature tourist expenditure may be only available annually,tourism inflows have a strong seasonal behavior,which impacts the profitability of several local economic activities.In this paper,we firstly constructed a novel regionalized IO-model based on Cross-Industry Location Quotients using employment data and,secondly,based on Monte Carlo simulation,we estimated nature tourist expenditure monthly using data on nature tourism inflows.This method allowed for a more precise RES evaluation,estimating direct,indirect and induced monthly economic impacts of nature-based tourism.The method was applied to the Ordesa and Monte Perdido(OMP)National Park in the Spanish Pyrenees.To estimate the average tourist expenditure,we collected and analyzed spending on commerce,hospitality and restaurants,leisure,and transport of 385 visitors.Results suggest that using a regionalized IO model leads to a considerable reduction of over-estimation of the economic impact of tourist expenditure estimated by conventional methods.Taking into consideration the direct,indirect and induced effects of tourist expenditure in 2016-2018,the total annual output effect in the OMP National Park amounted to€208.8 million,while the total income effect amounted to€86.29 million.Also,a total of 2,429 jobs were created which indicates that for each thousand annual visitors to the National Park,3.8 jobs are created in the surrounding area.Overall,the proposed methodology can be easily applied to the remaining National Parks in Spain or other regions in the world,making it a valuable tool to estimate the value of RES in areas affects by strong seasonality,to set priorities and support regional policies for mountain sustainable development. | Víctor MARTIN BARROSO Mónica de CASTRO-PARDO Pascual FERNÁNDEZ MARTÍNEZ João C.AZEVEDO | 2022 | Journal of Mountain Science2022，19，1： | 2 |
| 5 | Growth cruves for Pinus elliottii,Pinus taeda and Pinus radiata in two areas of the Calamuchita Valley显示文摘 | MóNICA D EDUARDO A GRACIELA V | 1997 | For Ecol Manage1997，95，： | 1 |
| 6 | Bioaccumulative and conehologieal assessment of heavy metal transfer in a soil - plant - snail foodchain显示文摘 | NICA D V BURA M GERGEN I | 2012 | Chem Cent J2012，6，1： | 1 |
| 7 | Incomplete processing of peroxidase transcripts in the lignin degrading fungus Phanerochaete chrysospoium显示文摘 | Macarena S Fernando L L Mónica V | 2005 | FEMS Microbiology Letters2005，242，1： | 1 |
| 8 | 法国立体定向脑电图指南显示文摘立体定向脑电图(SEEG)在上世纪60年代诞生于法国,由J.Talairach和J.Bancaud共同发明。SEEG为一种介入方法,可用于耐药性局灶癫痫,对癫痫放电在三维空间内进行实时记录,为'解剖-电关联分析'及精确外科切除提供客观依据。尽管这种方法被部分欧洲癫痫中心专家沿用长达数十年,然而,仅在近十年来才在世界范围内逐渐推广应用。在当代医疗实践中,SEEG不仅为诊断方法,也被用于治疗,如射频热凝治疗等。为达到临床上更加合理应用SEEG的目的,我们认为需要有正式指南,为此成立了特别工作组,由全法国各地大型癫痫中心(过去连续5年中每年完成SEEG超过10例)专家组成。先由工作组会议形成初步建议,然后由全体专家依据已有方法学对其进行评分。指南第一部分包括下列主题内形成框架建议:SEEG适应证与局限性;SEEG计划与实施;外科技术;电生理操作技术;SEEG解读;SEEG引导下射频热凝。指南的第二部分,由各个专家小组基于现有文献以及他们个人经验对这些议题的具体内容进一步详述。这项工作旨在向应用SEEG的癫痫中心提供了解法国专家共识的机会,尤其是那些正处在起步阶段的癫痫中心,可以作为参考蓝本。该指南的编写得到法国临床神经生理学会、国际抗癫痫联盟法国分支机构的支持。 | Isnard J Taussig D Bartolomei F Bourdillon P Catenoix H Chassoux F Chipaux M Clémenceau S Colnat-Coulbois S Denuelle M Derrey S Devaux B Dorfmüller G Gilard V Guenot M Job-Chapron AS LandréE Lebas A Maillard L McGonigal A Minotti L Montavont A Navarro V Nica A Reyns N Scholly J Sol JC Szurhaj W Trebuchon A Tyvaert L Valenti-Hirsch MP Valton L Vignal JP Sauleau P 龙绮婷 张翠荣 尚力 张玮 刘兴洲 | 2018 | 癫痫杂志2018，4，4： | 1 |
