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| 1 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Delayed postoperative spinal epidural hematomas显示文摘 | Uribe J Moza K Jimenez O | 2003 | Spine J2003，3，2： | 1 |
| 3 | The effect of storage temperature on histamine production and the freshness of yellowfin tuna(Tbunnus albacares)显示文摘 | Nejib G Moza A A Ismail M A | 2005 | Food Research International2005，38，2： | 1 |
| 4 | Photochemical degradation of carboxin and oxycarboxin in the presence of humic substances and soil显示文摘 | Hustert K Moza P N Kettrup A | | 0，，14： | 1 |
| 5 | The effects on the microbiological condition of product of carcass dressing, cooling, and portioning processes at a poultry packing plant 显示文摘 | Gill C O Moza L F Badoni M | 2006 | International Journal of Food Microbiology2006，110，2： | 1 |
| 6 | Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses 显示文摘 | Ricart W Lopez J Mozas J | 2009 | Epidemiol Community Health2009，63，1： | 1 |
| 7 | Photocatalytic degradation of phthalates using titanium dioxide in aqueous solution显示文摘 | Hustert K Moza P N | 1988 | Chemosphere1988，17，9： | 1 |
| 8 | Photochemistry of vinclozolin in water and methanol-water solution显示文摘 | Schick B Moza PN Hustert K | 1999 | Pestic Sci1999，55，12： | 1 |
| 9 | Photochemical degradationof carboxin and oxycarboxin in the presence of humic substances and soil显示文摘 | Hustert K Moza P N Kettrup A | 1999 | Chemosphere1999，38，14： | 1 |
| 10 | Factorial experimental design of winery wastewaters treatment by heterogeneous photo-Fenton process显示文摘 | Mosteo R Ormad P Mozas E | 2006 | Water Research2006，40，8： | 1 |
| 11 | Photohcemical degradation of carboxin and oxycarboxin in the presence of humic substances and soil 显示文摘 | K Hustert P N Moza A Kettrup | 1999 | Chemosphere1999，38，14： | 1 |
| 12 | The effect of storage temperature on histamine production and the freshness of yellowfin tuna(Thunnus albacares)显示文摘 | Nejib G Moza A A Ismail M A | 2005 | Food Research International2005，38，： | 1 |
| 13 | Delayed postoperative spinal epidural hematomas显示文摘 | Uribe J Moza K Jimenez O | 2003 | Spine J2003，3，2： | 1 |
| 14 | Characterization of mouse MyoTilin and its promoter 显示文摘 | MOLOGNI L MOZA M LALOWSKI M M | 2005 | Biochem Bioph Res Co2005，329，： | 1 |
| 15 | Delayed postoperative spinal epidural hematomas显示文摘 | Uribe J Moza K Jimenez O | 2003 | Spine J2003，3，： | 1 |
| 16 | Photokatalytischer abbau von phthalaten an titandioxid显示文摘 | Hustert K Moza P N | 1988 | Chemosphere1988，17，： | 1 |
| 17 | Delayed postoperative spinal epidural hematomas显示文摘 | UribeJ Moza K Jimenez O etal | 2003 | Spine 了2003，3，2： | 1 |
| 18 | Factors influencing retention of lanthanides ions by montmorillonite 显示文摘 | Mozas T Rodriguez A | 1980 | Clay Mineral1980，15，： | 1 |
| 19 | Delayed postoperative spinal epidural hematomas显示文摘 | Uribe J Moza K Jimenez O | 2003 | Spine J2003，3，2： | 1 |
| 20 | Delayed postoperative spinal epidural hematomas显示文摘 | Uribe J Moza K Jimenez O | 2003 | Spine J2003，3，2： | 1 |
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