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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 3 | T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway显示文摘贡献体液调停 allograft 拒绝的分子的小径糟糕被定义。在这研究,我们估计了在调停抗体的 allograft 拒绝的上下文表明小径的 herpesvirus 入口 mediator/B 淋巴细胞和 T 淋巴细胞衰减器(HVEM/BTLA ) 的角色。一个试验性的背景被设计阐明 HVEM/BTLA 相互作用的封锁是否能调制感应的 de novo 在接枝拒绝的功课期间招待 antidonor 特定的抗体。测试这个假设,充分 allogeneic 专业 histocompatibility 错配建筑群的皮肤接枝被移植到与适应于不同地区生活的动物控制, anti-CD40L 或发信号的 HVEM/BTLA 的调节抗体被对待的接受者老鼠的正确胁腹上小径。 CD4 的频率 T 小囊的助手( Tfh )房间( B220 ,CD4+CXCR5+ PD-1high ), extrafollicular 助手房间( B220 ,CD4+ CXCR5 PD-1+和 PD-1 )并且幼芽的中心( GC ) B 房间(B220+Fas+GL7+)被流动 cytometry 在在接枝拒绝的尖锐阶段期间在白天 10 柱子移植排干和非排干的淋巴节点分析。适应于不同地区生活的动物特定的体液的有免疫力的反应也是的主人 antidonor 估计了。而 CD40/CD40L 小径的封锁在阻止 allogeneic 是高度有效的体液的有免疫力的反应, HVEM/BTLA-interacting 小径的调停抗体的封锁影响了 Tfh 房间的既不扩大也不 GC B 房间的扩大。因而,主机 antidonor 的功课调停抗体的反应通常继续了,没有损害开发的可检测的证据。在摘要,这些数据显示 HVEM/BTLA 相互作用为 de novo 主人 antidonor 的形成是非必需的在移植的适应于不同地区生活的动物特定的抗体。 | Jose-Ignacio Rodriguez-Barbosa Carlos Fernandez-Renedo Ana Maria Bravo Moral Leo Biihler Maria-Luisa del Rio | 2017 | Cellular & Molecular Immunology2017，14，6： | 3 |
| 4 | Ion-exclusion chromatographic determination of organic acids in vinegars显示文摘 | Lourdes Morales M Gustavo Gonzalez A Ana M Troncoso | 1998 | Journal of Chromatography A1998，822，： | 1 |
| 5 | Polyorchidism: the case in a young male and review of the literature显示文摘 | Ana Avargues Ramon Rogel Enrique Broseta Saturnino Lujan Jesus A Betancourt Gonzalo Morales Francisco Boronat | 2015 | Asian Journal of Andrology2015，17，3： | 1 |
| 6 | An approach to chemotaxonomy to the fatty acid content of some Malvaceae species 显示文摘 | Oliveira S Ana C Morals O Antonio F | 2010 | Biochemical Systematics and Ecology2010，38，5： | 1 |
| 7 | Inhibition of corneal angiogenesis by ascorbic acid in the rat model显示文摘 | Gholam A. Peyman Muhamet Kivilcim Ana Munoz Morales John T. DellaCroce Mandi D. Conway | 2007 | Graefe’s Archive for Clinical and Experimental Ophthalmology2007，，： | 1 |
| 8 | Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: Involvement of perisinusoidal stellate cells显示文摘AIM: To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis.METHODS: Using an experimental rat model of steatosis based on the intake of a hyperlipidic diet (14% fat as olive oil or sunflower oil, HL-O and HL-S, respectively), we analyzed the liver's capability of recovery after the treatment with a normal-lipidic diet (5% fat as olive oil or sunflower oil, NL-O and NL-S, respectively) by immunocytochemical and Western blot analysis of glial fibrillary acidic protein (GFAP) expression in PSCs, collagen quantification and serum aminotransferase determination.RESULTS: The fatty infiltration in the steatotic livers decreased after the treatment with both NL diets, indicating liver recovery. This decrease was accompanied with a lower collagen deposition and aminotransferase level as well as changes in the PSC population that increased the GFAP expression. The above-mentioned effects were more pronounced in animals fed on NL-O based diet. CONCLUSION: Treatment with a balanced dietenriched in olive oil contributes to the liver recovery from a stea totic process. The PSC phenotype is a marker of this hepatic-recovery model. | Raquel Hernández Esther Martínez-Lara Ana Cauelo Ma Luisa del Moral Santos Blanco Eva Siles Ana Jiménez Juan ngel Pedrosa Ma ngeles Peinado | 2005 | World Journal of Gastroenterology2005，11，47： | 1 |
