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| 1 | Review of the current targeted therapies for non-small-cell lung cancer显示文摘The last decade has witnessed the development of oncogene-directed targeted therapies that have significantly changed the treatment of non-small-cell lung cancer(NSCLC). In this paper we review the data demonstrating efficacy of gefitinib, erlotinib, and afatinib, which target the epidermal growth factor receptor(EGFR), and crizotinib which targets anaplastic lymphoma kinase(ALK). We discuss the challenge of acquired resistance to these small-molecular tyrosine kinase inhibitors and review promising agents which may overcome resistance, including the EGFR T790 Mtargeted agents CO-1686 and AZD9291, and the ALKtargeted agents ceritinib(LDK378), AP26113, alectinib(CH/RO5424802), and others. Emerging therapies directed against other driver oncogenes in NSCLC including ROS1, HER2, and BRAF are covered as well. The identification of specific molecular targets in a significant fraction of NSCLC has led to the personalized deployment of many effective targeted therapies, with more to come. | Kim-Son H Nguyen Joel W Neal Heather Wakelee | 2014 | World Journal of Clinical Oncology2014，5，4： | 13 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 4 | Arithmetic Coding for Data Compression 显示文摘 | Neal Radford M Cleary John G | 1987 | Communications of the ACM1987，30，6： | 1 |
| 5 | Arithmetic coding for data compression 显示文摘 | Witten Ian H Neal Radford M Cleary John G | 1987 | Communications of the Association for Computing Machinery1987，30，6： | 1 |
| 6 | Catchment-scale advection and dispersion as a mechanism for fractal scaling in stream tracer concentrations显示文摘 | Kirchner J W Feng X H Neal C | 2001 | Journal of hydrology2001，254，： | 1 |
| 7 | The role of the anesthesiologist in fast-track surgery:from multimodal analgesia to perioperative medical care显示文摘 | White PF Kehlet H Neal JM | | 0，，06： | 1 |
| 8 | Food Safety Regulation and Trade inFood Products显示文摘 | HOOKER NEAL H | 1999 | Food Policy1999，，24： | 1 |
| 9 | Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells 显示文摘 | Ransom CB O'Neal JT Sontheimer H | 2001 | J Neurosci2001，21，19： | 1 |
| 10 | Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances tumor response to fractionated radiotherapy显示文摘 | Mason KA Ariga H Neal R | 2005 | Clin Cancer Res2005，11，1： | 1 |
| 11 | Arithmetic Coding for Data Compression显示文摘 | Witten I H Neal R M Cleary J G | 1997 | Communications of the ACM1997，30，6： | 1 |
| 12 | Chemical Kinetics of the Oxidation of Methyl Tert-butyl Ether (MTBE)显示文摘 | Brocard J C Baronnet F O'Neal H E | 1983 | Combustion and Flame1983，52，： | 1 |
| 13 | Do aspirin andstatins prevent severe sepsis显示文摘 | Sanchez M A Thomas C B O′Neal H R | 2012 | Curr Opin Infect Dis2012，25，3： | 1 |
| 14 | Arithmetic coding for data compression 显示文摘 | Witten I H Neal R M Cleary J G | 1987 | Communications of the ACM1987，30，6： | 1 |
| 15 | Molecular prognostic markers in resectable colorectal liver metastases:a systematic review显示文摘 | Neal CP Garcea G Doucas H | 2006 | Eur J Cancer2006，42，12： | 1 |
| 16 | The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial显示文摘 | NEAL E G CHAFFE H SCHWARTZ R H | 2008 | Lancet Neurol2008，7，： | 1 |
| 17 | 显示文摘 | Zhu Jiangang Neal Bertram H | 1991 | J Appl Phys1991，9，8： | 1 |
| 18 | Retention aid polymer inter-actions with cellulosic surfaces and suspensions: a review显示文摘 | Hubbe M A Nanko H Mc Neal M R | 2009 | BioResources2009，4，2： | 1 |
| 19 | Preventable deaths due toproblems in care in English acute hospitals : a retrospective case re-cord review study显示文摘 | Hogan H Healey F Neale G | 2012 | BMJ Qual Saf2012，21，9： | 1 |
| 20 | Arithmetic coding for data compression 显示文摘 | WITTEN I H NEAL R M CLEARY J G | | Communications of the ACM0，0，6： | 1 |
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