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| 1 | Panax notogiseng saponin inhibits ischemia-induced apoptosis by activating PI3K/Akt signal pathway in cardiomyocytes显示文摘The panax notoginseng saponin(PNS) had been clinically used for the treatment of cardiovascular diseases and stroke in China.It had been demonstrated that PNS could protect cardiomyocytes from injury induced by ischemi- a,but the underlying molecular mechanisms of this protective effect were still unclear.This study was aimed to investigate the protective effect and molecular mechanisms of PNS on apoptosis in H9c2 cells in vitro and rat myocardial ischemia injury model in vivo.Annexin-V/PI assay shew that PNS could protect H9c2 cells from apoptosis induced by serum, glucose and oxygen deprivation(SGOD) in a dose-dependent manner.However,the anti-apoptotic effect of PNS was reversed by LY294002,a specific PI3K inhibitor.This antiapoptotic effect of PNS was confirmed by JC-1,a specific probe of mitochondrial membrane potential staining.PNS could significantly increase phos-Akt in H9c2 cells by Western blot assays and its effect could be inhibited by LY294002.Furthermore,PNS could improve ischemic-induced left ventricular function as reflected by EF,LVDd and LVDs.PNS could also inhibited cellular apoptosis in myocardial tissues in ischemic rats by TUNEL assay.PNS administration also increased the expression of phos-Akt in rat ischemic myocardial tissues.These results suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in vitro model and in vivo model through activating-PI3K/Akt signal pathway which may be meaningful for further understanding the molecular mechanisms of cardiac protection of PNS.And the results might be useful in treatment of myocardial ischemia in future. | YANG Min,CHEN Shao-Xian,LIU Ju-Li,LIU Xiao-Ying,FU Yong-Heng,ZHANGMeng-zhen,LIN Qiu-Xiong,ZHU Jie-Ning, SHAN Zhi-Xin,YU Xi-yong (Medical Research Center,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 47 |
| 2 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 3 | Humoral and cellular immunogenecity of DNA vaccine based on hepatitis B core gene in rhesus monkeys显示文摘INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant association among persistentinfection, liver cirrhosis and hepatocellularcarcinoma[1-3]. | Zu Hu Huang1 Hui Zhuang2 Shan Lu3 Ren Hua Guo1 Guo Min Xu2 Jie Cai1 Wan Fu Zhu2 1Department of Infectious Diseases. The First Affiliated Hospital of Nanjing Medical University, Nenjing 210029, Jiangsu Province. China2Faculty of Microbiology, Beijing University, Beijing 100000, China3University of Massachusetts Medical Center | 2001 | World Journal of Gastroenterology2001，7，1： | 19 |
| 4 | Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice显示文摘目的: 到学习, lipopolysaccharide (LPS ) 上的 tanshinone IIA (TIIA ) 的效果在老鼠和内在的机制导致了尖锐的肺损害。 | Min xu Fa-le CAO Yu-fei ZHANG Liang SHAN Xiao-ling JIANG Xiao-jing AN Wei XU Xiu-zhi LIU Xiao-yan WANG | 2015 | Acta Pharmacologica Sinica2015，36，2： | 19 |
| 5 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 6 | A nowcasting model for the prediction of typhoon tracks based on a long short term memory neural network显示文摘It is of vital importance to reduce injuries and economic losses by accurate forecasts of typhoon tracks. A huge amount of typhoon observations have been accumulated by the meteorological department, however, they are yet to be adequately utilized. It is an effective method to employ machine learning to perform forecasts. A long short term memory(LSTM) neural network is trained based on the typhoon observations during 1949–2011 in China's Mainland, combined with big data and data mining technologies, and a forecast model based on machine learning for the prediction of typhoon tracks is developed. The results show that the employed algorithm produces desirable 6–24 h nowcasting of typhoon tracks with an improved precision. | GAO Song ZHAO Peng PAN Bin LI Yaru ZHOU Min XU Jiangling ZHONG Shan SHI Zhenwei | 2018 | Acta Oceanologica Sinica2018，37，5： | 17 |
