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| 1 | A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice,rabbits and NHPs显示文摘The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines.Here,we discovered a new STING agonist,CF501,and found that CF501-adjuvanted RBD-FC vaccine(CF501/RBD-FC)elicited significantly stronger neutralizing antibody(nAb)and T cell responses than Alum-and cGAMP-adjuvanted RBD-FC in mice.Vaccination of rabbits and rhesus macaques(nonhuman primates,NHPs)with CF501/RBD-FC elicited exceptionally potent nAb responses against SARS-CoV-2 and its nine variants and 41 S-mutants,SARS-CoV and bat SARSr-CoVs.CF501/RBD-FC-immunized hACE2-transgenic mice were almost completely protected against SARS-CoV-2 challenge,even 6 months after the initial immunization.NHPs immunized with a single dose of CF501/RBD-FC produced high titers of nAbs.The immunized macaques also exhibited durable humoral and cellular immune responses and showed remarkably reduced viral load in the upper and lower airways upon SARS-CoV-2 challenge even at 108 days post the final immunization.Thus,CF501/RBD-Fc can be further developed as a novel pan-sarbecovirus vaccine to combat current and future outbreaks of sarbecovirus diseases. | Zezhong Liu Jie Zhou Wei Xu Wei Deng Yanqun Wang Meiyu Wang Qian Wang Ming Hsieh Jingming Dong Xinling Wang Weijin Huang Lixiao Xing Miaoling He Chunlin Tao Youhua Xie Yilong Zhang Youchun Wang Jincun Zhao Zhenghong Yuan Chuan Qin Shibo Jiang Lu Lu | 2022 | Cell Research2022，32，3： | 5 |
| 2 | H elicobacter pylori infection associated with high H b A 1c and type 2 diabetes显示文摘 | Ming‐Chia Hsieh Sophie S. W. Wang Yi‐Ting Hsieh Fu‐Chen Kuo Maw‐Soan Soon Deng‐Chyang Wu | 2013 | Eur J Clin Invest2013，，9： | 4 |
| 3 | The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension显示文摘 | Jen‐Chen Tsai Hung‐Yu Yang Wei‐Hsin Wang Ming‐Hsiung Hsieh Pei‐Ti Chen Ching‐Chiu Kao Pai‐Feng Kao Chia‐Hui Wang Paul Chan | 2004 | Clinical and Experimental Hypertension2004，，3： | 2 |
| 4 | Characterization and distribution of metals in surficial sediments in South-western Taiwan 显示文摘 | Lee Chon Lin Fang Meng Der Hsieh Ming Tsuen | 1998 | Mar Pollut Bull1998，36，6： | 1 |
| 5 | A novel prediction-based strategy for object tracking in sensor networks by mining seamless temporal movement patterns 显示文摘 | Lin K W Hsieh Ming Hua Tseng V S | 2010 | Expert Systems with Applications2010，37，： | 1 |
| 6 | Three-dimen-sional microstructured tissue scaffolds fabricated bytwo-photon laser scanning photolithography显示文摘 | TSENG Ming Hsieh CHIEN Wei Benjamin Ng KARTHIKEYAN Narayanan | 2010 | Bio-materials2010，31，30： | 1 |
| 7 | The haemag- glutinin of Avibaeterium paragallinarum is a trimeric auto- transporter adhesin that confers haemagglutination,ceil adher- ence and biofilm formation activities 显示文摘 | Wang Yi Ping Hsieh Ming Kun Tan Duen Huey | 2014 | Vet Microbiol2014，174，13： | 1 |
| 8 | Preparation, characterization and electrochemical corrosion studies on environmentally friendly waterborne polyurethane/Na^+ -MMT clay nanocomposite coatings 显示文摘 | Jui Ming Yeh Chia Tseng Yao Chi Fa Hsieh | 2008 | European Polymer Journal2008，44，10： | 1 |
| 9 | Preparation and properties of amino-terminated anionic waterbornepolyurethane-silica hybrid materials through a sol-gel process in the absence of an external catalyst 显示文摘 | Jui Ming Yeh Chia Tseng Yao Chi Fa Hsieh | 2008 | European Polymer Journal2008，44，9： | 1 |
| 10 | Identifying Brand Image Dimensionality and Measuring the Degree of Brand Globalization: A Cross-National Study 显示文摘 | Hsieh Ming H | 2002 | Joumal of International Marketing2002，10，2： | 1 |
| 11 | Higher frequency of apolipoprotein E2 allele in type 2 diabetic patients with nephropathy in Taiwan 显示文摘 | Ming - Chia Hsieh Shiu - Ru Lin Yuan - Chieh Yang | 2002 | J NEPHROL2002，15，： | 1 |
| 12 | Preparation and properties of amino - terminated anionic waterborne - polyurethane - silica hybrid materials through a sol - gel process in the absence of an external catalyst 显示文摘 | JUI- MING YEH CH1A - 1\SENG YAO CHI-FA HSIEH | 2008 | European Polymer Journal2008，44，9： | 1 |
| 13 | Technological capability, social capital and the launch strategy for in- novative products 显示文摘 | Ming - Hung Hsieh Kuen - Hung Tsai | 2007 | Industrial Marketing Manage- ment2007，36，4： | 1 |
| 14 | Frequency dependent alter-ationsin regional homogeneity of baseline brain activity in schizophre-nia显示文摘 | Rongjun YU Ming H Hsieh H | 2013 | PLoS One2013，8，71： | 1 |
| 15 | The outcomes of glucose abnormalities in pre‐diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy显示文摘 | Jee‐Fu Huang Ming‐Lung Yu Chung‐Feng Huang Suh‐Hang Hank Juo Chia‐Yen Dai Ming‐Yen Hsieh Nei‐Jen Hou Ming‐Lun Yeh Meng‐Hsuan Hsieh Jeng‐Fu Yang Zu‐Yau Lin Shinn‐Chern Chen Shyi‐Jang Shin Wan‐Long Chuang | 2012 | Liver Int2012，，6： | 1 |
| 16 | Finding Nearest Neighbors in Replication-Aware CDN -P2P Architecture显示文摘 | Min - Yi Hsieh Hung - Chang Yang Li - Ming Tseng | 2005 | Journal of Internet Technology2005，，6： | 1 |
| 17 | On the fairness and com- plexity of generalized k-in-a-row games 显示文摘 | Ming Yu Hsieh Shi-Chun Tsai | 2007 | Theoretical Computer Science2007，，385： | 1 |
| 18 | Effects of Hemerocallis tiara on motor activity and the concentration of central monoamines and its metabolites in rats显示文摘 | Ming tsuen Hsieh Yueh feng Ho Wen huang Peng | 1996 | Journal of Ethnopharmacology1996，52，： | 1 |
| 19 | THE EARLY EFFECT OF PELVIC FLOOR MUSCLE EXERCISE AFTER TRANSURETHRAL PROSTATECTOMY显示文摘 | PHEI LANG CHANG LI HUNY TSAI SHIH TSUNG HUANG TA MIN WANG MING LI HSIEH KE HUNG TSUI | 1998 | The Journal of Urology1998，，2： | 1 |
| 20 | Frequent concomitant epigenetic silencing of SOX 1 and secreted frizzled‐related proteins ( SFRP s) in human hepatocellular carcinoma显示文摘 | Yu‐Lueng Shih Chung‐Bao Hsieh Ming‐De Yan Chun‐Ming Tsao Tsai‐Yuan Hsieh Chang‐Hsin Liu Ya‐Wen Lin | 2013 | J Gastroenterol Hepatol2013，，3： | 1 |
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