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| 1 | Endoscopic retrograde cholangiopancreatography guided interventions in the management of pancreatic cancer显示文摘Pancreatic cancer is the leading cause of cancer-related morbidity and mortality with an overall five-year survival of less than 9%in the United States.At presentation,the majority of patients have painless jaundice,pruritis,and malaise,a triad that develops secondary to obstruction,which often occurs late in the course of the disease process.The technical advancements in radiological imaging and endoscopic interventions have played a crucial role in the diagnosis,staging,and management of patients with pancreatic cancer.Endoscopic retrograde cholangiopancreatography(ERCP)-guided diagnosis(with brush cytology,serial pancreatic juice aspiration cytologic examination technique,or biliary biopsy)and therapeutic interventions such as pancreatobiliary decompression,intraductal and relief of gastric outlet obstruction play a pivotal role in the management of advanced pancreatic cancer and are increasingly used due to improved morbidity and complication rates compared to surgical management.In this review,we highlight various ERCP-guided diagnostic and therapeutic interventions for the management of pancreatic cancer. | Muhammad Nadeem Yousaf Hamid Ehsan Ahsan Wahab Ahmad Muneeb Fizah S Chaudhary Richard Williams Christopher J Haas | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 3 |
| 2 | Flow of a Jeffery-Six Constant Fluid Between Coaxial Cylinders with Heat Transfer Analysis显示文摘In the present investigation we have discussed the flow of a Jeffrey-six constant incompressible fluid betweentwo infinite coaxial cylinders in the presence of heat transfer analysis.The governing equations of Jeffrey-six constant fluidalong with energy equation have been derived in cylindrical coordinates.The highly nonlinear equations are simplifiedwith the help of non-dimensional parameters and then solved analytically with the help of homotopy analysis method(HAM) for two fundamental flows namely Couette and Generalized Couette Bow.The effects of emerging parametersare discussed through graphs.The convergence of the HAM solution has been discussed by plotting h-curves. | Muhammad Yousaf Malik Azad Hussain Sohail Nadeem | 2011 | Communications in Theoretical Physics2011，56，8： | 1 |
| 3 | Role of sterile inflammation in fatty liver diseases显示文摘Sterile inflammation is a ubiquitous response of tissues to stress and injury,and occurs to a high degree in the liver.This results in high levels of tissue damage after development of the metabolic syndrome,and with alcohol excess.Inflammatory cytokines such as interleukin(IL)-1βare key in the initiation and propagation of inflammation and tissue damage.IL-1βis activated by a cytosolic machinery collectively termed the inflammasome,and by proteases released by neutrophils.Most of the inflammatory response is driven by macrophages,but hepatocytes,stellate and sinusoidal endothelial cells also have key roles.Hepatocytes for example release acute phase reactants which have pro-and anti-inflammatory effects,and are also a major source of pro-inflammatory damage associated molecules.Stellate cells can regulate differentiation of regulatory T cells by the production of transforming growth factor(TGF)βand all-trans retinoic acid,but the overall effect seems to be context dependent.The strong hepatic inflammatory response is regulated in many ways,with epigenetic regulation playing a major role.This is seen most notably with the rapid development of non-alcoholic steatohepatitis(NASH)in pups of female mice kept on a high fat diet prior to conception,but is likely occurring in adults that have been under metabolic stress for extended periods of time.Epigenetic regulation is of key importance due to its clinical implications,and potential to reveal new pathways for liver inflammation. | Yonglin Chen Muhammad Nadeem Yousaf Wajahat Z.Mehal | 2018 | Liver Research2018，2，1： | 1 |
| 4 | Angiotensin converting enzyme inhibitor associated spontaneous herniation of liver mimicking a pleural mass:A case report显示文摘BACKGROUND Spontaneous diaphragmatic herniation of the liver is a rare entity.It may mimic pulmonary mass especially in the absence of trauma.Cough is a common side effect of angiotensin converting enzyme(ACE)inhibitors that may cause diaphragmatic rupture due to a sudden increase in trans-diaphragmatic pressure.We present a case of ACE-inhibitor associated spontaneous herniation of the liver mimicking pleural mass.CASE SUMMARY An 80-year-old woman presented with dry cough for 1 mo and sudden onset of cramping abdominal pain for 1 d.She denied history of trauma,prior surgeries,smoking,alcohol or illicit drug use.She has a history of diabetes and was started on an ACE inhibitor 6 mo ago for the management of hypertension.Examination was remarkable for right upper quadrant tenderness.Lab work-up was unremarkable.Chest X-ray showed a right lower lung opacity suspecting right pleural mass.Chest computed tomography scan ruled out pleural mass,however,revealed herniated right lobe of the liver(3.9 cm×3.6 cm×3.4 cm)into the thoracic cavity through the posterolateral diaphragmatic defect.Laparoscopic repair of the diaphragmatic defect was performed and the ACE inhibitor was stopped.Patients’symptoms had completely resolved on follow-up.CONCLUSION ACE inhibitor-associated cough may cause diaphragmatic liver herniation mimicking pleural mass.Early diagnosis,surgical repair and addressing the triggering factors improve patients’outcomes. | Sameer Saleem Tebha Zain Ali Zaidi Sehrish Sethar Muhammad Asif Abbas Virk Muhammad Nadeem Yousaf | 2022 | World Journal of Hepatology2022，14，4： | 0 |