| 7 | Degradation of chlorpyrifos alone and in combination with chlorothalonil and their effects on soil microbial populations显示文摘在实践,杀虫剂通常为庄稼保护同时或一个接一个被使用,并且这类杀虫剂申请经常在土壤环境导致杀虫剂残余的联合污染。实验室研究被进行在土壤上在 chlorpyrifos 降级和它的效果上调查 chlorothalonil 的影响细菌,真菌,并且放射菌类人口。在这里的试验性的条件下面, chlorpyrifos 的一半生活独自,并且在有 chlorothalonil 的联合,在推荐并且两倍剂量,被测量分别地是 3.24, 2.77,和 2.63 d。Chlorpyrifos 降级没被它的联合显著地与 chlorothalonil 改变。然而,土壤微生物上的 chlorpyrifos 的禁止的效果被它的联合与 chlorothalonil 增加,并且增加与增加的 chlorothalonil 的层次有关。在控制,细菌的人口,真菌,和放射菌类比作那些分别地,被 chlorpyrifos 被 44.1% , 61.1% ,和 72.8% 显著地独自在处理(DAT ) 以后在第一天减少。与 chlorothalonil 的增加,抑制在推荐剂量被增加到 55.2% , 79.3% ,和 85.8% ,并且 86.0% , 94.1% ,和 90.8% 在双剂量在一 DAT,分别地。结果建议联合效果应该被考虑估计杀虫剂应用的实际影响。 | CHU Xiaoqiang FANG Hua PAN Xuedong WANG Xiao SHAN Min FENG Bo YU Yunlong | 2008 | Journal of Environmental Sciences2008，20，4： | 16 |
| 8 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 9 | Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats显示文摘干细胞移植和低精力的冲击波治疗(LESWT ) 为糖尿病的可勃起的机能障碍作为潜在、有效的治疗协议出现了。在在糖尿病的可勃起的机能障碍模型追踪移植干细胞期间,可见干细胞的数字快速相当低、减少。LESWT 能招募内长的干细胞到多孔的身体并且在糖尿病的多孔的织物改进微型环境。因此,我们推断 LESWT 可能有益于移植干细胞幸存并且改进干细胞移植的效果。在这研究, 42 只导致 streptozotocin 的糖尿病的老鼠被使随机化进四个组:糖尿病的组(n = 6 ) , LESWT 组(n = 6 ) ,骨头导出髓的间充质的干细胞(BMSC ) 移植组(n = 15 ) ,并且 LESWT 的联合和 BMSC 移植组织(n = 15 ) 。在 BMSC 移植以后的一和三天,三只老鼠随机被选择在多孔的身体观察 BMSC 的幸存数字。在 BMSC 移植以后的四个星期,下列参数被估计:在多孔的织物,可勃起的功能,即时聚合酶链反应,和阴茎 immunohistochemical 评价的移植 BMSC 的幸存数字。我们发现那 LESWT 的研究在多孔的身体赞成了移植 BMSC 的幸存,它可能与增加的 stromal 有关是导出房间的 factor-1 表示和在糖尿病的多孔的组织的 angiogenesis 的改进。LESWT 和 BMSC 移植的联合能比 LESWT 或 BMSC 移植独自表现的更有效地改进糖尿病的可勃起的功能老鼠的可勃起的功能。 | Hai-Tao Shan Hai-Bo Zhang Wen-Tao Chen Feng-Zhi Chen Tao Wang Jin-Tai Luo Min Yue Ji-Hong Lin An-Yang Wei | 2017 | Asian Journal of Andrology2017，19，1： | 15 |
| 10 | Reactivity of ambient volatile organic compounds(VOCs) in summer of 2004 in Beijing显示文摘周围的不稳定的有机化合物(VOC ) 在 2004 的夏天在北京在六个地点被取样并且由 GCMS 分析了。73 的化学反应性确定了 VOC 种类被评估由哦损失率(LOH ) 和臭氧形成潜力(OFP ) 。顶 15 活性组分,主要链烯和 aromatics,被这二个方法识别,并且占了 VOC 的超过 70% 全部的反应。在城市的区域,异戌二烯是大多数活性组分以哦损失率,贡献 11.4% 到 VOC 的 LOH。当时甲苯,为 9.4% OFP 的财务,看起来在光化过程有一个长期的角色。Tongzhou 地点被本地化学工业显然影响,但是另外的五个地点显示出主要车辆的排出物影响的典型城市的特征。 | Shan Huang Min Shao Sihua Lu Ying Liu | 2008 | Chinese Chemical Letters2008，19，5： | 14 |
| 11 | Sequencing of p53 mutation in established human hepatocellular carcinoma cell line of HHC4 and HHC15 in nude mice显示文摘INTRODUCTIONAlthoughtheetiopathologyofhumanhepatocelularcarcinoma(hHCC)isstilunknown,alotofevidencestronglysuggestedthatinfec... | YANG Shan Min, ZHOU Hong, CHEN Rui Chuan, WANG Yu Fang, CHEN Fu, ZHANG Chang Gong, ZHEN Yun, YAN Jiang Hua and SU Jin Hua | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 12 | Double-balloon enteroscopy in small bowel tumors: A Chinese single-center study显示文摘AIM: To analyze the clinical characteristics of small bowel tumors detected by double-balloon enteroscopy (DBE) and to evaluate the diagnostic value of DBE in tumors. METHODS: Four hundred and forty consecutive DBE examinations were performed in 400 patients (250 males and 150 females, mean age 46.9 ± 16.3 years, range 14-86 years) between January 2007 and April 2012. Of these, 252 patients underwent the antegrade approach, and 188 patients underwent the retrograde approach. All the patients enrolled in our study were suspected of having small bowel diseases with a negative etiological diagnosis following other routine examinations, such as upper and lower gastrointestinal endoscopy and radiography tests. Data on tumors, such as clinical information, endoscopic findings and opera-tion results, were retrospectively collected. RESULTS: Small bowel tumors were diagnosed in 78 patients, of whom 67 were diagnosed using DBE, resulting in a diagnostic yield of 16.8% (67/400); the other 11 patients had negative DBE findings and were diagnosed through surgery or capsule endoscopy. Adenocarcinoma (29.5%, 23/78), gastrointestinal