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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Impedance spectroscopy of porin and gramicidin pores reconstituted into supported lipid bilayers on indium-tin-oxide electrodes显示文摘 | STEFAN G PETER N FRITZ J | 1998 | Langrnuir1998，14，： | 1 |
| 3 | Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing 显示文摘 | FRITZ M A MCLACHLAN R L COHEN N L | 2003 | Fert Sterl2003，12，2： | 1 |
| 4 | Hugoniot data for iron 显示文摘 | Brown J M Fritz J N Hixson R S | 2000 | J Appl Phys2000，88，9： | 1 |
| 5 | Chronic recurrent mul-tifocal osteomyelitis:comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data显示文摘 | Fritz J Tzaribachev N Claussen CD | | 0，，03： | 1 |
| 6 | Longitudinal changes in rheumatoid arthritis after rituximab administration assessed byquantitative and dynamic contrast-enhanced 3T MR imaging: preliminary findings显示文摘 | Fritz J Galeczko EK Schwenzer N | 2009 | Eur Radiol2009，19，9： | 1 |
| 7 | Shock Compression of Tungsten and Molybdenum显示文摘 | Hixon R Fritz J N | 1992 | J Appl Phys1992，71，： | 1 |
| 8 | Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity显示文摘 | Karpuk N Burkovetskaya M Fritz T | 2011 | J Neurosci2011，31，2： | 1 |
| 9 | Overdriven-Detonation and Sound-Speed Measurements in PBX9501 and the'Thermodynamic'Chapman-Jouguet Pressure显示文摘 | Fritz J N Hixson R S Shaw M S | 1996 | J Appl Phys1996，80，11： | 1 |
| 10 | Object oriented unsteady vortex lattice method for flapping flight显示文摘 | Fritz T E Long L N | 2004 | Journal of Aircraft2004，41，6： | 1 |
| 11 | Predictive models for the median and variability of building period and damping 显示文摘 | Fritz W P Jones N P | 2009 | Journal of Structural Engineering2009，135，5： | 1 |
| 12 | Therapist on Functional Analysis and Setting Influences Outcomes 显示文摘 | Thomason - Sassi Jessica L Iwata Brian A Fritz Jennifer N | 2013 | Journal of Applied Behavior Analysis2013，，46： | 1 |
| 13 | Chronic recurrent multi- focal osteomyelitis:comparison of whole - body MR imaging with radi- ography andcorrelation with clinical and laboratory data显示文摘 | Fritz J Tzaribatchev N Claussen CD | 2009 | Radiolo- gy2009，252，3： | 1 |
| 14 | Optical technique for determining rarefaction wave velocities at very high pressures 显示文摘 | McQueen R G Hopson J W Fritz J N | 1982 | Rev Sci Instrum1982，53，2： | 1 |
| 15 | Clinical gynecologic endocrinology and infertility显示文摘 | Speroff L Fritz M Santoro N | 2006 | Obset Gynecol2006，34，5： | 1 |
| 16 | Shock compression of tungsten and molybdenum 显示文摘 | HIXSON R S FRITZ J N | 1992 | J Appl Phys1992，71，4： | 1 |
| 17 | A conceptual model of watershed response to rainfall developed through the use of oxygen-18 as a natural tracer显示文摘 | Sklash M G Farvolden R N Fritz P | 1976 | Journal of Earth Science1976，13，2： | 1 |
| 18 | Fourier transformed steady-state flash evoked potentials for continuous monitoring of visual pathway function显示文摘 | Bergholz R Lehmann T N Fritz G | | 0，，03： | 1 |
| 19 | Evaluation of potential biocontrol rhizobacteria from different host plants of VerticiUium dahliae Kleb显示文摘 | Bergl G Fritze A Roskot N | 2001 | Journal of Applied Microbiology2001，91，： | 1 |
| 20 | Survey and molecular genetics of SHV β-lactamases in Enterobacteriaceae in Switzerland : Two novel enzymes, SHV-11 and SHV-12显示文摘 | Magdalena T N Fritz H K Herbert H | 1997 | Antimicrob Agents Chemother1997，，5： | 1 |
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