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| 1 | Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats显示文摘AIM:To investigate whether stress-induced visceral hypersensitivity could be alleviated by electroacupuncture(EA) and whether EA effect was mediated by endogenous opiates.METHODS:Six to nine week-old male SpragueDawley rats were used in this study.Visceral hypersensitivity was induced by a 9-d heterotypic intermittent stress(HIS) protocol composed of 3 randomly stressors,which included cold restraint stress at 4?℃ for 45 min,water avoidance stress for 60 min,and forced swimming stress for 20 min,in adult male rats.The extent of visceral hypersensitivity was quantified by electromyography or by abdominal withdrawal reflex(AWR) scores of colorectal distension at different distention pressures(20 mmHg,40 mmHg,60 mmHg and 80 mmHg).AWR scores either 0,1,2,3 or 4 were obtained by a blinded observer.EA or sham EA was performed at classical acupoint ST-36(Zu-San-Li) or BL-43(Gao-Huang) in both hindlimbs of rats for 30 min.Naloxone(NLX) or NLX methiodide(m-NLX) was administered intraperitoneally to HIS rats in some experiments.RESULTS:HIS rats displayed an increased sensitivity to colorectal distention,which started from 6 h(the first measurement),maintained for 24 h,and AWR scores returned to basal levels at 48 h and 7 d after HIS compared to pre-HIS baseline at different distention pressures.The AWR scores before HIS were 0.6 ± 0.2,1.3 ± 0.2,1.9 ± 0.2 and 2.3 ± 0.2 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg distention pressures,respectively.Six hours after termination of the last stressor,the AWR scores were 2.0 ± 0.1,2.5 ± 0.1,2.8 ± 0.2 and 3.5 ± 0.2 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg distention pressures,respectively.EA given at classical acupoint ST-36 in both hindlimbs for 30 min significantly attenuated the hypersensitive responses to colorectal distention in HIS rats compared with sham EA treatment [AWRs at 20 mmHg:2.0 ± 0.2 vs 0.7 ± 0.1,P = 4.23 711 E-4;AWRs at 40 mmHg:2.6 ± 0.2 vs 1.5 ± 0.2,P = 0.00 163;AWRs at 60 mmHg:3.1 ± 0.2 vs 1.9 ± 0.1,P = 0.003;AWRs at 80 mmHg:3.6 ± 0.1 vs 2.4 ± 0.2,P = 0.0023;electromyographic(EMG) at 20 mmHg:24 ± 4.7 vs 13.8 ± 3.5;EMG at 40 mmHg:60.2 ± 6.6 vs 30 ± 4.9,P = 0.00 523;EMG at 60 mmHg:83 ± 10 vs 39.8 ± 5.9,P = 0.00 029;EMG at 80 mmHg:94.3 ± 10.8 vs 49.6 ± 5.9,P = 0.00 021].In addition,EA at the acupuncture point BL-43 with same parameters did not alleviate visceral hypersensitivity in HIS rats.EA in healthy rats also did not have any effect on AWR scores to colorectal distention at distention pressuresof 20 and 40 mmHg.The EA-mediated analgesic effect was blocked by pretreatment with NLX in HIS rats [AWR scores pretreated with NLX vs normal saline(NS) were 2.0 vs 0.70 ± 0.20,2.80 ± 0.12 vs 1.50 ± 0.27,3 vs 2.00 ± 0.15 and 3.60 ± 0.18 vs 2.60 ± 0.18 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg;P = 0.0087,0.0104,0.0117 and 0.0188 for 20,40,60 and 80 mmHg,respectively].Furthermore,EA-mediated analgesic effect was completely reversed by administration of m-NLX,a peripherally restricted opioid antagonist(EMG pretreated with m-NLX vs NS were 30.84 ± 4.39 vs 13.33 ± 3.88,74.16 ± 9.04 vs 36.28 ± 8.01,96.45 ± 11.80 vs 50.19 ± 8.28,and 111.59 ± 13.79 vs 56.42 ± 8.43 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg;P = 0.05 026,0.00 034,0.00 005,0.000 007 for 20 mmHg,40 mmHg,60 mmHg and 80 mmHg,respectively).CONCLUSION:EA given at classical acupoint ST-36 alleviates stress-induced visceral pain,which is most likely mediated by opioid pathways in the periphery. | Yuan-Yuan Zhou Natalie J Wanner Ying Xiao Xuan-Zheng Shi Xing-Hong Jiang Jian-Guo Gu Guang-Yin Xu | 2012 | World Journal of Gastroenterology2012，18，48： | 12 |
| 2 | Galvanically induced potentials to enable minimal tribochemical wear of stainless steel lubricated with sodium chloride and ionic liquid aqueous solution显示文摘The effect of galvanically induced potentials on the friction and wear behavior of a 1 RK91 stainless steel regarding to tribocorrosion was investigated using an oscillating ball-on-disk tribometer equipped with an electrochemical cell. The aim of this investigation is to develop a water-based lubricant. Therefore 1 molar sodium chloride(NaCl) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl] water solutions were used. Tribological performance at two galvanically induced potentials was compared with the non-polarized state: cathodic potential-coupling with pure