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| 1 | 山银花化学成分与其生物活性的研究进展(英文)显示文摘山银花作为中国传统中药,在中国有数千年历史。目前,山银花在湖南省有广泛栽培,主要作为清热药和消毒药应用。山银花主要包括咖啡酸衍生物、挥发油、黄酮类化合物、环烯醚萜苷和萜类化合物,主要有抗炎、抗肿瘤、抗氧化、抗过敏、免疫调节及抗菌活性等。本文通过查阅相关文献,对山银花的化学成分及其生物活性进行了全面的系统总结。 | 汤嫣然 曾婷 Salman zafar 袁汉文 李斌 彭彩云 王思成 翦雨青 覃艳 Muhammad Iqbal Choudhary 王炜 | 2018 | Digital Chinese Medicine2018，1，2： | 17 |
| 2 | Kadsura coccinea:A rich source of structurally diverse and biologically important compounds显示文摘Kadsura coccinea belongs to medicinally important genus Kadsura from the Schisandraceae family.It has been used in traditional Chinese medicine(TCM)for the treatment of rheumatoid arthritis and gastroenteric disorders.The initial phytochemical work focused on the identification of some structurally novel and diverse natural products,which turned the attention of many researchers towards this plant.Thus far,202 compounds have been reported in this plant.Lignans and terpenoids were found as the main chemical constituents of this plant.Some of the triterpenoids and sesquiterpenoids with novel structures are of particular interest for natural product researchers.The isolated compounds of this plant have shown different bioactivities including anti-tumor,anti-HIV,anti-inflammatory,nitric oxide(NO)production inhibitory and other pharmacological effects.This review systematically summarizes all the phytochemical and pharmacological work done so far on K.coccinea,and can be used as a reference for future research on this plant. | Yu-pei Yang Nusrat Hussain Liu Zhang Yan-zhe Jia Yu-qing Jian Bin Li Muhammad Iqbal Choudhary Atta-ur Rahman Wei Wang | 2020 | Chinese Herbal Medicines2020，12，3： | 8 |
| 3 | 南五味子属植物三萜类化合物及其药理作用研究进展(英文)显示文摘五味子科南五味子属植物在民间治疗类风湿性关节炎和胃肠疾病具有悠久历史,研究表明其主要活性成分为木脂素和三萜类化合物。三萜类化合物是五味子科五味子属和南五味子属植物的主要差异性化学成分。本文对近三十年(1987-2017年)南五味子属植物中的214种三萜类化合物的结构分类及其药理活性的研究进展进行了系统综述,以期为进一步的研究提供理论参考。 | 刘永蓓 杨玉佩 袁汉文 李明姣 邱伊星 Muhammad Iqbal CHOUDHARY 王炜 | 2018 | Digital Chinese Medicine2018，1，3： | 5 |
| 4 | 槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分(英文)显示文摘目的:研究槟榔子(Areca catechu)粗提取物中所含的抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分及其作用机制。方法:使用70%甲醇水溶液对槟榔子进行粗提取。使用生物发光血小板凝集仪在富血小板血浆中测定槟榔子粗提取物的抗血小板聚集作用,使用分光光度计在试管内测定槟榔子粗提取物对乙酰胆碱酯酶活性的抑制作用。检测槟榔子中的多种化合物以测定槟榔子中抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分。结果:槟榔子粗提取物能够抑制花生四烯酸、二磷酸腺苷、血小板活化因子、肾上腺素及钙离子载体引起的血小板聚集,尤其对二磷酸腺苷及钙离子载体引起的血小板聚集的抑制最为明显;槟榔子粗提取物能够显著抑制乙酰胆碱酯酶的活性。在所检测的槟榔子所含化合物中,只有儿茶素对肾上腺素引起的血小板聚集有显著的抑制作用,而这种抑制作用显著弱于槟榔子粗提取物,提示槟榔子中的其他成分参与了这种抑制作用;鞣酸、没食子酸、薯蓣皂苷元和异去甲槟榔次碱能够抑制乙酰胆碱酯酶的活性,其中鞣酸的抑制作用强于槟榔子粗提取物。结论:槟榔子中含有抗血小板聚集及抑制乙酰胆碱酯酶活性的有效成分,而发挥这些功效的确切成分有待进一步的研究证实。 | Muhammad Nabeel Ghayur Syed Faraz Kazim Huma Rasheed Asaad Khalid Maliha Iqbal Jumani Muhammad Iqbal Choudhary Anwarul Hassan Gilani | 2011 | 中西医结合学报2011，9，6： | 4 |
| 5 | 天然产物■酮及其苷类成分抗氧化性及其他药用价值的最新研究进展(英文)显示文摘许多植物因其新的生物活性分子的发现而受到关注。在新近被发现的几种植物化学物质中,酮表现出良好的结构多样性和药理价值。酮有多种结构,但都具有抗氧化性。因此,引起了天然产物和天然药物化学家研究兴趣。酮及其苷类化合物具有广泛的生物活性,如细胞毒性、抗炎、抗氧化、抗菌、神经保护、抗-HIV、酶抑制和降血糖等。这些分子通过清除自由基实现其药用价值。本文介绍了酮及其糖苷类成分的最新研究进展,总结了其构效关系和作用机制,旨在为酮及其类似物的进一步发现提供指导,并为其不同药物制剂的开发提供更好的思路。 | ZAFAR Salman 翦雨青 李斌 彭彩云 CHOUDHARY Muhammad Iqbal RAHMAN Atta-ur 王炜 | 2019 | Digital Chinese Medicine2019，2，3： | 2 |
