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| 1 | The Assessment of the Quality of Reporting of Meta-analyses in Diagnostic Research:a Systematic Review显示文摘 | Brian H Willis Muireann Quigley | | 0，，11： | 1 |
| 2 | An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy显示文摘 | Muireann Coen Eva M Lenz Jeremy K Nicholson | 2003 | Chem Res Toxicol2003，16，： | 1 |
| 3 | Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and alzheimer’s disease显示文摘 | Muireann Irish Olivier Piguet John R. Hodges Michael Hornberger | | Hum Brain Mapp0，，4： | 1 |
| 4 | 显示文摘 | Muireann C | 2004 | J Pharm Biomed Anal2004，35，： | 1 |
| 5 | 人类生命早期暴露组(HELIX):项目理念与设计(续完)显示文摘3.2研究2:室外暴露
传统h基于居住区评估的暴露,如室外空气污染、噪声、建筑环境,可以通过收集时间一空间活动以及(就空气污染而言)个人吸入空气量的信息,改善暴露评估和减小测量误差。例如,可替代吸入率(Kawahara等,2011)的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统(GIS)(Beelen等,2013;Eeflens等,2012)、遥感(Dadvand等,2012)和智能手机技术(deNazelle等,2013)使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。 | Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 | 2015 | 环境与职业医学2015，32，2： | 0 |
| 6 | Effect of institutional volume on laparoscopic cholecystectomy outcomes: Systematic review and metaanalysis显示文摘AIM: To determine whether institutional laparoscopy cholecystectomy(LC) volume affects rates of mortality, conversion to open surgery, bile leakage and bile duct injury(BDI).METHODS: Eligible studies were prospective or retrospective cohort studies that provided data on outcomes from consecutive LC procedures in single institutions. Relevant outcomes were mortality, conversion to open surgery, bile leakage and BDI. We performed a Medline search and extracted data. A regression analysis using generalized estimating equations were used to determine the influence of annual institutional LC caseload on outcomes. A sensitivity analysis was performed including only those studies that were published after 1995.RESULTS: Seventy-three cohorts(127404 LC procedures) were included. Average complication rates were 0.06% for mortality, 3.23% for conversion, 0.44% for bile leakage and 0.28% for bile duct injury. Annual institutional caseload did not influence rates of mortality(P = 0.142), bile leakage(P = 0.111) or bile duct injury(P = 0.198) although increasing caseload was associated with reduced incidence of conversion(P = 0.019). Results from the sensitivity analyses were similar.CONCLUSION: Institutional volume is a determinant of LC complications. It is unclear whether volume is directly linked to complication rates or whether it is an index for protocolised care. | Muireann Murray Donagh A Healy John Ferguson Khalid Bashar Seamus McHugh Mary Clarke Moloney Stewart R Walsh | 2015 | World Journal of Meta-Analysis2015，3，1： | 0 |
| 7 | Mechanistic target of rapamycin inhibitors:successes and challenges as cancer therapeutics显示文摘Delineating the contributions of specific cell signalling cascades to the development and maintenance of tumours has greatly informed our understanding of tumorigenesis and has advanced the modern era of targeted cancer therapy.It has been revealed that one of the key pathways regulating cell growth,the phosphatidylinositol 3-kinase/mechanistic target of rapamycin(PI3K/mTOR)signalling axis,is commonly dysregulated in cancer.With a specific,well-tolerated inhibitor of mTOR available,the impact of inhibiting this pathway at the level of mTOR has been tested clinically.This review highlights some of the promising results seen with mTOR inhibitors in the clinic and assesses some of the challenges that remain in predicting patient outcome following mTOR-targeted therapy. | Muireann NíBhaoighill Elaine A.Dunlop | 2019 | Cancer Drug Resistance2019，2，4： | 0 |
| 8 | 人类生命早期暴露组(HELIX):项目理念与设计(待续)显示文摘[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而'暴露组'的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画'生命早期暴露组'。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。 | Martine Vrijheid Rémy Slama Oliver Robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉 操仪 汪源 金泰廙 | 2015 | 环境与职业医学2015，32，1： | 0 |
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