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| 1 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 2 | Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis显示文摘A 69-year-old man was admitted to our hospital in October 2003,for further examination of two liver tumors.He was diagnosed with hepatocellular carcinoma(HCC) arising from decompensated hepatitis B virus(HBV)-related cirrhosis.Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC.His Child-Pugh score was 9 points at start of lamivudine treatment,improving to 5 points after 1 year.His indocyanine green at 15 min after injection test score was 48%before lamivudine treat-ment,improving to 22%after 2 years and to 5%after 4 years.Radiofrequency ablation controlled the HCC foci and maintained his liver function.In April 2009,abdominal computed tomography revealed a tumor thrombus in the right portal vein.Since his indocyanine green test results had improved to less than 10%,we performed a right hepatectomy,which was successful.To our knowledge,there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis.The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC. | Koichi Honda Masataka Seike Shin-ichiro Maehara Koichiro Tahara Hideaki Anai Akira Moriuchi Toyokichi Muro | 2012 | World Journal of Gastroenterology2012，18，20： | 7 |
| 3 | Remission of primary low-grade gastric lymphomas of the mucosa-associated lymphoid tissue type in immunocompromised pediatric patients显示文摘我们报导联系 mucosa 的淋巴组织(麦芽) 的主要胃的淋巴瘤的宽恕在二免疫打损害小儿科的病人。病人 1,在免疫的一个 14 岁的男孩损害了未知原因的状态,抱怨了重复腹的疼痛。考试与本地侵略和淋巴节点参与揭示了胃的麦芽。浆液 anti-Helicobacter pylori (H pylori ) 抗体是积极的。H pylori 根除被沉溺于它的不利效果。麦芽损害自发地在没有为淋巴瘤的任何治疗的下一 24 个月的 regressed。病人 2,一个 6 岁的男孩,为 adrenoleukodystrophy 的治疗经历了脐带血移植。他是为在移植以后的 graft-versus-host 疾病的管理抑制免疫力的药。恶心和便血出现了,进一步的考试与 H pylori 胃炎揭示了胃的麦芽。独自为 H pylori 感染由药组成的治疗根除了 H pylori 并且完全也解决了病人的麦芽损害。病人们 1 和 2 被跟随在上面在 10 年和 3 年的经期上,分别地没有恶化的任何症状。在结论, MALT 类型的胃的淋巴瘤能被保守疗法甚至在免疫治好损害小儿科的病人。 | Yasuharu Ohno Taichirou Kosaka Izumi Muraoka Takashi Kanematsu Akira Tsuru Eiichi Kinoshita Hiroyuki Moriuchi | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 4 | Comparison of cerebral activation between motor execution and motor imagery of self-feeding activity显示文摘Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt output.We aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using chopsticks.This study included 21 healthy right-handed volunteers.The self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor cortex.The mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral activation.The mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor area.Moreover,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor execution.Supplementary motor area and premotor area had important roles in the motor imagery of self-feeding activity.Moreover,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive processes.Levels of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding activity.This study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018. | Moemi Matsuo Naoki Iso Kengo Fujiwara Takefumi Moriuchi Daiki Matsuda Wataru Mitsunaga Akira Nakashima Toshio Higashi | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 5 | Prognostic Values of Matrix Metalloproteinase Family Expression in Human Colorectal Carcinoma显示文摘 | Toshimichi Asano Mitsuhiro Tada Shaoqiang Cheng Norihiro Takemoto Taro Kuramae Motoki Abe Osamu Takahashi Masaki Miyamoto Jun-Ichi Hamada Tetsuya Moriuchi Satoshi Kondo | 2008 | Journal of Surgical Research2008，，1： | 2 |
| 6 | Gene therapy targeting for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human alpha-fetoprotein promoter 显示文摘 | Ido A Uto H Moriuchi A | 2001 | Cancer Res2001，61，： | 1 |
| 7 | Fas gene mutation in the progression of adult T cell leukemia 显示文摘 | Maeda T Yamada Y Moriuchi R | 1999 | J Exp Med1999，189，7： | 1 |
| 8 | Effective treatment of experimental glioblastoma by HSV vector-mediated TNF aipha and HSV-tk gene transfer in combination with radiosurgery and ganciclovir administration显示文摘 | Niranjan A Moriuchi S Lunsford L D | 2000 | Mol Ther2000，2，2： | 1 |
| 9 | Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and Gl cyclins in rat hepatocytes显示文摘 | Moriuchi A Hirono S Ido A | 2001 | Biochem Biophys Res Commun2001，280，1： | 1 |
| 10 | In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus- 1 against leukemic B- cell malignancies (MCL, HCL, B-CLL) 显示文摘 | Misumi M Suzuki T Moriuchi S | 2003 | Leuk Res2003，27，8： | 1 |
| 11 | I kappa B-mediated apoptotic gene therapy against acute myelogenous leukemia using replication-defective HSV-1 vector expressing TK and mutant Ⅰ kappa B alpha 显示文摘 | Kuwayama Y Suzuki T Moriuchi S | 2005 | Cell Mol Biol2005，51，1： | 1 |
| 12 | Mode of action of the anti-lnfl-uenza virus activity of plant flavon01d,5,7,4-trihydroxy-8-methoxyflavone,from the roots of Scutellaria baiealensls显示文摘 | Nagai T Moriuchi R Suzuki Y | | 0，，01： | 1 |
| 13 | Synchronous Multiple Ossifying Tumors of the Digits: Metastatic Cardiac Myxoma显示文摘 | Hamade Y Moriuchi R Miyauchi T | 2016 | Circulation2016，133，6： | 1 |
| 14 | Papuloerythroderma of Ofuji associated with early gastric cancer 显示文摘 | Nomura T Kodama K Moriuchi R | 2008 | Int J Dermatol2008，47，6： | 1 |
| 15 | New drug delivery system for water-soluble drugs using silicone and its usefulness for local treat- ment:application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor 显示文摘 | Maeda M Moriuchi S Sano A | 2002 | J Control Release2002，84，12： | 1 |
| 16 | Gene therapy targeting for hepatocellular carcinoma:selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human a-fetoprotein promoter显示文摘 | Ido A Uto H Moriuchi A | 2001 | Cancer Res2001，61，7： | 1 |
| 17 | Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation显示文摘 | Takeshi Hori Kenji Nagata Satoru Hasuike Masaaki Onaga Mizue Motoda Akihiro Moriuchi Hisayoshi Iwakiri Hirofumi Uto Jyunya Kato Akio Ido Katsuhiro Hayashi Hirohito Tsubouchi | 2003 | Journal of Gastroenterology2003，，10： | 1 |
| 18 | Diverse Effects of FK506on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver显示文摘 | Moriuchi H Kamohara Y Eguchi S | 2011 | J Surg Res2011，167，1： | 1 |
| 19 | Translational research on HGF : A phase Ⅰ/Ⅱ study of recombinant human HGF for the treatment of fulminant liver failure 显示文摘 | IDO A MORIUCHI A MARUSAWA H | 2008 | Hepatology Research2008，30，1： | 1 |
| 20 | Applicability of quantitative PCR to soy processed foods containing Roundup Ready Soy显示文摘 | Moriuchi R Monma K Sagi N | 2007 | Food Control2007，18，： | 1 |
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