stromal tumor (24.4%, 19/78) and lymphoma (15.4%, 12/78) were the most common tumors. Among the 78 tumors, 60.3% (47/78) were located in the jejunum, and the overall number of malignant tumors was 74.4% (58/78). DBE examinations were frequently performed in patients with obscure gastrointestinal bleeding (47.4%) and abdominal pain (24.4%). The positive detection rate for DBE in the 78 patients with small bowel tumors was 85.9% (67/78), which was higher than that of a computed tomography scan (72.9%, 51/70). Based on the operation results, the accuracy rates of DBE for locating small bowel neoplasms, such as adenocarcinoma, gastrointestinal stromal tumor and lymphoma, were 94.4%, 100% and 100%, respectively. The positive biopsy rates for adenocarcinoma and lymphoma were 71.4% and 60%, respectively. CONCLUSION: DBE is a useful diagnostic tool with high clinical practice value and should be considered the gold standard for the investigation of small bowel tumors. | Wen-Guo Chen Guo-Dong Shan Hong Zhang Lin Li Min Yue Zun Xiang Ying Cheng Chen-Jiao Wu Ying Fang Li-Hua Chen | 2013 | World Journal of Gastroenterology2013，19，23： | 11 |
| 13 | Dissipation of chlorpyrifos in pakchoi-vegetated soil in a greenhouse显示文摘The dissipation of chlorpyrifos in pakchoi-vegetated soil was investig ated in the summer and autumn in a greenhouse and field, respectively. The dissi pation of chlorpyrifos in pakchoi-grown soil was comparatively described by fitt ing the residue data to seven models (1st-order, 1.5th-order, 2nd-order, RF 1st- order, RF 1.5th-order, RF 2nd-order, and bi-exponential or two-compartment model s). Statistical analysis was performed using the SPSS 11.5 statistical package. The bi-exponential model was selected as the optimal model according to the coef ficient of determination r2. The dissipation half-lives (DT50) of chlorpyrifos i n pakchoi-vegetated soil at the recommended dose in the summer and autumn, calcu lated by the bi-exponential model, were 0.6 and 1.2 d in a greenhouse, 0.4 and 1 .0 d in a field, respectively; the corresponding values at double dose were 1.2 and 2.1 d in a greenhouse, 0.5 and 1.3 d in a field, respectively. The kinetic d ata indicate the dissipation of chlorpyrifos in pakchoi-grown soil in a greenhou se is slower than that in a field, and dissipates slower in the autumn than in t he summer. | FANG Hua YU Yun-long WANG Xiao SHAN Min WU Xiao-mao YU Jing-quan | 2006 | Journal of Environmental Sciences2006，18，4： | 9 |
| 14 | An epidemiology study of bronchial asthma in the Li ethnic group in China显示文摘Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge test.Demographic data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were collected.Logistic regression was performed to evaluate risk factors for asthma.Results: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in China.Aging,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of asthma.Conclusions:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population.Risk factors indentified in this study warrant special attention.Elevating public awareness about asthma in local communities will benefit the prevention of the disease. | Yi-Peng Ding Hong-Xia Yao Xiao-Lan Tang Hai-Wu He Hui-Fang Shi Li Lin Min Li Shan Shan Chen Jing Chen Hai-Jiao Wang | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 9 |
| 15 | Dissecting the Genetic Basis of Extremely Large Grain Shape in Rice Cultivar 'JZ1560'显示文摘Rice grain shape,grain length(GL),width(GW),thickness(GT)and length-to-width ratio(LWR),are usually controlled by multiple quantitative trait locus(QTL).To elucidate the genetic basis of extremely large grain shape,QTL analysis was performed using an F2 population derived from a cross between a japonica cultivar 'JZ1560'(extremely large grain)and a contrasting indica cultivar 'FAZ1'(small grain).A total number of 24 QTLs were detected on seven different chromosomes.QTLs for GL,GW,GT and LWR explained 