|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 2 | Aloe emodin glycosidesstimulates glucose transport and glycogen storage through PI3Kdependent mechanism in L6 myotubes and inhibits adipocyte diffe-rentiation in 3T3L1 adipocytes显示文摘 | Anand S Muthusamy VS Sujatha S | 2010 | FEBS Lett2010，584，14： | 1 |
| 3 | RAF1 mutations in childhood-onset dilated cardiomyopathy 显示文摘 | Dhandapany P S Razzaque M A Muthusami U | 2014 | Nat gen2014，46，6： | 1 |
| 4 | Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition 显示文摘 | Muthusamy V S Anand S Sangeetha K N | 2008 | Chem-Biol Interact2008，174，1： | 1 |
| 5 | Leverage, growth and profitability as determinants of dividend payout ratio:evi- dence from Indian paper industry显示文摘 | JOHN S F MUTHUSAMY K | 2010 | Asian Journal of Business Management Studies2010，1，1： | 1 |
| 6 | Inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers by caffeoyl derivatives of chicory (Cichorium intybus) salad leaves 显示文摘 | Muthusamy V S Saravanababu C Ramanathan M | 2010 | BritJNutr2010，104，6： | 1 |
| 7 | Ovariecto-my induces oxidative stress and impairs bone antioxidant system in aduh rats显示文摘 | Muthusami S Ramachandran I Muthusamy B | 2005 | Clin Chim Acta2005，360，12： | 1 |
| 8 | Learning and knowledge transfer in strategic alliances: a social exchange view 显示文摘 | Muthusamy S K White M A | 2005 | Organization Studies2005，26，3： | 1 |
| 9 | Testosterone deficiency impairs glucose oxidation through defective insulin and its receptor gene expression in target tissues of adult male rats显示文摘 | Muthusamy T Dhevika S Murugesan P | | 0，，7： | 1 |
| 10 | Impact of sirolimus-eluting stent on the outcome of patients with chronic total occlusions显示文摘 | NAKAMURA S MUTHUSAMY T S BAE J H | 2005 | Am J Cardiol2005，95，： | 1 |
| 11 | Learning and knowledge transfer in strategic alliances: A social exchange view 显示文摘 | Muthusamy S K White M A | 2005 | Organization Studies2005，26，3： | 1 |
| 12 | Distributed automatic service composition in large-scale systems 显示文摘 | HU S MUTHUSAMY V LI G | 2008 | Distributed Event-based Systems2008，32，06： | 1 |
| 13 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 14 | Plasma proteome database as a resource for proteomics research 显示文摘 | Muthusamy B Hanumanthu G Suresh S | 2005 | Proteomics2005，5，： | 1 |
| 15 | Stopped-flow Fourier transform infared spectroscopy of nitromethane oxidation by the diiron (Ⅳ) intermediate of methane monooxygenase显示文摘 | Muthusamy M Ambundo E A George S J | 2003 | Journal of American Chemmical Society2003，125，11： | 1 |
| 16 | Effect of Pseudomonas fluorescens on Fusarium wilt pathogen in ba-nana rhizosphere显示文摘 | SARAVANAN S MUTHUSAMY M MARIMUTHU T | 2004 | Journal of Biological Science2004，4，2： | 1 |
| 17 | Direct coronary stent implantation:Safety,Feasibility,and predictors of success of the strategy of direct coronary stent implantation显示文摘 | Laarma G Muthusamy T S Swart H | 2000 | Catheter Cardiovasc Interv2000，52，4： | 1 |
| 18 | EGCG suppresses fused toes homolog protein through p53 in cervical cancer cells 显示文摘 | Muthusami S Prabakaran DS An Z | 2013 | Mol Biol Rep2013，40，10： | 1 |
| 19 | Learning and knowledge transfer in strategic alliances: A social exchange view 显示文摘 | Muthusamy S K White M A | 2005 | Organization Studies2005，26，3： | 1 |
| 20 | Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats显示文摘 | Muthusami S Ramachandran I Muthusamy B | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员