| 6 | A new coumarin from Murraya paniculata显示文摘 | CHOUDHARY MUHAMMAD IQBAL AZIZUDDIN KHALID ASAAD | 2002 | Planta Medica2002，68，1： | 1 |
| 7 | Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages显示文摘Dear Editor,Quorum sensing(QS)is a widespread phenomenon in bacteria which enables them to participate in cell-to-cell communication by producing and responding to small signal molecules,thus synchronously altering their behavior depending on population density(Singh et al.,2000;Miller and Bassler,2001).Through QS,bacteria coordinate processes such as expression of virulenee factors(Slamti and Lereclus,2002),biofilm formation(Parashar et al.,2011),sporulation(Perego et al.,1996),conjugation(Kozlowicz et al.,2006),antibiotic synthesis(Miller and Bassler,2001;Whiteley et al.,2017)etc. | Xiangkai Zhen Huan Zhou Wei Ding Biao Zhou Xiaolong Xu Vanja Perculija Chun-Jung Chen Ming-Xian Chang Muhammad Iqbal Choudhary Songying Ouyang | 2019 | Protein & Cell2019，10，2： | 1 |
| 8 | Biodiesel production from microalgal isolates of southern Pakistan and quantification of FAMEs by GC-MS/MS analysis显示文摘 | Syed Ghulam Musharraf Muhammad Arif Ahmed Noureen Zehra Nurul Kabir M Iqbal Choudhary Atta-ur Rahman | 2012 | Chemistry Central Journal2012，，1： | 1 |
| 9 | Studies on the chemical constituents of Phyllanthus emblica显示文摘 | Khawaja Ansar Yasin Muhammad Aziz Choudhary Naeem Khaliq Muhammad Iqbal Choudhary Shahid Malik | 2007 | Natural Product Research2007，，9： | 1 |
| 10 | Five new peltogynoids from underground parts of Iris bungei:a Mongolian medicinal plant显示文摘 | Muhammad Iqbal Choudhary Muhammad Nur-E-Alam Farzana Akhter | 2001 | Chem Pharm Bull2001，49，10： | 1 |
| 11 | Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)显示文摘 | Luc Meva’a Mbaze Jean Alexandre Lado Jean Duplex Wansi Tze Chieh Shiao David Dako Chiozem Muhammad Ahmed Mesaik Muhammad Iqbal Choudhary Marie-Aleth Lacaille-Dubois Jean Wandji René Roy Norbert Sewald | 2009 | Phytochemistry2009，，11： | 1 |
| 12 | A benzil and isoflavone from Iris tenuifolia显示文摘 | Muhammad Iqbal Choudhary Sumaira Hareem Hina Siddiqui | 2008 | Phytochemistry2008，69，9： | 1 |
| 13 | Tsc1/Tsc2 complex: A molecular target of capsaicin for protection against testicular torsion induced injury in rats显示文摘Objective: The detailed knowledge about protective effects of capsaicin(cap) and involved mechanisms against testicular torsion(TT) is still not available completely.Methods: Male Wistar rats were assigned into four major cohorts:(i) sham,(ii) TT,(iii) three subgroups subjected to TT and different doses of cap(100, 500, and 1000 μg/mL), and(iv) three subgroups of healthy animals subjected to various concentrations of cap. The animals were decapitated at 24 h after reperfusion, and the evaluation of protein expression was performed by Western blotting assay. At 72 h after reperfusion, apoptotic cell death and tissue injury were evaluated by TUNEL nuclear and H&E staining,respectively.Results: The results showed that cap administration following