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| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | The(Me:Cs)Si+eation: a stable derivative of HSi+显示文摘 | Jutzi P Mix A Rummel B | 2004 | Science2004，305，5685： | 1 |
| 3 | Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis显示文摘 | Mix Kimberlee S K S Sporn Michael B M B Brinckerhoff Constance E C E etal | 2004 | Clin OrthopRelat Res2004，427，1： | 1 |
| 4 | Partitioning beta diversity in a subtropical broad-leaved forest of China显示文摘 | LEGENDRE P MIX C REN H B | 2009 | Ecology2009，90，3： | 1 |
| 5 | Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis显示文摘 | Mix Kimberlee S K S Sporn Michael B M B Brinckerhoff Constance E C E | | 0，，427： | 1 |
| 6 | Transportation Research Record : Journal of the Transportation Research Board 显示文摘 | Mallick R B Kandhal P S Bradbury R L Asphalt Technology to Incorporate High Using Warm Mix Percentage of Re- claimed Asphalt Pavement Material in Asphalt Mixtures | 2008 | (2051):71 -792008，，2051： | 1 |
| 7 | The antidepressant and antiinflam- matory effeets of rolipram in the eentral nervous system显示文摘 | Zhu J Mix E Winblad B | 2001 | CNS Drug Rev2001，7，4： | 1 |
| 8 | fiber composites: Effect of treatment on mechanical properties 显示文摘 | COUTINHO F M B Polypropylene - wood and mixing conditions pl Polym Sci 1997 COSTA T H S CARVALHO D L | 1997 | J1997，65，6： | 1 |
| 9 | Cord blood cell therapy alters LV remodeling and cytokine expression but does not improve heart function after myocardial infarction in rats显示文摘 | Rabald S Marx G Mix B | | Cell Physiol Biochem0，21，56： | 1 |
| 10 | anguillarum显示文摘 | Zhou Y C WangJ Zhang B etal' Ultrasonic immunization of sea bream Pagrus major (Temminck & Schlegel) with a mixed vaccine against Vibrio alginolyticus and V | 2002 | Fish Diseases2002，25，6： | 1 |
| 11 | Cord blood cell therapy alters LV remodeling and cytokine expression but does not Improve heart function after myocardial infarction in rats显示文摘 | Rabald S Marx G Mix B | | 0，，5： | 1 |
| 12 | Increased dissolved terrestrial input to the coastal ocean during the last deglaciation 显示文摘 | KLINKHAMMER G P MIX A C HALEY B A | 2009 | Geochemistry Geophysics Gcosystems2009，10，： | 1 |
| 13 | Cord blood cell therapy alters LV remodeling and cytokine expression but does not improve heart function after myocardial infarction in rats显示文摘 | Rabald S Marx G Mix B | 2008 | Physiol Biochem2008，21，56： | 1 |
| 14 | Cord blood cell therapy alters LV remodeling and cytokine expression but does not improve heart function after myocardial infarction in rats显示文摘 | Rabald S Marx G Mix B | 2008 | Cell Physiol Biochem2008，21，56： | 1 |
| 15 | Surface controlled fire re- tardancy of polymers using plasma polymerisation显示文摘 | Schartel B Kuhn G Mix R | 2002 | Macro- molecular Materials and Engineering2002，287，9： | 1 |
| 16 | Status and distribution of khulan ( Equus hemionus) in Mongolia 显示文摘 | READING R P MIX H M LHAGVASUREN B | 2001 | Journal of Zoology2001，254，3： | 1 |
| 17 | Revisiting the rare earth elements in foraminiferal tests显示文摘 | Haley B A Klinkhammer G P Mix A C | 2005 | Earth Planet Sei Lett2005，239，12： | 1 |
| 18 | Randomized phase Ⅱ trial of selenomethionine as a modulator of efficacy and toxicity of chemoradiation in squamous cell carcinoma of the head and neck显示文摘AIM: To investigate whether selenomethionine(SLM) reduces mucositis incidence in patients with head and neck squamous cell cancer(HNSCC) undergoing concurrent chemoradiation(CRT).METHODS: In this multi-institutional, randomized, double-blind phase Ⅱ trial, patients with Stage Ⅲ or Ⅳ HNSCC received SLM 3600 μg/m2 or placebo twice daily for 7 d prior to CRT, once daily during CRT, and daily for 3 wk following CRT. CRT consisted of 70 Gy at 2 Gy per fraction with cisplatin 100 mg/m2 Ⅳ on days 1, 22, and 43. RESULTS: Eighteen patients were randomized, 10 received SLM, and there were no differences in baseline factors. There was no difference in mucositis or patientreported side effects between groups. There was no difference in overall or relapse-free survival at 12 mo.CONCLUSION: Addition of SLM to CRT for HNSCC was well-tolerated but did not lower the incidence of severe mucositis or improve quality of life or survival outcomes. | Michael Mix Anurag K Singh Michael Tills Shiva Dibaj Adrienne Groman Wainwright Jaggernauth Youcef Rustum Michael B Jameson | 2015 | World Journal of Clinical Oncology2015，6，5： | 0 |
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