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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Preclinical and clinical strdies of a collagen membrane(Bio-Gide)显示文摘 | Mogler H Busch F | 1997 | Biomaterials1997，18，7： | 1 |
| 3 | Develop- ment and evaluation of a replicon particle vaccine express- ing the E2 glycoprotein of bovine viral diarrhea virus (BVDV) in cattle显示文摘 | John Dustin Loy Jill Gander Mark Mogler | 2013 | Virol J2013，10，3： | 1 |
| 4 | Scheuerle AF显示文摘 | Khoramnia R Auffarth GU Mogler C | 2013 | Ophthalmologe2013，110，1： | 1 |
| 5 | Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse显示文摘 | Kahlert C Weber H Mogler C | 2009 | Br J Cancer2009，101，3： | 1 |
| 6 | Safety, immunogenicity and efficacy of an alphavirus replicon- based swine influenza virus hemagglutinin vaccine显示文摘 | Ryan L Vander Veen Alan T Loyna than Mark A Mogler | 2012 | Vaccine2012，30，： | 1 |
| 7 | A replication-incompetent Rift Valley fever uaccine: chimeri virus-like particles protect mice and rats against lethal challenge显示文摘 | Mandell R B Koukuntla R Mogler L J | 2010 | Virology2010，397，1： | 1 |
| 8 | Annexin A2 as a differential diagnostic marker of hepatocellular tumors显示文摘 | Longerich T Haller MT Mogler C | | 0，，： | 1 |
| 9 | Association of drug transporter expression with mortality and progression- free survival in stage Ⅳ head and neck squamous cell car einoma显示文摘 | Warta R Theile D Mogler C | 2014 | PLoS One2014，9，10： | 1 |
| 10 | Development and evalua-tion of a replicon particle vaccine expressing the E2 glycoproteinof bovine viral diarrhea virus ( BVDV) in cattle显示文摘 | Loy JD Gander J Mogler M | 2013 | Virol J2013，10，3： | 1 |
| 11 | High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy显示文摘BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation therapy.Due to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor growth.Transarterial chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in LT.However,it remains unclear if one of those treatment options is superior.The analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by histopathology.AIM To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT alone.METHODS In this multicenter retrospective study,27 patients who received liver transplantation for HCC were analyzed.Patients received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver transplantation.Liver explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging therapies.Statistical analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U tests.RESULTS Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and SBRT.There were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor lesions.Strikingly,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests that a combination of TACE and SBRT increases the rate of complete histopathological response compared to TACE or SBRT alone in bridging to liver transplantation. | Ulrike Bauer Sabine Gerum Falk Roeder Stefan Münch Stephanie E Combs Alexander B Philipp Enrico N De Toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 12 | Elevated expression of c-kit in small venous malformations of blue rubber bleb nevus syndrome显示文摘 | Mogler C Beck C Kulozik A | | 0，，： | 1 |
| 13 | Safety, immunogenicity, and efficacy of an alphavirus replicon-based swine influenza virus hemagglutinin vaccine显示文摘 | Ryan L. Vander Veen Alan T. Loynachan Mark A. Mogler Brandon J. Russell D.L. Hank Harris Kurt I. Kamrud | 2012 | Vaccine2012，，11： | 1 |
| 14 | Development and evaluation of a replicon particle vaccine expressing the E2 glycoprotein of bovine viral diarrhea virus(BVDV)in cattle显示文摘 | Loy J D Gander J Mogler M | 2013 | Virol J2013，10，： | 1 |
| 15 | Increased expression of ALCAM/CD 166 in pancreatic cancer is an independent prognostic marker for poor survival and early turnout relapse显示文摘 | Kahlert C Weber H Mogler C | 2009 | Br J Cancer2009，101，3： | 1 |
| 16 | Annexin A2 as a differential diagnostic marker of hepatocellular tumors显示文摘 | Longerich T Haller MT Mogler C | 2011 | Pathol Res Pract2011，207，1： | 1 |
| 17 | Annexin A2 as a differential diagnostic marker of hepatocellular tumors显示文摘 | Longerich T Haller MT Mogler C | 2011 | Pathol Res Pract2011，207，1： | 1 |
| 18 | EIevated expression of c- kit in small venous malformations of blue rubber bleb nevus syndrome显示文摘 | Mogler C Beck C Kulozik A | 2010 | Rare Tumors2010，2，2： | 1 |
| 19 | Annexin A2as a differential diagnostic marker of hepatocellular tumors显示文摘 | Longerich T Haller MT Mogler C | 2011 | Pathol Res Pract2011，207，1： | 1 |
| 20 | Annexin A2 as a differential diagnostic marker of hepatocellular tumors显示文摘 | Longerich T Haller MT Mogler C | 2011 | Pathol Res Pract2011，207，1： | 1 |
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