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| 1 | Combustion Characteristics of Swirl Coaxial Injectors at Kerosene- Rich Conditions 显示文摘 | Byung-Jik Lira Seonghyeon Seo Munki Kim | 2013 | Fuel2013，，106： | 1 |
| 2 | Flame-vortex interaction and mixing behaviors ofturbulent non-premixed jet flames under acousticforcing 显示文摘 | Kim Munki Choi Youngil Oh Jeongseog | 2009 | Combustion and Flame ^2009，156，12： | 1 |
| 3 | Flame-vortex interaction and mixing behaviors of turbulent non-premixed jet flames under acoustic forcing显示文摘 | Kim Munki Choi Youngil | 2009 | Combustion and Flame2009，156，12： | 1 |
| 4 | Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide显示文摘Temozolomide(TMZ)has been used as standard-of-care for glioblastoma multiforme(GBM),but the resistance to TMZ develops quickly and frequently.Thus,more studies are needed to elucidate the resistance mechanisms.In the current study,we investigated the relationship among the three important phenotypes,namely TMZ-resistance,cell shape and lipid metabolism,in GBM cells.We first observed the distinct difference in cell shapes between TMZ-sensitive(U87)and resistant(U87R)GBM cells.We then conducted NMR-based lipid metabolomics,which revealed a significant increase in cholesterol and fatty acid synthesis as well as lower lipid unsaturation in U87R cells.Consistent with the lipid changes,U87R cells exhibited significantly lower membrane fluidity.The transcriptomic analysis demonstrated that lipid synthesis pathways through SREBP were upregulated in U87R cells,which was confirmed at the protein level.Fatostatin,an SREBP inhibitor,and other lipid pathway inhibitors(C75,TOFA)exhibited similar or more potent inhibition on U87R cells compared to sensitive U87 cells.The lower lipid unsaturation ratio,membrane fluidity and higher fatostatin sensitivity were all recapitulated in patient-derived TMZ-resistant primary cells.The observed ternary relationship among cell shape,lipid composition,and TMZ-resistance may be applicable to other drug-resistance cases.SREBP and fatostatin are suggested as a promising target-therapeutic agent pair for drug-resistant glioblastoma. | Munki Choo Van-Hieu Mai Han Sun Kim Dong-Hwa Kim Ja-Lok Ku Sang Kook Lee Chul‐Kee Park Yong Jin An Sunghyouk Park | 2023 | Acta Pharmacologica Sinica2023，44，3： | 0 |
| 5 | Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models显示文摘Reproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal studies.Due to its physiological relevance,a swine myocardial infarction(MI)model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart diseases.Several methods are used to induce MI in the swine model.However,it is difficult,using these approaches,to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation,leading to increased experimental cost.Hence,in order to minimize human intervention,we developed an approach to use a customized occluder that has dimensional similarities with that of the coronary artery of animals in the case of the swine model.We carried out angiography to measure the diameter of the middle left anterior descending artery of each individual animal to fabricate the customized occluder using a 3D-printing system.The fabricated occluder contained a central hole smaller than that of the targeted middle left anterior descending artery to mimic an atherosclerotic coronary artery that has an approximately 20%blocked condition.Interestingly,the 3D-printed occluder can provide continuous blood flow through the central pore,indicating a high survival rate(88%)of up to 28 days post-operation.This method showed the possibility of creating consistent myocardial infarction induction as compared to the conventional representative closed-chest method(50%survival rate),thus highlighting how our method can have a profound effect on accelerating reliable experiments for developing new therapeutic approaches to ischemic heart diseases. | Han B.Kim Seungman Jung Hyukjin Park Doo S.Sim Munki Kim Sanskrita Das Youngkeun Ahn Myung H.Jeong Jinah Jang Young J.Hong | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
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