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| 1 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 2 | The efficacy and safety of a single dose of polyhexamethylene biguanide gynaecologic solution versus a seven-dose regimen of vaginal clindamycin cream in patients with bacterial vaginosis显示文摘 | Minozzi M Gerli S Renzo GC | 2008 | Eur Rev Med Pharmacol Sci2008，12，1： | 1 |
| 3 | Efficacy and safety of pharmacological interventions for the treatment of the alcohol withdrawal syndrome 显示文摘 | Amato L Minozzi S Davoli M | 2011 | Cochrane Database Syst Rev2011，15，00： | 1 |
| 4 | Treatment of hirsutism with myo-inositol:a prospective clinical study显示文摘 | Minozzi M D'Andrea G Unfer V | 2008 | Reprod Biomed Online2008，17，4： | 1 |
| 5 | GM1, like IGF-I and GDNF, prevents neuronal apoptosis显示文摘 | Ferrari G Minozzi MC Zanellato AM | 1998 | Ann N Y Acad Sci1998，845，： | 1 |
| 6 | Do specialists do it better? The impact of specialization on the processes and outcomes of care for cancer patients显示文摘 | Grilli R Minozzi S Tinazzi A | | 0，，4： | 1 |
| 7 | Exercises for adolescent idio- pathic scoliosis:a Cochrane systematic review 显示文摘 | Romano M Minozzi S Zaina F | 2013 | Spine (Phila Pa 1976)2013，38，14： | 1 |
| 8 | Braces for idiopathic scoliosis in adolescents 显示文摘 | Negrini S Minozzi S Bettany-Sahikov J | 2010 | Spine2010，35，13： | 1 |
| 9 | Genome Wide Analysis of Fertility and Production Traits in Italian Holstein Cattle 显示文摘 | Minozzi G Nicolazzi E L Stella A | 2013 | PLoS ONE2013，8，80： | 1 |
| 10 | The efficacy and safety of a single dose of polyhexamethylene biguanide gynaecologic solution versus a seven-dose regimen of vaginal clindamycin cream in patients with bacterial vaginosis显示文摘 | Minozzi M Gerli S Renzo GC | 2008 | Eur Rev Med Pharmacol Sci2008，12，1： | 1 |
| 11 | Exercises for adolescent idiopathic scoliosis:a Cochrane systematic review显示文摘 | Romano M Minozzi S Zaina F | | 0，，1976： | 1 |
| 12 | The efficacy and safety of a single dose of polybexamethylene biguanide gynaecologic solution versus a seven-dose regimen of vaginal clindamycin cream in patients with bacterial vaginosis 显示文摘 | Minozzi M Gerli S Renzo GC | 2008 | Eur Rev Med Pharmacol Sci2008，12，1： | 1 |
| 13 | Anticonvulsants for alcohol withdrawal 显示文摘 | Minozzi S Amato L Vecchi S | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 14 | Anticonvulsants for alco- hol withdrawal 显示文摘 | Minozzi S Amato L Vecchi S | 2010 | Cochrane Database of Systematic Rev2010，3，00： | 1 |
| 15 | Antibody responses to keyhole limpet hemoeyanin, lipopolysaccharide,and newcastle disease virus vaccine in F2 and backcrosses of white leghorn lines selected for two different immune response traits 显示文摘 | Minozzi G Parmentier H K Nieuwland M G B | 2007 | Poult Sci2007，86，： | 1 |
| 16 | Methadone at tapered doses for the management of opioid withdrawal 显示文摘 | Amato L Davoli M Minozzi S | 2005 | Cochrane Database Syst Rev2005，，00： | 1 |
| 17 | Benzodiazepines for alcohol withdrawal显示文摘 | Amato L Minozzi S Vecchi S | 2010 | Cochrane Database Syst Rew2010，17，00： | 1 |
| 18 | PET/ CT with l~C-choline for evaluation of prostate cancer patients with biochemical recurrence: meta-analysis and critical review of available data 显示文摘 | FANTI S MINOZZI S CASTELLUCCI P | 2016 | Eur J Nucl Med Mol Imaging2016，43，1： | 1 |
| 19 | Exercises reduce the progression rate of adolescent idiopathic scoliosis: results of a comprehensive systematic review of the literature显示文摘 | Negrini S Fusco C Minozzi S | 2008 | Dis- abil Rehabil2008，30，10： | 1 |
| 20 | Physical exercise and adolescent idiopathic scoliosis: results of a comprehensive systematic review of the literature显示文摘 | Michele R Fusco C Minozzi S | 2009 | Scotiosis2009，4，1： | 1 |
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