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| 1 | Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations显示文摘AIM To characterize AXL receptor tyrosine kinase(AXL)expression in relationship to tumor protein P53(TP53gene,p53 protein)and its role in tumor invasion and response to therapy.METHODS We used 14 cell lines,including 3 isogenic pairs carrying mutant/knockout p53,to gain insight into the relationship between AXL and TP53.These included HCT116,HCT116.p53 mutant,RKO,and RKO.p53-/-lines(all from colon cancers)as well as breast cancer cell lines MCF7 and 1001(MCF7-p53 mutant clone).He La cell line was used as a positive control for epithelial to mesenchymal transition(EMT).AXL expression was determined by Western blotting using rabbit monoclonal antibody clone C89E7.AXL si RNA silencing was performed and followed by collagen invasion assay.Cell viability analysis using the sulforhodamine B assay and the invasion assay were performed after exposure to chemotherapeutic agents(doxorubicin for breast cancer cells;5FU or irinotecan for colon cancer cells).RESULTS We showed that the introduction of p53 mutations or knockout increased expression levels of AXL in isogenic cells compared to the matching p53 wild-type parental cells.Overall,we found a trend for correlation between the potential EMT candidate AXL,p53 alterations,and EMT markers in colorectal and breast cancers.The expression of AXL in RKO cells,a rare colon cancer cell line with inactive Wnt signaling,suggests that the AXL oncogene might provide an alternative genetic pathway for colorectal carcinogenesis in the absence of Wnt signaling activation and TP53 mutation.AXL silencing in the TP53 mutant isogenic cell lines 1001,HCT116.p53 mutant and RKO.P53-/-was>95%efficient and the silenced cells were less invasive compared to the parental TP53 wild-type cells.AXL silencing showed a subtle trend to restore colon cancer cell sensitivity to5FU or irinotecan.Importantly,AXL expressing cells developed more invasive potential after exposure to chemotherapy compared to the AXL-silenced cells.CONCLUSION AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy.These findings could have applications in cancer management. | Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair S R Aravind Maha Saber-Ayad | 2017 | World Journal of Gastroenterology2017，23，19： | 7 |
| 2 | Treatment of metastatic liver tumors using stereotactic ablative radiotherapy显示文摘The prognosis of patients with metastatic liver disease remains dismal with a median survival of only 6-12 mo. As 80%-90% of patients are not candidates for surgical therapy, there is a need for effective non-surgical therapies that would improve outcomes in these patients. The body of evidence related to the use of stereotactic ablative radiotherapy(SABR) in metastatic liver disease has substantially grown and evolved over the past decade. This review summarizes the current evidence supporting liver SABR with particular attention given to patient selection, target delineation, organ at risk dose volume constraints, response evaluation imaging and the various SABR techniques for delivering ablative radiotherapy to the liver. Even though it is unclear what dose-fractionation scheme, delivery system, concomitant therapy or patient selection strategy yields the optimum liver SABR outcomes, clear and growing evidence is available that SABR is a safe and effective therapy for the treatment of oligometastatic liver disease. | Vimoj J Nair Jason R Pantarotto | 2014 | World Journal of Radiology2014，6，2： | 2 |
| 3 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 4 | Induetian of pullulanase production in Bacillus cereus FDTA - 13 显示文摘 | NAIR S U SINGHAL R S KAMAT MY | 1998 | Bioresource Technology1998，4，： | 1 |
| 5 | Expression of a truncated Pasteurella multocida toxin antigen in Bordetella bronchiseptica显示文摘 | Rajeev S Nair R V Kania SA Bemis D A | 2003 | Vet Microbiol2003，94，4： | 1 |
| 6 | Application of k0- based INAA method in the studies of rare earth and other elements in manganese nodules from Indian Ocean 显示文摘 | Dutta K charya R Nair A G C etal | 2005 | Journal of Nuclear and Radiochemical Sciences2005，6，： | 1 |
| 7 | Benzoxazine-bismaleimide blends; Curing and thermal properties显示文摘 | Santhosh Kumar K S Reghunadhan Nair C P Sadhana R | 2007 | European Polymer Journal2007，43，12： | 1 |
| 8 | One-pot synthesis of 2,4-benzodiazepin-l-ones using benzotriazole methodology显示文摘 | Katrizky A R Nair S K | 2002 | J Org Chem2002，67，23： | 1 |
| 9 | Analysis of the influence of grinding aids on the breakage process of calcite in media mills显示文摘 | Nair P Rajendran B Paramasivam R | 1999 | Advanced Powder Technology1999，10，3： | 1 |
| 10 | Biocompatibility of b-tricalcium phosphate root replicas in porcine tooth extraction sockets-A correlative histological,ultrastructural,and Xray microanalytical pilot study显示文摘 | Nair P N R Luder H U Maspero F A | 2006 | J Biomater Appl2006，20，： | 1 |
| 11 | Benzoxazine-bisnudeimide blends: Curing and thermal properties 显示文摘 | Santhosh Kumar K S Reghunadhan Nair C P Sadhana R | 2007 | European Polymer Journal2007，43，12： | 1 |
| 12 | Splenic abscess and multiple brain abscesses caused by Streptococcus intermedius in a young healthy man 显示文摘 | Maliyil J Caire W Nair R | 2011 | Proc (Bayl Univ Med Cent)2011，24，3： | 1 |
| 13 | Study on ultrasound assisted precipitation of CL-20 and its effect on morphology and sensitivity显示文摘 | Sivabalan R Gore G M Nair U R | 2007 | Journal of Hazardous Materials2007，139，： | 1 |
| 14 | Novel Monazite Type Rare Earth Based Phosphates ARP3 Oi0 (A= Ba or Ca; R= La, Ce or Sm) Studies on Their Preparation, Structure, Microstructure and Dielectric Properties显示文摘 | Nair K R Rao P P Amina B | 2006 | Mater Lett2006，60，15： | 1 |
| 15 | Cerebral hypoxia- ischemia and middle cerebral artery occlusion induce expres- sion of the cannabinoid CB2 receptor in the brain显示文摘 | Ashton J C Rahman R M Nair S M | 2007 | Neuros- ci Lett2007，412，2： | 1 |
| 16 | Fine Structure Constant Defines Visual Transparency of Graphene显示文摘 | Nair R R Blake P Grigorenko A N | 2008 | Science2008，320，5881： | 1 |
| 17 | Integrating marker-assis- ted selection in crop breeding-prospects and challenges 显示文摘 | Babu R Nair S K Prasanna B M | 2004 | Cur- int Sci2004，87，： | 1 |
| 18 | Production of artemisinin in tissue cultures of Artemisia annua显示文摘 | Nair M S R Acton N Klayman D C | 1986 | J Nat Prod1986，49，3： | 1 |
| 19 | Antibacterial treatment strategies in hospitalized patients: What role for pharmacoeconomies?显示文摘 | GOLDMAN MP NAIR R | 2007 | Cleve Clin J Med2007，744，： | 1 |
| 20 | Temporal relation of cardiac hypertrophy, oxidative stress, and fatty acid metabolism in spontaneously hypertensive rat 显示文摘 | Purushothaman S Nair Renuka R Harikrishnan VS | 2011 | Molecular and Cellular Biochemistry2011，351，12： | 1 |
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