| 5 | Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic diseases.Frail and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related complications.AIM To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning Frailty.METHODS This is a cohort study using the 2018-2020 National Readmission Database.Patients aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical modification.Johns Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and non-frail.The primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to ERCP.We used univariate and multivariate regression models for analysis.RESULTS A total of 9448 patients were admitted for any indications of ERCP.Frail and non-frail patients were 3445(36.46%)and 6003(63.53%)respectively.Indications for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared to non-frail.Larger studies are warranted to investigate and mitigate modifiable risk factors. | Sanket Dhirubhai Basida Dushyant Singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Hassam Ali Sahib Singh Yash R Shah Daksh Ahluwalia Mihir Prakash Shah Saurabh Chandan Neil R Sharma Shyam Thakkar | 2024 | World Journal of Gastrointestinal Endoscopy2024，16，3： | 0 |
| 6 | Analytical Treatment of an Oldroyd 8-constant Fluid Between Coaxial Cylinders with Variable Viscosity显示文摘The flow of an Oldroyd 8-constant fluid between coaxial cylinders with variable viscosity is considered.The heat transfer analysis is also taken into account.An analytical solution of the non-linear problem is obtained usinghomotopy analysis method.The behavior of pertinent parameters is analyzed and depicted through graphs. | Muhammad Yousaf Malik Azad Hussain Sohail Nadeem | 2011 | Communications in Theoretical Physics2011，56，11： | 0 |
| 7 | Hepatotoxicity associated with Garcinia cambogia: A case report显示文摘BACKGROUND Herbal supplements(HS)for weight loss are perceived to be“safe”and“natural”,as advertised in ads,however,hepatotoxicity can be associated with consumption of some HS.Use of HS may be missed,as the patient may not report these unless specifically asked about these products,since they are often not thought of as medications with potential side effects or interaction potential.CASE SUMMARY We reported a case of a 21-year-old female with morbid obesity who presented with abdominal pain for 1 wk associated with nausea,vomiting,anorexia and myalgias.She denied smoking tobacco,drinking alcohol,usage of illicit drugs,hormonal contraceptives,or energy drinks.There was no significant past medical or family illnesses.Her laboratory workup revealed acute liver failure.The workup for possible etiologies of acute liver failure was unremarkable.She was using a weight loss herbal supplement“Garcinia cambogia”for 4 wks.This case demonstrates the association of acute liver failure with Garcinia cambogia.CONCLUSION Medical reconciliation of HS should be performed in patients with suspected acute liver failure and early discontinuation of HS can prevent further progression of drug induced hepatoxicity. | Muhammad Nadeem Yousaf Fizah S Chaudhary Seyed Mohammad Hodanazari Charmian D Sittambalam | 2019 | World Journal of Hepatology2019，11，11： | 0 |
| 8 | Cerebrospinal fluid liver pseudocyst:A bizarre long-term complication of ventriculoperitoneal shunt:A case report显示文摘BACKGROUND Ventriculoperitoneal(VP)shunt placement has become a standard of care procedure in managing hydrocephalus for drainage and absorption of cerebrospinal fluid(CSF)into the peritoneum.Abdominal pseudocysts containing CSF are the common long-term complication of this frequently performed procedure,mainly because VP shunts have significantly prolonged survival.Of these,liver CSF pseudocysts are rare entities that may cause shunt dysfunction,affect normal organ function,and therefore pose therapeutic challenges.CASE SUMMARY A 49-year-old man with history of congenital hydrocephalus status post bilateral VP shunt placement presented with progressively worsening dyspnea on exertion,abdominal discomfort/distention.Abdominal computed tomography(CT)scan revealed a large CSF pseudocyst in the right hepatic lobe with the tip of VP shunt catheter into the hepatic cyst cavity.Patient underwent robotic laparoscopic cyst fenestration with a partial hepatectomy,and repositioning of VP shunt catheter to the right lower quadrant of the abdomen.Follow-up CT demonstrated a significant reduction in hepatic CSF pseudocyst.CONCLUSION A high index of clinical suspicion is required for early detection of liver CSF pseudocysts since their presentation is often asymptomatic and cunning early in the course.Late-stage liver CSF pseudocysts could have adverse outcomes on the treatment course of hydrocephalus as well as on hepatobiliary dysfunction.There is paucity of data to define the management of liver CSF pseudocyst in current guidelines due to rare nature of this entity.The reported occurrences have been managed by laparotomy with debridement,paracentesis,radiological imaging guided fluid aspiration and laparoscopic-associated cyst fenestration.Robotic surgery is an additional minimally invasive option in the management of hepatic CSF pseudocyst;however,its use is limited by lack of widespread availability and cost of surgery. | Muhammad Nadeem Yousaf Haider A Naqvi Shriya Kane Fizah S Chaudhary Jason Hawksworth Vikram V Nayar Thomas W Faust | 2023 | World Journal of Hepatology2023，15，5： | 0 |
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