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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | 中低收入国家的慢性病:背景、决定因素与卫生政策显示文摘近年来,中低收入国家慢性病不断上升的趋势及其产生的影响受到广泛关注,但有关这种上升趋势的解释和说明大多基于高收入国家的慢性病发展史,但其所经历的发展历程与中低收入国家并不完全相同。本文对这些差异进行评价,以更好地理解中低收入国家慢性病的流行趋势,并对慢性病决定因素的相关理论加以讨论,为慢性病的防控提供循证支持。此外,本文将慢性病防控政策看作是降低人口患病风险和个体易感性的重要干预手段,并讨论了中低收入国家需要开展的相关政策研究。在此基础上进一步强调了加强初级卫生保健改革的必要性,并将其作为降低慢性病流行趋势的一项重要政策。 | Miranda J J Kinra S Casas J P Davey Smith G Ebrahim S | 2013 | 中国卫生政策研究2013，6，10： | 2 |
| 4 | Review of research leading to new anti-herpesvirus agents in clinical development显示文摘 | Purifor DJ Beauchamp LM De Miranda P | 1993 | J Med Virol1993，，1： | 1 |
| 5 | Rheological characterization of egg yolk processed by spraydrying and lipid-cholesterol extraction with carbon dioxide显示文摘 | Miranda J Partal P Cordobes F | 2002 | Journal of the American Oil chemists society2002，79，2： | 1 |
| 6 | Preparation of conducting polyanilines doped with Keggin - type polyoxometalates and their application as counter electrode in dye - sensitized solar cells显示文摘 | ALMEIDA L GONCALVES A BENEDETTI J MIRANDA P PASSONI L NOGUEIRA A | 2010 | J Mater Sci2010，45，18： | 1 |
| 7 | Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia 显示文摘 | Baranova O Miranda LF Pichiule P | 2007 | J Neurosci2007，27，23： | 1 |
| 8 | Urethral tumor recurrence following cystectomy and urinary diversion: clinical and pathological characteries in 768 male patients 显示文摘 | STEIN JP CLARK P MIRANDA G | 2005 | J Urol2005，173，4： | 1 |
| 9 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 10 | Incorporating inventory control decisions into a strategic distribution network design model with stochastic demand 显示文摘 | Miranda P A Garrido R A | 2004 | Transportation Research Part E2004，40，： | 1 |
| 11 | Incorporating Inventory Control Decisions into a Strategic Distribution Network Design Model with Stochastic Demand 显示文摘 | Miranda P A Garrido R A | 2004 | Transportation Research Part E2004，，40： | 1 |
| 12 | Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds显示文摘 | Miranda P Pajares A Guiberteau F | | 0，，06： | 1 |
| 13 | Outbreak of human ra- bies in the Peruvian jungle 显示文摘 | Lopez A Miranda P Tejada E | 1992 | Lancet1992，339，8790： | 1 |
| 14 | Semivariogram textural classification of JERS-1(FUYO-1) SAR data obtained over a flooded area of the Amazonian rainforest显示文摘 | Miranda F P Fonseca L E N Carr J R | 2000 | International Journal of Remote Sensing2000，19，3： | 1 |
| 15 | Forme fruste of neuroleptic ma- lignant syndrome associated with the use of sertraline 显示文摘 | Miranda M Soto F Fischman P | 2011 | Parkin- sonism Relat Disord2011，17，3： | 1 |
| 16 | 9-(2- hydroxyethoxymethyl) guanine activity against viruses of the herpes group显示文摘 | Schaeffer H J Beauehamp L Miranda P de | 1978 | Nature1978，272，： | 1 |
| 17 | A Simultaneous Inventory Control and Facility Location Model with Stochastic Capacity Constraints显示文摘 | Miranda P A Garrido R A | 2006 | Networks and Spatial Economics2006，，6： | 1 |
| 18 | Chlorella vulgaris biomass used as colouring source in traditional butter cookies显示文摘 | GOUVEIA L BATISTA A P MIRANDA A | 2007 | Innovative Food Science and Emerging Technologies2007，8，3： | 1 |
| 19 | Prevalence and risk of gingival enlargement in patients treated with nifedipine显示文摘 | Miranda J Brunet L Roset P | 2001 | J Periodonto12001，72，： | 1 |
| 20 | Photochemistry of metal nitrosyl complexes,delivery of nitric oxide to biological targets显示文摘 | Ford P C Bourassa J Miranda K | 1998 | Coord Chem Rev1998，171，： | 1 |
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