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| 1 | 人肿瘤细胞核苷酸切除修复蛋白表达与抗癌药耐药的相关性(英文)显示文摘背景与目的:核苷酸切除修复(Nucleotideexcisionrepair,NER)是真核细胞中的DNA修复多酶系统,它可能与人肿瘤细胞对抗癌药的耐药有关。本实验将探讨NER蛋白(XPA,XPB,XPD和ERCC1)的表达与人肿瘤细胞耐药的关系。方法:采用westernblot检测美国国家癌症研究所(NationalCancerInstitute,NCI)用于抗癌药筛选的60株人肿瘤细胞的ERCC1,XPA,XPBXPD表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:ERCC1,XPB和XPD的蛋白表达与抗癌药物敏感性呈负相关,在170种抗癌药物中分别有13,17和32种的耐药性与上述蛋白水平相关性显著或非常显著(P<0.05)。而XPA的表达与药物敏感性无明显正/负相关。根据已确定的6种药物作用机理分析,肿瘤细胞XPD表达与其对烷化剂类抗癌药耐药相关性显著。结论:本实验结果肿瘤细胞的XPD蛋白表达与烷化剂类抗癌药的耐药相关,提示XPD在肿瘤细胞耐药过程中起重要作用。 | 陈忠平 Areti MALAPETSA Anne MONKS Timothy G. MYERS Gérard MOHR Eaward A. SAUSVILLE Dominic A. SCUDIERO Lawrence C. PANASCI | 2002 | 癌症2002，21，3： | 12 |
| 2 | The NCI anti-cancer drug screem a smart screen to identify effec- tors of novel targets显示文摘 | MONKS A SCUDIERO D A JOHNSON G S | 1997 | Anti-Cancer Drug Des1997，12，： | 1 |
| 3 | Preditors of cognitive dysfunction after major noncardiac surgery 显示文摘 | Monk T G Weidon B C Garvan C W | 2008 | Anesthesiology2008，108，1： | 1 |
| 4 | Interpretation ot' satellite imagery of a rapidly deepening cyclones显示文摘 | Young M V Monk G A Browning K A | 1987 | Quart JRoy Meteor Soc1987，111，： | 1 |
| 5 | Predictors of cognitive dysfunction aftermajor noncardiac surgery显示文摘 | MONK T G WELDON B C GARVAN C W | | 0，，06： | 1 |
| 6 | Predictors of cognitive dysfunction after major noncardiac surgery 显示文摘 | Monk T G Weldon B C Garvan C W | 2008 | Anesthesiology2008，108，1： | 1 |
| 7 | Propofol infusion dur-ing regional anaesthesia:sedation,amnestic,and anxiolyticproperties显示文摘 | Smith I Monk T G white P F | 1994 | Anesth Analy1994，79，： | 1 |
| 8 | Pre-dictors of cognitive dysfunction after major noncardiac sur-gery显示文摘 | MONK T G WELDON B C GARVAN C W | 2008 | Anesthesiology2008，108，1： | 1 |
| 9 | Anesthetic management and one-year mortality after noncardiac surgery 显示文摘 | Monk T G Saini V Weldon B C | 2005 | Anesth Analg2005，100，1： | 1 |
| 10 | AgrD-dependent quo-rum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes 显示文摘 | Reidel C U Monk I R Casey P G | 2009 | Mol Microbiol2009，71，5： | 1 |
| 11 | Palliative radiotherapy improves pain and reduces functional interference in patients with painful bone metastases:A quality assurance study显示文摘 | Wu JS Monk G Clark T | 2006 | Clin Oncol2006，18，7： | 1 |
| 12 | Acute normovolemic hemodilution显示文摘 | MONK T G | 2005 | Anesthesiol Clin North America2005，23，2： | 1 |
| 13 | What wwill be the impact of active shareholders?A practical recipe for constructive change 显示文摘 | | 1999 | Long Range Planning1999，32，1： | 1 |
| 14 | Predictors of cognitive dysfunction after major noncardiac surgery显示文摘 | MONK T G WELDON B C GARVAN C W | 2008 | Anesthesiology2008，108，1： | 1 |
| 15 | Predictors of cognitive dysfunction after major noncardiac surgery显示文摘 | MONK T G WELDON B C GARVAN C W | 2008 | Anesthesiology2008，108，1： | 1 |
| 16 | Predictors of cognitive dysfunction after major noncardiac surgery 显示文摘 | MONK T G WELDON B C GARVAN C W | 2008 | Anesthe- siology2008，108，1： | 1 |
| 17 | Anesthetic manage- ment and one year mortality after noncardiac surgery显示文摘 | MONK T G SAINI V WELDON B C | 2005 | Anesth Analg2005，100，1： | 1 |
| 18 | Predidors of cognitive dysfunction after major noncardiac surgery显示文摘 | MONK T G WELDON B C GARVAN C W | 2008 | Anesthe- siology2008，108，1： | 1 |
| 19 | Single-step quantiFERON screening of adult contacts: a prospective cohort study of tuberculosis risk 显示文摘 | Haldar P Thuraisingam H Patel H Pereira N Free RC Entwisle J Wiselka M Hoskyns EW Monk P Barer MR Woltmann G | 2013 | Thorax2013，68，3： | 1 |
| 20 | Cerebral oxygen desaturations are associated with postoperative cognitive aysfunction in elderly patients显示文摘 | Monk G Weldon BC Weldon JE | 2002 | Anesthesiology2002，96，： | 1 |
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