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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma显示文摘AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February 2012.Two authors independently assessed the trials for inclusion and extracted the data.Meta-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR group.LLR was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two groups.The LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were included.Patients in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR counterpart.Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups.The LLR group appeared to have a lower incidence of postoperative ascites(OR:0.32;95%CI:0.16-0.61;P = 0.0006) as compared with OLR patients.Similarly,fewer patients had liver failure in the LLR group than in the OLR group(OR:0.15;95%CI:0.02-0.95;P =0.04).However,no significant differences were found between the two approaches with regards to operation time [WMD:4.69 min;95%CI:-22.62-32 min;P = 0.74],bile leakage(OR:0.55;95%CI:0.10-3.12;P = 0.50),postoperative bleeding(OR:0.54;95%CI:0.20-1.45;P = 0.22),pulmonary complications(OR:0.43;95%CI:0.18-1.04;P = 0.06),intra-abdominal abscesses(OR:0.21;95%CI:0.01-4.53;P = 0.32),mortality(OR:0.46;95%CI:0.14-1.51;P = 0.20),presence of positive resection margins(OR:0.59;95%CI:0.21-1.62;P = 0.31) and tumor recurrence(OR:0.95;95%CI:0.62-1.46;P = 0.81).CONCLUSION:LLR appears to be a safe and feasible option for resection of HCC in selected patients based on current evidence.However,further appropriately designed randomized controlled trials should be undertaken to ascertain these findings. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Wei Huang Rajarshi Mukherjee Gang Mai Robert Sutton Xu-Bao Liu Wei-Ming Hu | 2012 | World Journal of Gastroenterology2012，18，45： | 25 |
| 3 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 4 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 5 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 6 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 7 | A pilot study of rhuIL-11 treatment of refractory ITP 显示文摘 | Bussel J B Mukherjee R Stone A J | 2001 | Am J Hematol2001，66，3： | 1 |
| 8 | Financial regulation and securitization : evidence from subprime loans显示文摘 | KEYS B T MUKHERJEE A SERU | 2009 | Journal of Monetary Economics2009，56，： | 1 |
| 9 | Mechanical behavior and superplasticily of a severe plastic delbrmation processed nanocrystalline Ti-6AI-4V alloy显示文摘 | MISHRA R S STOLYAROV V V ECHER C VALIEV R Z MUKHERJEE A K | 2001 | Materials Science and Engineering2001，289，： | 1 |
| 10 | Some principles for designing a wide area optical network显示文摘 | Mukherjee B Banerjee D Mukherjee A | 1996 | IEEE/ACM Transactions on Networking1996，4，5： | 1 |
| 11 | Nanostructures and intermetalliccs, subjected to severe plastic deformation显示文摘 | Valiev R Z Mukherjee unique properties in A K | 2001 | Scr Mater2001，44，： | 1 |
| 12 | Common colipids,in synergy,impart high gene transfer properties to transfection incompetent cationic lipids显示文摘 | MUKHERJEE K SEN J CHAUDHURI A | 2005 | FEBS Lett2005，579，： | 1 |
| 13 | Foreign direct investment, credible policy: the role of risk sharing显示文摘 | Broll U Marjit S Mukherjee A | 2003 | The International trade Journal2003，2，： | 1 |
| 14 | Robust beamforming for security in MIMO wiretap channels with imperfect CSI 显示文摘 | Mukherjee A Swindlehurst A L | 2011 | IEEE Transactions onSignal Processing2011，59，1： | 1 |
| 15 | Disruption of sphingolipid hiosynthetic gerte IPT1 reduces Candida aIbicans adhesion and prevents activation of human gingival epithelial cell innate immune defense显示文摘 | Rouabhia M Mukherjee P K Lattif A A | 2011 | Med Mycol2011，49，5： | 1 |
| 16 | Application of liquid/sol- id fluidization technique in beneficiation of fines 显示文摘 | Mukherjee A K Mishra B K Kumar R V | 2009 | International Journal of Mineral Processing2009，92，12： | 1 |
| 17 | Pharmacological treatment of hypercortisolism显示文摘 | Shalet S Mukherjee A | | 0，，03： | 1 |
| 18 | The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults 显示文摘 | Woodhouse LJ Mukherjee A Shalet SM | 2006 | Endocr Rev2006，27，3： | 1 |
| 19 | A surface integral approach to the motion planning of nonholonomic systems 显示文摘 | Mukherjee R Anderson A | 1994 | Journal of Dynamic Systems Measurement and Control1994，116，3： | 1 |
| 20 | Diffusion weighted imaging of acute corticospinal tract injury preceding wallerian degeneration in the maturing human brain 显示文摘 | Mazumdar A Mukherjee P Miller JH | 2003 | AJNR2003，24，6： | 1 |
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