| 4 | Oncolytic viruses:A novel treatment strategy for breast cancer显示文摘Breast cancer,an unceasingly occurring neoplasm,is one of the major determinants of mortality in women.Several ineffective attempts have been pursued using with conventional therapies against breast cancer.Resistance to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using viruses.Virotherapy constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor cells.Several different DNA-and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus,herpes virus,vaccinia,reovirus,Newcastle Disease virus,measles virus and vesicular stomatitis virus.This review aims to summarize the viro-therapeutical agents against breast malignancies.Key Scientific Concepts of Review:In this review paper,we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and drugs.These recombinant viruses have provided evidence of treatment efficacy against human breast cancer. | Mohammad Javanbakht Sanaz Tahmasebzadeh Luca Cegolon Nasrin Gholami Mandana Kashaki Hassan Nikoueinejad Mohamad Mozafari Mahsa Mozaffari Shi Zhao Mostafa Khafaei Morteza Izadi Saeid Fathi Reza Akhavan-Sigari | 2023 | Genes & Diseases2023，10，2： | 0 |
| 5 | Sustainable functionalization and modification of materials via multicomponent reactions in water显示文摘In materials chemistry,green chemistry has established firm ground providing essential design criteria to develop advanced tools for efficient functionalization and modification of materials.Particularly,the combination of multicomponent reactions in water and aqueous media with materials chemistry unlocks a new sustainable way for constructing multi-functionalized structures with unique features,playing significant roles in the plethora of applications.Multicomponent reactions have received significant consideration from the community of material chemistry because of their great efficiency,simple operations,intrinsic molecular diversity,and an atom and a pot economy.Also,by rational design of multicomponent reactions in water and aqueous media,the performance of some multicomponent reactions could be enhanced by the contributing“natural”form of water-soluble materials,the exclusive solvating features of water,and simple separating and recovering materials.To date,there is no exclusive review to report the sustainable functionalization and modification of materials in water.This critical review highlights the utility of various kinds of multicomponent reactions in water and aqueous media as green methods for functionalization and modification of siliceous,magnetic,and carbonaceous materials,oligosaccharides,polysaccharides,peptides,proteins,and synthetic polymers.The detailed discussion of synthetic procedures,properties,and related applicability of each functionalized/modified material is fully deliberated in this review. | Siamak Javanbakht Tahereh Nasiriani Hassan Farhid Mohammad Taghi Nazeri Ahmad Shaabani | 2022 | Frontiers of Chemical Science and Engineering2022，16，9： | 0 |
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