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35篇 您的检索式:作者名="Murillo I"
    题名 作者 年代 出处 被引量
1Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero 2007World Journal of Gastroenterology2007,13,44:4
2Transcriptional activation of a maize calcium-dependent protein kinase gene in response to fungal elicitors and infection 显示文摘Murillo I Jaeck E Cordero M J 2001Plant Mol Bio12001,45,2:1
3Transcriptional ac- tivation of a maize calcium-dependent protein kinase gene in response to fungal elicitors and infection 显示文摘Murillo I Jaeck E Cordero M J 2001Plant Mol Biol2001,45,:1
4The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases显示文摘Alfaro C Murillo O Tirapu I 2006An Sist Sanit Navar2006,29,1:1
5The maize pathogenesis-related PRms protein localizes to plasmodesmata in maize radicles显示文摘Murillo I Cavallarin L Segundo B S 1997Plant Cell1997,9,2:1
6Influence of process parameters on friction coefficient of high-chromium rolls显示文摘MORALES J SANDOVAL I MURILLO G 1999AISE Steel Technology1999,76,11:1
7Serum uricacid and outcome after acute is chemic stroke:PREMIER study显示文摘Chiquete E Ruiz Sandoval J I Murillo Bonilla L M Cerebrovasic Dis0,35,:1
8Beam energy exchange in sillenite crystals (Bi12SiO20 and Bi12TiO20),considering the variation of light modulation along sample thickness in a strong non-linear regime显示文摘L F Magana I Casar J G Murillo 2008Opt Mater2008,30,6:1
9A practical application of Katharine Kolcaba’s comfort theory to cardiac patients显示文摘Krinsky R Murillo I Johnson J 2014Appl NursRes2014,27,2:1
10Chemometrics for the resolution of co-eluting peaks of and y-tocopherols in RP- HPLC:determination in edible oils and dietary supplements显示文摘DIAZ T G CACERES M I R MURILLO B R 2007Food Chemistry2007,105,:1
11Appl Spectrosc显示文摘Berzas Nevado J J Murillo Pulgarín J A Reillo Escudero O I 200054(11):16782000,54,11:1
12Integration of a Ca looping system for CO2 capture in existing power plants显示文摘Martfnez I Murillo R Grasa G 2011Aiche Journal2011,57,9:1
13Antimycobacterial flavones from Haplopappus sonorensis显示文摘Murillo J I Encarnacion D Malmstrom J 2003Fitoterapia2003,74,:1
14Deguelin inhibits the growth of colon cancer ceils through the induction of apoptosis and cell cycle arrest 显示文摘Murillo G Sahi G I Nd K J 2002Eur J Cancer2002,38,:1
15Transcriptional activation of a maize calcium-dependent protein kinase gene in response to fungal elicitors and infection 显示文摘Murillo I Jaeck E Cordero M J 2001Plant Molecular Biology2001,45,:1
16The development of a rapid PCR assay for detection of Fusarium moniliforme 显示文摘Murillo I Cavallarin L Segundo B S 1998European Journal of Plant Pahtology1998,104,:1
17Deguelin inhibits the growth of colon cancer cells through the induction of a-potosis and cell cycle arrest显示文摘MURILLO G SALTI G I KOSMEDERJ W 2002Eur J Caneer2002,38,18:1
18Kinetics of calcination of partially carbonated particles in a Ca- looping system for CO2 capture显示文摘Martinez I Grasa G Murillo R 2012Energy & Fuels2012,26,2:1
19Multi-layered action mechanisms of CD137(4-1BB)-targeted immunotherapies显示文摘Melero I Murillo O Dubrot J Hervas-Stubbs S Perez-Gracia JL 2008Trends Pharmacol Sci2008,29,8:1
20Steam activation of tyre pyrolytic carbon black:Kinetic study in a thermobalance显示文摘Aranda A Murillo R Garc(i)a T 2007Chemical Engineering Journal2007,126,23:1
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