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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | In vivo optical quality of posterior-chamber phakic implantable collamer lenses with a central port显示文摘Background:The aim of this review is to summarize the optical quality results in patients following the implantation of the V4c implantable collamer lens with a central port(ICL,STAAR Surgical Inc.).Main text:A literature search in several databases was carried out to identify those publications,both prospective,retrospective and/or comparative with other refractive surgery procedures,reporting optical outcomes of patients who were implanted with the V4c ICL model.A total of 17 clinical studies published between 2012 and 2021 were included in this review.A detailed analysis of the available data was performed including number of eyes,follow-up and preoperative spherical equivalent.Specifically,the review focused on several optical parameters including higher-order aberrations(HOAs),modulation transfer function(MTF)cut-off frequency and Strehl ratio.This review encompassed a total of 817 eyes measured using different optical devices based on Hartmann-Shack,retinal image quality measurement and ray-tracing technologies at different follow-ups.Conclusions:The outcomes found in this review lead us to conclude that the ICL V4c model provides good optical quality,by means of different metrics,when implanted. | Robert Montés-Micó Francisco Pastor-Pascual Enrique Artiaga-Elordi Ramón Ruiz-Mesa Pedro Tañá-Rivero | 2021 | Eye and Vision2021，8，1： | 3 |
| 3 | High-performance liquid chromatographic assay of ampicillin and its prodrug lenampicillin显示文摘 | Marzo A Mont N Ripamonti M | 1990 | JChromatogr1990，16，： | 2 |
| 4 | Cataract surgery with toric intraocular lens implantation in patients with high corneal astigmatism显示文摘 | Nienke Visser Ramón Ruíz-Mesa Francisco Pastor No?l J.C. Bauer Rudy M.M.A. Nuijts Robert Montés-Micó | 2011 | Journal of Cataract & Refractive Surgery2011，，8： | 2 |
| 5 | Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction显示文摘 | Alejandro Macchia Simona Monte Fabio Pellegrini Marilena Romero Daniel Ferrante Hernán Doval Antonio D'Ettorre Aldo Pietro Maggioni Gianni Tognoni | 2008 | European Journal of Clinical Pharmacology2008，，6： | 2 |
| 6 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 7 | Seasonal patterns ofcarbon dioxide,water vapour and energy fluxes in pin-eapple显示文摘 | JoséJ S Montes R Nikonova N | 2007 | Agricultural and Forest Meteorology2007，147，12： | 1 |
| 8 | Seasonal patterns of carbon dioxide, water vapour and energy fluxes in pineapple显示文摘 | Jos6 J S Montes R Nikonova N | 2007 | Agricultural and Forest Meteorology2007，147，12： | 1 |
| 9 | Oxygen free radicalinjury is sufficient to cause some Alzheimer-type molecularabnormalities in human CNS neuronal cells显示文摘 | de la Monte SM Ganju N Feroz N | 2000 | J Alzheimers Dis2000，2，： | 1 |
| 10 | Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations显示文摘 | Pomares X Montón C Espasa M | 2012 | Eur Respir J2012，40，2： | 1 |
| 11 | Adaptation into Spanish of the Clinically Useful Depression Outcome Scale(CUDOS)for assessing major depressive disorder from the patient’s perspective显示文摘 | Luis Auüera-Ortiz Carmen Montón Jesús Cuervo | 2013 | Actas Esp Psiquiatr2013，41，5： | 1 |
| 12 | Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease 显示文摘 | de la Monte SM Tong M Lester-Coll N | 2006 | J Alzheimers Dis2006，10，1： | 1 |
| 13 | Subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin B12 deficiency显示文摘 | Cabrerizo-Garcí JL Sebastián-Royo M Montes N | 2012 | Sao Paulo Med J2012，130，4： | 1 |
| 14 | Subacute combined spinal cord degeneration and pancytopenia secondary to se- vere vitamin B 12 deficiency显示文摘 | Cabrerizo-Garcfa JL Sebastian-Royo M Montes N | 2012 | Sao Paulo Med J2012，130，： | 1 |
| 15 | Subacute combined spinal cord degeneration and pancytopenia secondary to severe vitamin B12 deficiency显示文摘 | Cabrerizo-Garcia JL Sebastián-Royo M Montes N | | 0，，： | 1 |
| 16 | Non-symbolic arithmetic in adults and young children显示文摘 | Barth H La Mont K Lipton J Dehaene S Kanwisher N & Spelke E | | 0，，： | 1 |
| 17 | Oxygen free radical injury is sufficient to cause some Alzheimer-type molecular abnormalities in human CNS neuronal cells 显示文摘 | Monte SM Canju N Feroz N | 2000 | J Alzheimers Dis2000，2，34： | 1 |
| 18 | Leisure participation and satisfaction for healthy lifestyles 显示文摘 | MONTE R N | 2002 | Asia Life Science2002，13，2： | 1 |
| 19 | 显示文摘 | Dantas N O Qu F Y Monte A F G | 2006 | J Non-Cryst Solids2006，352，3235： | 1 |
| 20 | Printed circuit board design techniques for EMC compliance显示文摘 | Mont rose N I | 1996 | IEEE Press1996，，5： | 1 |
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