| 9 | Effect of water activity on invertase production in solid state fermentation by improved diploid strains of Aspergillus niger显示文摘 | ALBA M o NICA M G GUSTAVO V G | 2004 | Process Biochem2004，39，： | 1 |
| 10 | Space tourism: re search recommendations for the future of the industry and perspectives of potential participants显示文摘 | Reddy M V Nica M Wilkes K | | 0，，05： | 1 |
| 11 | Bioaccumulative and conchological assessment of heavy metal transfer in a soil-plant-snail food chain显示文摘 | Nica D V Bura M Gergen I | 2012 | Chem Cent J2012，6，1： | 1 |
| 12 | The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model显示文摘 | José R. Macías-Pérez Olga Beltrán-Ramírez Verónica R. Vásquez-Garzón Martha E. Salcido-Neyoy Pablo A. Martínez-Soriano Mónica B. Ruiz-Sánchez Enrique ángeles Saúl Villa-Trevi?o | 2013 | Anti-Cancer Drugs2013，，4： | 1 |
| 13 | Improving the uncommon (110) growing orientation of Al-doped ZnO thin films through sequential pulsed laser deposition 显示文摘 | COMAN T URSU E L NICA V | 2014 | Thin Solid Films2014，571，： | 1 |
| 14 | A Prospective Study on Inflammatory Parameters in Obese Patients After Sleeve Gastrectomy显示文摘 | Verónica Gumbau Marcos Bruna Enrique Canelles Marcos Guaita Claudia Mulas Carla Basés Isabel Celma Jose Puche Goitzane Marcaida Miguel Oviedo Antonio Vázquez | 2014 | Obesity Surgery2014，，6： | 1 |
| 15 | Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features显示文摘 | Edith Oregón-Romero Mónica Vázquez-Del Mercado Rosa Elena Navarro-Hernández Norma Torres-Carrillo Gloria Martínez-Bonilla Iris Estrada-García Héctor Rangel-Villalobos José Francisco Mu?oz-Valle | 2006 | Rheumatology International2006，，1： | 1 |
| 16 | Design and synthesis of germline-based hemi-humanized single-chain Fv against the CD18 surface antigen显示文摘 | Cristina C Ver nica P C V Daniel J | 2000 | Protein Engineering2000，13，5： | 1 |
| 17 | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis显示文摘 | Alberto Daniel Rocha-Mu?oz Manuel Ponce-Guarneros Jorge Ivan Gamez-Nava Eva Maria Olivas-Flores Mayra Mejía Pablo Juárez-Contreras Erika Aurora Martínez-García Esther Guadalupe Corona-Sánchez Tania Marlen Rodríguez-Hernández Mónica Vázquez-del Mercado Mar | 2015 | Journal of Immunology Research2015，，： | 1 |
| 18 | Impact of Environ-mental and Genetic Factors on Biofilm Formation by the ProbioticStrain Lactobacillus rhamnosus GG 显示文摘 | SARAH L TINE L A V MO NICA P V | 2007 | Applied and Enviromental Mi-crobiology2007，73，21： | 1 |
| 19 | Expression of granulocyte–macrophage colony stimulating factor (GM-CSF) in male germ cells: GM-CSF enhances sperm motility显示文摘 | Lourdes T. Vilanova M.Cecilia Rauch Alejandra Mansilla Angara Zambrano Mónica Brito Enrique Werner V??ctor Alfaro José F. Cox Ilona I. Concha | 2003 | Theriogenology2003，，6： | 1 |
| 20 | Microsatellite variation in maize landraces from northwestern Argentina:genetic diversity,population structure and racial affiliations显示文摘 | Verónica V L Poggio L Confalonie V A | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员