aluminum- and anodic potential-coupling with pure copper. Frictional and electrochemical response was recorded during the tests. In addition, wear morphology and chemical composition of the steel were analyzed using scanning electron microscopy(SEM) and X-ray photoelectron spectroscopy(XPS), respectively. The galvanically induced cathodic polarization of the stainless steel surface results in electrochemical corrosion protection and the formation of a tribolayer. Cations from the electrolyte(sodium Na^+ and 1-ethyl- 3-methylimidazolium [C_2 mim]^+) interact and adhere on the surface. These chemical interactions lead to considerably reduced wear using 1 NaC l(86%) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl](74%) compared to the nonpolarized system. In addition, mechanical and corrosive part of wear was identified using this electrochemical technique. Therefore this method describes a promising method to develop water-based lubricants for technical applications. | Tobias AMANN Felix GATTI Natalie OBERLE Andreas KAILER Jürgen RüHE | 2018 | Friction2018，6，2： | 7 |
| 3 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 4 | Global review and synthesis of trends in observed terrestrial near-surface wind speeds: Implications for evaporation显示文摘 | Tim R. McVicar Michael L. Roderick Randall J. Donohue Ling Tao Li Thomas G. Van Niel Axel Thomas Jürgen Grieser Deepak Jhajharia Youcef Himri Natalie M. Mahowald Anna V. Mescherskaya Andries C. Kruger Shafiqur Rehman Yagob Dinpashoh | 2011 | Journal of Hydrology2011，，： | 2 |
| 5 | Development of Organizational Commitment During the First Year of Employment: A Longitudinal Study of Pre - and Post - Entry Influ- ences 显示文摘 | JOHN P MEYER D RAMONA BOBOCEL NATALIE J ALLEN | 1991 | Journal of Management1991，17，： | 1 |
| 6 | Special Issue on Productive Aging: Evidence and Opportunities for Occupational Therapy Practitioners 显示文摘 | Leland Natalie E Elliott Sharon J | 2012 | American Journal of Occupational Therapy2012，66，3： | 1 |
| 7 | Acoustic characteri- sation of the broad-scale distribution and abundance of Ant- arctic krill(Euphausia superba) off east Antarctica (30-80E)in January-march 2006显示文摘 | Toby J Natalie K Kawaguchi S | 2010 | Deep-Sea Res II2010，57，： | 1 |
| 8 | Phylogeny of Rubinceae- Rubieae inferred from the sequence of a epDNA intergene region 显示文摘 | Manen J F Natali A Ehrendorfer F | 1994 | Plant Syst Evol1994，190，： | 1 |
| 9 | Supplementation with Vitamins C and E Inhibits the Release of Interleukin -6 from Contracting Human Skeletal Muscle显示文摘 | CHRISTIAN P FISCHER NATALIE J HISCOCK | 2004 | J Physiol2004，558，2： | 1 |
| 10 | A Three-compoentConceptualization of Organizational Commitment 显示文摘 | Meyer John P Allen Natalie J | 1991 | Human Resource Management Review1991，91，1： | 1 |
| 11 | Improvements of atherosclerosis and hepatic oxidative stress are independent of exercise intensity in LDLr(-/-) mice 显示文摘 | Teodoro B G Natali A J Fernandes S A | 2012 | Atheroscler Thromb2012，19，10： | 1 |
| 12 | Supplementation with vitamins c and e inhibits the release of interleukin-6 from contracting human skeletal muscle显示文摘 | CHRISTIAN P FISCHER NATALIE J HISCOCK MILENA PENKOWA | 2004 | J Physiol2004，558，2： | 1 |
| 13 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 14 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 15 | Fractured hydrother- mal dolomite reservoirs in the Devonian Dundee Formation of the cen- tral Michigan Basin 显示文摘 | Luczaj A J Harrison I William B Natalie S W | 2006 | AAPG Bulletin2006，90，11： | 1 |
| 16 | Single-nucleotide polymorphisms in porcine mannan-binding lectin A显示文摘 | Brandon N L Natalie D K Squires E J | 2006 | Immunogenetics2006，58，12： | 1 |
| 17 | Comparison of the evolution of rbcL and atpB-rbcL noncoding spacer sequences in a recent plant group, the tribe Rubieae (Rubiaceae) 显示文摘 | Manen J F Natali A | 1995 | J Mol Evol1995，41，6： | 1 |
| 18 | Fractured hydrothermal dolomite reservoirs in the Devonian Dundee Formation of the central Michigan basin显示文摘 | Luczaj A J Harrison B W Natalie S W | 2006 | AAPG Bulletin2006，90，11： | 1 |
| 19 | One antitoxin-two functions: SR4 controls toxin mRNA decay and translation显示文摘 | NATALIE J SABINE B | 2013 | Nucleic Acids Research2013，41，21： | 1 |
| 20 | Ablation per- formance and characterization of thermoplastic polyurethane elas- tomer nanocomposites 显示文摘 | Allcorn E K Natali M Koo J H | 2013 | Composites Part A: Applied Science and Manufacturing2013，45，： | 1 |
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