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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | The effect of bone loss on rod-like and plate like trabeculaein the cancellous bone of the mandibular condyle显示文摘 | Ruijven LJ Giesen EB Mulder L | 2005 | Bone2005，36，6： | 1 |
| 3 | Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function 显示文摘 | Osborne SE Walthers D Tomljenovic AM Mulder DT Silphaduang U Duong N Lowden MJ Wickham ME Waller RF Kenney LJ Coombes BK | 2009 | Proc Natl Acad Sci USA2009，106，10： | 1 |
| 4 | Color selection and loeationselection in ERPs: differences, similarities, and neural specificity显示文摘 | Lange JJ Wijers AA Mulder LJ | 1998 | Biological Psychology1998，48，2： | 1 |
| 5 | Preanalytical variables and off-site blood collection:influences on the results of the prothrombin time/international normalized ratio test and implications for monitoring of oral anticoagulant therapy显示文摘 | van Geest Daalderop JH Mulder AB Boonman de Winter LJ | 2005 | Int J Lab Med Mol Diag2005，51，3： | 1 |
| 6 | The effectiveness of comibined oral lysine acetylsalicyhte and metoclopramide compared with oral sumatriptan for migraine 显示文摘 | Tfelt-Hansen P Henry P Mulder LJ | 1995 | The Lancet1995，346，： | 1 |
| 7 | Preanalytical variables and off-site blood collection:influences on the results of the prothrombin time/international normalized ratio test and implications for monitoring of oral anticoagulant therapy显示文摘 | Geest-Daalderop JH Mulder AB Boonman-de Winter LJ | 2005 | Clin Chemistry2005，51，： | 1 |
| 8 | The utili ty of low frequency heart rate variability as an index of sympa- thetic cardiac tone: a review with emphasis on a reanalysis of previous studies显示文摘 | REYES DPG LANGEWITZ W MULDER LJ | 2013 | Psychophysiology2013，，50： | 1 |
| 9 | Mifepristone prevents the expression of longterm behavioural sensitization to amphetamine显示文摘 | De Vries TJ Schoffelmeer AN Tjon GH Nestby P Mulder AH Vanderschuren LJ | | 0，，02： | 1 |
| 10 | Pregnancy and marfan syndrome: an ongoing discussion显示文摘 | Mulder BJ Meijboom LJ | 2012 | J Am Coll Cardiol2012，60，3： | 1 |
| 11 | Delirium in elderly hospitalised patients:protective effects of chronic rivastigmine usage显示文摘 | Mulder LJ Olde Rikkert MG | 2004 | Int J Geriatr Psychiatry2004，19，7： | 1 |
| 12 | Stroke in a young adult with Mycoplasma pneumoniae infection complicated by intravascular coagulation 显示文摘 | Mulder LJ Spierings EL | 1987 | Neurology1987，37，8： | 1 |
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