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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Complete nucleotide sequence and genome organization of a chinese isolate of tobacco vein distorting virus 显示文摘 | MO X H CHEN Z B CHEN J P | 2010 | Virus Genes2010，41，3： | 1 |
| 3 | Investigation of the conductivity of asphalt concrete containing conductive fillers 显示文摘 | WU S P MO L T SHUI Z H | 2005 | Carbon2005，43，： | 1 |
| 4 | Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development显示文摘 | Mill P Mo R Fu H | 2003 | Genes & Dev2003，17，： | 1 |
| 5 | Responses of crop yield and water use efficiency to climate change in the North China Plain显示文摘 | Guo R P Lin Z H Mo X G | 2010 | Agricultural Water Management2010，97，8： | 1 |
| 6 | Investigation of the conductivity of asphalt concrete containing conductive fillers显示文摘 | Wu S P Mo L T Shui Z H | 2005 | Carbon2005，43，7： | 1 |
| 7 | Parameter bounding for time varying systems显示文摘 | NORTON J P MO S H | 1990 | Mathematics and Computers in Simulation1990，32，5： | 1 |
| 8 | Construction of an artificial bifunctional enzyme beta - galactosidase/galactose dehydrogenase, exhibiting efficient galactose channeling 显示文摘 | Ljungcrantz P Carlsson H Mansson MO | 1989 | Biochemistry1989，28，22： | 1 |
| 9 | Serum zinc, insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus显示文摘 | Bideci A Camurdan MO Cinaz P Dursun H Demirel F | 2005 | J Pediatr Endocrinol Metab2005，18，10： | 1 |
| 10 | Piezoresistivity of graphite modified asphalt-based composites 显示文摘 | WU S P MO L T SHUI Z H | 2003 | Key Engineering Materials2003，249，： | 1 |
| 11 | Combined small RNA and degradome sequencing reveals novel miRNAs and their targets in response to low nitrate availability in maize显示文摘 | Zhao Y P Xu Z H Mo Q C | 2013 | Annals of Botany2013，112，3： | 1 |
| 12 | Evaluation and identification of potential organic nematicidal volatiles from soil bacteria显示文摘 | GU Y Q MO M H ZHOU J P | 2007 | Soil Biology and Biochemistry2007，39，10： | 1 |
| 13 | Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor,a potent angiogenic mediator显示文摘 | Lappalainen H Laine P Pentikainen MO | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 14 | VHR Imagery Multi-Resolution Segmentation Based on Mean Shift显示文摘 | Mo D K Lin H Li J P | 2006 | Journal of Guangxi Normal University:Natural Science Edition2006，24，4： | 1 |
| 15 | Construction of an artificial bifunctional enzyme,beta-galactosidase/galactose dehydrogenase,exhibiting efficient galactose channeling显示文摘 | Ljungcrantz P Carlsson H Mansson MO | | 0，，22： | 1 |
| 16 | Retrofit Assessment of Window Air Conditioner 显示文摘 | Teng T P Mo H E Lin H | 2012 | Applied Thermal Engi- neering2012，32，1： | 1 |
| 17 | 显示文摘 | Wu S P Mo L T Shui Z H | 2002 | J Wuhan Univ of Tech (Mater Sci Ed)2002，17，4： | 1 |
| 18 | 显示文摘 | Wu S P Mo L T Shui Z H | 2005 | Carbon2005，43，7： | 1 |
| 19 | Can commonly-used fan driven indoor air cleaning techniques improveindoor air quality~a literature review显示文摘 | Zhang Y P Mo J H Li Y G | 2011 | AtmosphericEnvironment2011，45，26： | 1 |
| 20 | Reducing healthrisks from indoor exposures in rapidly developingurban China显示文摘 | Zhang Y P Mo J H Weschler C J | 2013 | Environmental Health Perspectives2013，121，7： | 1 |
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