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| 1 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 2 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 3 | Co-guiding the dendrite-free plating of lithium on lithiophilic ZnO and fluoride modified 3D porous copper for stable Li metal anode显示文摘Lithium metal battery is considered to be the most promising energy storage technologies due to its ultra-high theoretical capacity and extremely low standard potential.However,the infinite volume change during uneven deposition/dissolution process and the growth of lithium dendrite resulting in severe capacity decay and high safety hazards,which hinders the application in next generation secondary batteries.In this paper,the three dimensional(3D)porous copper is prepared through an electrochemical etching CueZn alloy,and the pore walls are modified with lithiophilic layer of ZnO and fluorine.The as-prepared 3D Cu/ZnO/F can inhibit the growth of Li dendrite and mitigate the huge volume change of Li metal anode during cycling process,resulting in stable solid electrolyte interface(SEI)layer and electrode structure.The Li|3D Cu/ZnO/F cell can be stably cycled over 300 cycles with 98% of coulomb efficiency at 0.5 mA cm^(-2),1 mAh cm^(-2).The synergistic effects of both ZnO and fluorine on inducing the uniform deposition of lithium by providing bonding sites can inhibit the generation of lithium dendrites and thus improve the electrochemical performance of lithium metal batteries. | Xinshuang Chang Hang Liu Hang Yang Jie Di Wenhao Tang Huadong Fu Mingyang Li Ruiping Liu | 2020 | Journal of Materiomics2020，6，1： | 1 |
| 4 | Stress wave tomography for the quantification of artificial hole detection in camphor trees (Cinnamomum camphora) 显示文摘 | LIN Chengjung CHANG Tuntschu JUAN Mingyang | 2011 | Taiwan J For Sci2011，26，1： | 1 |
| 5 | 小分子化合物诱导人胃上皮细胞直接转化为内胚层多潜能祖细胞显示文摘内胚层干/祖细胞是肝脏、胰腺、小肠等内脏器官的共同起源,在再生医学的基础研究和临床应用中具有广阔的应用前景。因此,寻找一种安全高效的获取内胚层干/祖细胞的方式将具有极其重要的意义。 | 王韫芳 Jinhua Qin Shuyong Wang Wencheng Zhang Jialei Duan Jing Zhang Xin Wang Fang Yan Mingyang Chang Xiaofang Liu Bo Feng Jiang Liu 裴雪涛 | 2017 | 科学新闻2017，19，4： | 0 |
| 6 | Cosmogenic^(10)Be dating of the oldest moraine in the Hengduan Mountains显示文摘The Hengduan Mountains is in the transitional zone between the Qinghai-Tibet Plateau(QTP)and the YunnanGuizhou Plateau in China,and a key area for elucidating the Quaternary environmental changes in Asia.The paleo-Daocheng ice cap was located on the Shaluli Hilly Plateau in the northeastern Hengduan Mountains,the oldest moraines in the Hengduan Mountains region were found in the ice cap area.Such glacial landforms provide key evidence to study the timing when this area entered the cryosphere with the uplift of the QTP.However,it is difficult to collect suitable glacial boulders from these moraines for traditional terrestrial in-situ cosmogenic nuclide(TCN)exposure dating because of long-term severe moraine degradation.Here,we collected clast samples from the moraine surface and depth profile to constrain the age of the oldest moraine in Kuzhaori(moraine E)using TCN^(10)Be dating technique.The minimum^(10)Be ages of five clast samples from the moraine surface range from 187.4±1.5 to 576.8±4.3 ka,implying that the moraine has been seriously degraded since deposition.Based on the TCN^(10)Be concentrations of the samples from a depth profile and simulations,the exposure-erosion-inheritance history of the profile was obtained.By fitting to the profile^(10)Be concentrations using the chi-square test,the simulations yielded a reliable age of 626.0±52.5 ka for the moraine.Therefore,the oldest moraine(moraine E)in Kuzhaori was most likely formed at about 0.63Ma ago,corresponding to the marine isotope stage(MIS)16.This glaciation represents the maximum Quaternary glaciation after the QTP was elevated into the cryosphere by the Kunlun-Yellow River Tectonic Movement. | Zhigang ZHANG Jiahong ZHENG Haitao CUI Zhijun ZHAO Xinggong KONG Chaogang ZHENG Hong ZHANG Fei GUO Zhiyang CHANG Xue YUAN Mingyang YAN Jie ZHANG Jian WANG | 2023 | Science China Earth Sciences2023，66，10： | 0 |
| 7 | Programmable Metasurface for Simultaneously Wireless Information and Power Transfer System显示文摘Implementing self-sustainable wireless communication systems is urgent and challenging for 5G and 6G technologies.In this paper,we elaborate on a system solution using the programmable metasurface(PMS)for simultaneous wireless information and power transfers(SWIPT),offering an optimized wireless energy management network.Both transmitting and receiving sides of the proposed solution are presented in detail.On the transmitting side,employing the wireless power transfer(WPT)technique,we present versatile power conveying strategies for near-field or far-field targets,single or multiple targets,and equal or unequal power targets.On the receiving side,utilizing the wireless energy harvesting(WEH)technique,we report our work on multi-functional rectifying metasurfaces that collect the wirelessly transmitted energy and the ambient energy.More importantly,a numerical model based on the plane-wave angular spectrum method is investigated to accurately calculate the radiation fields of PMS in the Fresnel and Fraunhofer regions.With this model,the efficiencies of WPT between the transmitter and the receiver are analyzed.Finally,future research directions are discussed,and integrated PMS for wireless information and wireless power is outlined. | CHANG Mingyang HAN Jiaqi MA Xiangjin XUE Hao WU Xiaonan LI Long CUI Tiejun | 2022 | ZTE Communications2022，20，2： | 0 |
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