11.6%,95.62%,91.5%and 89.9%of total phenotypic variation,respectively.Many QTLs pleiotropically controlled different grain traits,contributing complex traits correlation.GW2 and qSW5/GW5,which have been cloned previously to control GW,showed similar chromosomal locations with qGW2-I/qGT2-I/qLWR2-2 and qGW5-2/qLWR5-l and should be the right candidate genes.Plants pyramiding GW2 and qSW5/GW5 showed a significant increase in GW compared with those carrying one of the two major QTLs.Furthermore,no significant QTL interaction was observed between GW2 and qSW5/GW5.These results suggested that GW2 and qSW5/GW5 might work in independent pathways to regulate grain traits.'JZ1560' alleles underlying all QTLs contributed an increase in GW and GT and the accumulation of additive effects generates the extremely large grain shape in 'JZ1560'. | Jie-Zheng Ying Ji-Ping Gao Jun-Xiang Shan Mei-Zhen Zhu Min Shi Hong-Xuan Lin | 2012 | Journal of Genetics and Genomics2012，39，7： | 9 |
| 16 | Why high grain yield can be achieved in single seedling machine-transplanted hybrid rice under dense planting conditions?显示文摘This study was conducted to identify the factors associated with high grain yield in single seedling machine-transplanted hybrid rice under dense planting conditions. Field experiments were done in Yong'an Town, Hunan Province, China in 2015 and 2016. Two hybrid rice cultivars were grown under single seedling machine transplanting(SMT) and conventional machine transplanting(CMT) at a high planting density in each year. Grain yield and yield attributes were compared between SMT and CMT. Averaged across cultivars and years, grain yield was 12% higher under SMT than under CMT. Plant height, basal stem width, and shoot and root dry weights were higher in seedlings for SMT than those for CMT. SMT had less maximum tiller number per m^2 and consequently less panicle number per m^2 than did CMT. Branch number per panicle, especially the secondary branch number per panicle, and spikelet number per cm of panicle length were more under SMT than under CMT, which resulted in more spikelet number per panicle under SMT than under CMT. SMT had higher or equal spikelet filling percentage than did CMT. The difference in grain weight between SMT and CMT was relatively small and inconsistent cross years. SMT had higher or equal total biomass and harvest index than did CMT. Dry weight per stem under SMT was heavier than that under CMT. Larger leaf area per stem was partly responsible for the heavier dry weight per stem under SMT than under CMT. Our study suggests that improvement in seedling quality, panicle size, and dry weight per stem are critical to the high grain yield in single seedling machine-transplanted hybrid rice under dense planting conditions. | HUANG Min SHAN Shuang-lü XIE Xiao-bing CAO Fang-bo ZOU Ying-bin | 2018 | Journal of Integrative Agriculture2018，17，6： | 8 |
| 17 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 18 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 19 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 20 | Phosphorylation of Serine 186 of bHLH Transcription Factor SPEECHLESS Promotes Stomatal Development in Arabidopsis显示文摘在 Arabidopsis 的有气孔的系和随后的不对称的部门的开始要求基本 helix-loop-helix 抄写因素的活动哑(SPCH ) 。SPCH 也激活 MITOGEN 的蛋白质 KINASE (MAPK ) 串联或象 GSK3 一样 kinase BRASSINOSTEROID 作为底层控制入口进有气孔的系,这被显示出感觉迟钝 2 (BIN2 ) 。这里,我们证明 SPCH 的三丝氨酸残余看起来是 Cyclin 依赖的 Kinases A 的主要 phosphorylation 目标; 1 (CDKA; 1 ) invitro,并且在他们之中,丝氨酸 186 在有气孔的形成起一个关键作用。怀有在丝氨酸 186 残余上导致 phosphorylation 缺乏的一个变化的 SPCH 构造的表示没能在 spch 0 异种救有气孔的缺点。phosphorylation 模仿异种 SPCH S186D 在怀有主导否定的 CDKA 的指向的表示的转基因的线补充了有气孔的生产缺点; 1 .N146。除了 SPCH 上的调停 MAPK 、调停 BIN2 的 phosphorylation,因此,在丝氨酸 186 点的 phosphorylation 断然在调整有气孔的开发为 SPCH 功能被要求。 | Ke-Zhen Yang Min Jiang Ming Wang Shan Xue Ling-Ling Zhu Hong-Zhe Wang Jun-Jie Zou Eun-Kyoung Lee Fred Sack Jie Le | 2015 | Molecular Plant2015，8，5： | 7 |
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