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| 1 | Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count显示文摘AIM:To determine the difference in clinical outcome between ulcerative colitis(UC)patients with Mayo endoscopic subscore(MES)0 and those with MES 1.METHODS:UC patients with sustained clinical remission of 6 mo or more at the time of colonoscopy were examined for clinical outcomes and the hazard ratios of clinical relapse according to MES.Parameters,including blood tests,to identify predictive factors for MES 0and slight endoscopic recurrence in clinically stablepatients were assessed.Moreover,a receiver operating characteristic curve was generated,and the area under the curve was calculated to indicate the utility of the parameters for the division between complete and partial mucosal healing.All P values were two-sided and considered significant when less than 0.05.RESULTS:A total of 183 patients with clinical remission were examined.Patients with MES 0(complete mucosal healing:n=80,44%)were much less likely to relapse than those with MES 1(partial mucosal healing:n=89,48%)(P<0.0001,log-rank test),and the hazard ratio of risk of relapse in patients with MES 1 vs MES0 was 8.17(95%CI:4.19-17.96,P<0.0001).The platelet count(PLT)<26×104/μL was an independent predictive factor for complete mucosal healing(OR=4.1,95%CI:2.15-7.99).Among patients with MES 0 at the initial colonoscopy,patients of whom colonoscopy findings shifted to MES 1 showed significant increases in PLT compared to those who maintained MES 0(3.8×104/μL vs-0.6×104/μL,P<0.0001).CONCLUSION:The relapse rate differed greatly between patients with complete and partial mucosal healing.A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT. | Asuka Nakarai Jun Kato Sakiko Hiraoka Toshihiro Inokuchi Daisuke Takei Yuki Moritou Mitsuhiro Akita Sakuma Takahashi Keisuke Hori Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，48： | 11 |
| 2 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 3 | Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene显示文摘AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of MALT1.METHODS This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were investigated.RESULTS Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1. | Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou Shunsuke Saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai Tatsuya Toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 4 | Stability of X(t) = AX(t) + BX(t- τ)显示文摘 | MORIT KOKAME H | 1989 | IEEE Trans on Automatic Control1989，34，4： | 1 |
| 5 | Cholesterol accumulates in senile plaques of Alzheimer's disease patients and in transgenic APP (SW) mice显示文摘 | MoriT Barrett C | 2001 | J Neuropathol Exp Neurol2001，60，8： | 1 |
| 6 | Novel mechanism for age-related macular degeneration : an equilibrium shift between the angiogenesis factors VEGF and PEDF 显示文摘 | Ohno-Matsui K Morit I Tombran-Tink J | 2001 | J Cell Physiol2001，189，： | 1 |
| 7 | Effects of light, temperature, gib- befell in(GA3) and their interaction on coleoptile and leaf elongation of tall, semi-dwarf and dwarf wheat显示文摘 | Moshe J Ping H S Morit Z A A | 1996 | Plant Growth Regul1996，18，： | 1 |
| 8 | Reduced retinal angiogenesis in MMP-2-deficient mice显示文摘 | Ohno-Matsui K Uetama T Yoshida T Hayano M Itoh T Morital et aJ | 2003 | Invest Ophthaimol Vis Sd2003，44，12： | 1 |
| 9 | The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis显示文摘 | Takeuchi Y Ikeda F Moritou Y | 2013 | J Gastroenterol2013，48，3： | 1 |
| 10 | Metagenomic screeningforbleomycin resistance genes 显示文摘 | Morit Mizuta S Suenagah | 2008 | App Environ Microbio2008，74，21： | 1 |
| 11 | Rrcent progress in TSH re- ceptor studies with a new concept of 'autoimm une TSH re- ceptor disease'显示文摘 | MoriT A Kam iz T Kosug is | 1994 | Endoer J1994，41，： | 1 |
| 12 | Association between aldehyde dehydro genase 2polymorphisms and the incidence of diabetic retinopatby among Japanese subjects with type 2diabetes mellitus 显示文摘 | MORITAL K SARUWATARIL J Miyagawa H | 2013 | Cardio-Vas Diabetol2013，12，132： | 1 |
| 13 | Efflux of baicalin,a flavone glucuronide of Scutellariae Radix,on Caco-2 cells through multidrug resistance-associated protein 2显示文摘 | AKAO T SAKASHITA Y SATO K MORITS M IMANAKA T | 2007 | J Pharm Pharmacol2007，59，1： | 1 |
| 14 | Reconstruction of upper limb mator function using functional electrical stimulation(FES) 显示文摘 | Morital L Keith MW Kanno T | 2007 | Acta Neurochir Suppl2007，97，： | 1 |
| 15 | CD45 opposes β-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase显示文摘 | TanJ TownT MoriT WuY Saxe M Crawford F | 2000 | JNeurosci2000，20，20： | 1 |
| 16 | CD45opposes beta–amy loid peptidin-duced microglial activation via inhibition of D44/42mitogenactivated protein kinase显示文摘 | TanJ TownT MoriT | 2000 | J Neurosci2000，20，20： | 1 |
| 17 | Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulo nephritis 显示文摘 | MasudaY ShimizuA MoriT | 2001 | Am J Pathol2001，159，2： | 1 |
| 18 | Characterization of cDNA-encoding N-terminal region ofthe quail lutropin receptor 显示文摘 | AkazomeY ParkMK MoriT | 1994 | Gen Comp Endocrinol1994，95，： | 1 |
| 19 | Volume overload results in exag-gerated cardiac hypertrophy in the atrial natriuretic peptide knockoutmouse显示文摘 | MoriT Chen YF Feng JA | 2004 | Cardiovasc Res2004，61，： | 1 |
| 20 | Current legislation gover ning clinical waste disposal显示文摘 | Morits JH | | 0，，： | 1 |
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