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| 1 | Gene-gene,gene-environment,gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines显示文摘Inflammation plays a significant role in the etiology of type 2 diabetes mellitus(T2DM).The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury,oxidative stress and beta cell apoptosis in T2 DM.Among the recognized markers are interleukin(IL)-6,IL-1,IL-10,IL-18,tissue necrosis factor-alpha(TNF-α),C-reactive protein,resistin,adiponectin,tissue plasminogen activator,fibrinogen and heptoglobins.Diabetes mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of inheritance.Many single nucleotide polymorphisms(SNPs) in various genes including those of pro and antiinflammatory cytokines have been reported as a risk for T2 DM.Not all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic groups.The inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene,gene-environment and gene-nutrient interactions.This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6,TNF-α,resistin and adiponectin in pathogenesis of T2 DM. | Amina Nadeem Sadaf Mumtaz Abdul Khaliq Naveed Muhammad Aslam Arif Siddiqui Ghulam Mustafa Lodhi Tausif Ahmad | 2015 | World Journal of Diabetes2015，6，4： | 4 |
| 2 | Human colon tissue in organ culture: preservation of normal and neoplastic characteristics显示文摘 | Michael K. Dame Narasimharao Bhagavathula Cohra Mankey Marissa DaSilva Tejaswi Paruchuri Muhammad Nadeem Aslam James Varani | 2010 | In Vitro Cellular & Developmental Biology - Animal2010，，2： | 1 |
| 3 | Association of Interferon-Alpha and Ribavirin-Induced Thyroid Dysfunction with Severity of Disease and Response to Treatment in Pakistani Asian Patients of Chronic Hepatitis C显示文摘 | Amina Nadeem Muhammad Aslam Alessandro Antonelli | 2012 | <journal-title>Hepatitis Research and Treatment2012，，： | 1 |
| 4 | Pomeganate as a cosmeceutieal source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells显示文摘 | Muhammad Nadeem Aslam Ephraim Philip Lansky and James Varani | 2005 | Journal of Ethnopharmacology2005，103，3： | 1 |
| 5 | Evaluation of Growth and Flowering Potential of Rosa Hybrida Culti-vars Under Faisalabad Climatic Conditions显示文摘 | MUHAMMAD NADEEM MUHAMMAD ASLAM KHAN ATIF RIAZ | 2011 | Pak J Agri Sci2011，，4： | 1 |
| 6 | 用人工神经网络混合元启发式优化技术分析不可压缩黏性流体在收敛和发散通道中的流动:一种智能方法显示文摘本文采用人工神经网络(ANN)与进化算法(特别是阿基米德优化算法(AOA)和水循环算法(WCA)相结合的方法)对非线性磁流体动力学(MHD)的Jeffery-Hamel问题,特别是收敛和发散通道中的拉伸/收缩问题进行了数值研究。这种组合技术被称为ANN-AOA-WCA。将基于复杂非线性磁流体动力学Jeffery-Hamel问题的偏微分方程转化为速度和温度的非线性常微分方程系统,我们建立了基于人工神经网络的适应度函数来求解非线性微分问题。随后,采用了一种新的AOA和WCA结合方法(AOAWCA)来优化基于神经网络的适应度函数,并确定了神经网络的最优权值和偏差。为了证明提出混合方法的有效性和多功能性,探索了一系列雷诺数、通道角和可拉伸边界值的MHD模型,从而开发了两种不同的情况。ANN-AOA-WCA的数值结果与参考解(NDSOLVE)非常接近,NDSOLVE与ANNAOA-WCA的绝对误差约为3.35×10^(−8),对可拉伸收敛和发散通道的理解特别关键。此外,为了验证ANN-AOA-WCA技术,我们对150多个独立运行进行了统计分析,以获得适应度值。 | ASLAM Muhammad Naeem RIAZ Arshad SHAUKAT Nadeem ALI Shahzad AKRAM Safia BHATTI M.M. | 2023 | Journal of Central South University2023，30，12： | 0 |
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