| 9 | 显示文摘 | Lucilene Betega de Paiva Ana Rita Morales Thiago Ribeiro Guimaraes | 2007 | Materials Science and Engineering2007，447，： | 1 |
| 10 | Antioxidant Defenses in Fish: Biotic and Abiotic Factors显示文摘 | Rosa M. Martínez-álvarez Amalia E. Morales Ana Sanz | 2005 | Reviews in Fish Biology and Fisheries (-)2005，，1： | 1 |
| 11 | The nitrergic autonomic innervation of the liver显示文摘 | Mar??a A Peinado Mar??a L del Moral Ana Jiménez José Rodrigo Francisco J Esteban | 2002 | Autonomic Neuroscience: Basic and Clinical2002，，2： | 1 |
| 12 | Severe menopausal symptoms in middle-aged women are associated to female and male factors显示文摘 | Peter Chedraui Faustino R. Pérez-López Marcela Mendoza Bella Morales María A. Martinez Ana M. Salinas Luis Hidalgo | 2010 | Archives of Gynecology and Obstetrics2010，，5： | 1 |
| 13 | Lugar de la cirugía local en el adenocarcinoma de recto T 2 N 0 M 0显示文摘 | Xavier Serra Aracil Jordi Bombardó Juncá Laura Mora López Manuel Alcantara Moral Isidro Ayguavives Garnica Ana Darnell Marti Alex Casalots Casado Carles Pericay Pijaume Rafael Campo Fernández de Los Ríos Salvador Navarro Soto | 2008 | Cirugia Espanola2008，，2： | 1 |
| 14 | Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals显示文摘 | Hershberger RE Ana Morales A Siegfried JD | 2010 | Genet Med2010，12，11： | 1 |
| 15 | Alternative Raw Materials and Pulping Process Using Clean Technologies 显示文摘 | Jimenez L Rodriguez Alcjandro Perez A Moral Ana Serrano Luis | 2008 | Ind Crop Prod2008，28，1： | 1 |
| 16 | Cellulose nanofibers from white and naturally colored cotton fibers 显示文摘 | Eliangela de Morals Teixeira Ana Carolina Correa | 2010 | Cellulose2010，17，： | 1 |
| 17 | Exome Sequencing and Genome-Wide Linkage Analysis in 17 Families Illustrate the Complex Contribution of TTN Truncating Variants to Dilated Cardiomyopathy显示文摘 | Nadine Norton Duanxiang Li Evadnie Rampersaud Ana Morales Eden R. Martin Stephan Zuchner Shengru Guo Michael Gonzalez Dale J. Hedges Peggy D. Robertson Niklas Krumm Deborah A. Nickerson Ray E. Hershberger | 2013 | Circulation: Cardiovascular Genetics2013，，2： | 1 |
| 18 | Nickel Biosorption by Free and Immobilized Cells of Pseudomonas Fluorescens 4F39: a Comparative Study显示文摘 | SUSANA Morales ANA M Marques | 2002 | Water Air and Soil Pollution2002，135，： | 1 |
| 19 | Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats显示文摘 | Ana I. Morales César Vicente-Sánchez Mirjana Jerkic José M. Santiago Penélope D. Sánchez-González Fernando Pérez-Barriocanal José M. López-Novoa | 2005 | Toxicology and Applied Pharmacology2005，，1： | 1 |
| 20 | Effect of starvation and refeeding on digestive enzyme activities in sturgeon ( Acipenser naccarii ) and trout ( Oncorhynchus mykiss )显示文摘 | Miriam Furné Manuel García-Gallego M. Carmen Hidalgo Amalia E. Morales Alberto Domezain Julio Domezain Ana Sanz | 2008 | Comparative Biochemistry and Physiology, Part A2008，，4： | 1 |
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