TT significantly increased the expression of tuberous sclerosis proteins 1 and 2(Tsc1/Tsc2) in a dose-dependent manner(P < 0.05). Cap decreased cell apoptosis at highest dose. Likewise, cap contributed to the preservation of tubular morphology and decreased tissue injury at the highest tested concentration(1000 μg/m L).Conclusion: Collectively, our findings demonstrate the validity of cap as a therapeutic agent against TT through targeting Tsc1/Tsc2 in a dose-dependent manner. | Nasim Javdan Seyed Abdulmajid Ayatollahi Muhammad Iqbal Choudhary Safaa Al-Hasani Farzad Kobarfard Kobra Mokhtarian Majid Khoshmirsafa Athar Ata | 2019 | Chinese Herbal Medicines2019，11，2： | 1 |
| 14 | Pd(II)and Rh(III)Complexes with Isoquinoline Derivatives Induced Mitochondria-Mediated Apoptotic and Autophagic Cell Death in HepG2 Cells显示文摘Nonplatinummetal complexes of[Pd(L^(1))Cl_(2)](C1),[Rh(L^(1))Cl_(3)(DMSO)](C2),[Pd(L^(2))Cl_(2)](C3),and[Rh(L^(3))Cl_(3)(DMSO)](C4)with isoquinoline derivatives have been prepared and characterized.C1-C4 exhibited higher in vitro anticancer activity and lower toxicity than the corresponding ligands and cisplatin against HepG2 cells.The mechanistic studies revealed that C1 arrested the cell cycle at S-phase by regulation of cyclin and cyclin-dependent kinases.C1 was accumulated in mitochondria,which increased the generation of reactive oxygen species(ROS)and endoplasmic reticulum(ER)-stress response through mitochondrial dysfunction.Moreover,C1 stimulated Ca^(2+)release,activated the caspase cascade,and triggered mitochondria-mediated apoptosis.The in vivo studies of C1 demonstrated higher safety than cisplatin and effective tumor growth inhibition.C1 is a potential anticancer drug candidate. | Noor Shad Gul Taj-Malook Khan Yan-Cheng Liu Muhammad Iqbal Choudhary Zhen-Feng Chen Hong Liang | 2021 | CCS Chemistry2021，3，6： | 0 |
| 15 | Chemical and Biological Assessments of the Essential Oils of Chrysophyllum albidum G, Don显示文摘 | Fatimah Temitayo Ishola Sherifat Adeyinka Aboaba Muhammad Iqbal Choudhary Olusegun Ekundayo | 2017 | Journal of Agricultural Science and Technology(A)2017，7，4： | 0 |
| 16 | Theoretical calculations of structural, electronic, and elastic properties of CdSe_(1-x)Te_x:A first principles study显示文摘The plane wave pseudo-potential method was used to investigate the structural, electronic, and elastic properties of Cd Se_(1-x)Te_x in the zinc blende phase. It is observed that the electronic properties are improved considerably by using LDA + U as compared to the LDA approach. The calculated lattice constants and bulk moduli are also comparable to the experimental results. The cohesive energies for pure Cd Se and Cd Te binary and their mixed alloys are calculated. The second-order elastic constants are also calculated by the Lagrangian theory of elasticity. The elastic properties show that the studied material has a ductile nature. | M Shakil Muhammad Zafar Shabbir Ahmed Muhammad Raza-ur-rehman Hashmi M A Choudhary T Iqbal | 2016 | Chinese Physics B2016，25，7： | 0 |
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